A penicillin-binding protein inhibitor series to target drug-resistant Neisseria gonorrhoeae Nature Microbiology, Published online: 08 April 2026; doi:10.1038/s41564-026-02309-3Emerging multidrug-resistant Neisseria gonorrhoeae is a global health threat in the treatment of gonorrhoea. This study reports the discovery and characterization of a promising antigonorrhoea agent that addresses antibiotic resistance.

Out Now! A penicillin-binding protein inhibitor series to target drug-resistant Neisseria gonorrhoeae #MicroSky

Impact of intensive control on malaria population genomics under elimination settings in Southeast Asia Nature Microbiology, Published online: 13 April 2026; doi:10.1038/s41564-026-02327-1Intensive control using village malaria posts and mass drug administration reduces parasite effective population size and increases genetic drift, driving founder effects and rapid shifts in resistance allele frequency.

Out Now! Impact of intensive control on malaria population genomics under elimination settings in Southeast Asia #MicroSky

Our Fabulous February issue is out now!

🌊Promoting marine C sequestration
💊Drug targets in Babesia
🦠Giant virus of amoeba
⚕️Autobrewery syndrome
🍄Commensal gut fungi
💉Polio vaccine success

and much more!

#MicroSky

www.nature.com/nmicrobiol/v...

Now published: our work using phylodynamics from surveillance data to quantify and experimentally validate the fitness impact of antibiotic resistance determinants & how this changes with patterns of antibiotic use: www.nature.com/articles/s41...

Parasex generates highly recombinant progeny in Candida albicans with increased virulence - Nature Microbiology An alternative mating system, termed parasex, produces progeny with high levels of genotypic diversity and is able to fulfil the roles of meiosis when it is absent in the fungal pathobiont Candida alb...

OUT NOW! Parasex generates highly recombinant progeny in Candida albicans with increased virulence

By Robert Fillinger, Scott Filler, Anna Selmecki, Richard Bennett,
Matthew Anderson & colleagues.
#microsky @annaselmecki.bsky.social

www.nature.com/articles/s41...

Cartoon illustration showing how Candida auris uses its carbon-sensing pathway to persist on human skin and tolerate Amphotericin B (AMB). Illustration adapted from an image generated by GPT-4.0.

🎄The best Christmas gift ever 🎁 🚀 Out now in @natmicrobiol.nature.com

🔖 I am delighted to share that a major part of my PhD thesis has now been published in Nature Microbiology.

🔍 Check it out: doi.org/10.1038/s415...

Candida auris skin tropism and antifungal resistance are mediated by carbonic anhydrase Nce103 - Nature Microbiology Candida auris can scavenge carbon dioxide from microenvironments through Nce103 to sustain fitness when colonizing human skin.

Out Now! Candida auris skin tropism and antifungal resistance are mediated by carbonic anhydrase Nce103 #CandidaAuris #AntifungalResistance #Microbiology

www.nature.com/articles/s41...

A big thanks to all the authors, reviewers, and readers of Nature Microbiology for their love and support throughout the year.

We are on a break & will be back on Jan 2nd, in what will be a very special year for us!

In the meantime, enjoy a collage made by @francoismayer.bsky.social

#MicroSky 🦠

Congratulations, Kelsey!! Awesome news!

Decreased cytoplasmic crowding via inhibition of ribosome biogenesis can trigger Candida albicans filamentous growth Nature Microbiology - During filamentous growth in the human fungal pathogen Candida albicans, a reduction in ribosome concentration leads to a decrease in macromolecular crowding. Inhibition of...

👉Excited to share our latest work @natmicrobiol.nature.com, revealing a decrease in cytoplasmic crowding during filamentous growth in the human fungal pathogen Candida albicans. Furthermore we found that inhibition of ribosome biogenesis can trigger filamentous growth in this pathogen
rdcu.be/eT1Su

Decreased cytoplasmic crowding via inhibition of ribosome biogenesis can trigger Candida albicans filamentous growth - Nature Microbiology During filamentous growth in the human fungal pathogen Candida albicans, a reduction in ribosome concentration leads to a decrease in macromolecular crowding. Inhibition of ribosome biogenesis can tri...

Out now! Decreased cytoplasmic crowding via inhibition of ribosome biogenesis can trigger Candida albicans filamentous growth

@robertarkowitz.bsky.social

Read it here: rdcu.be/eT3CP

www.nature.com/articles/s41...

Like last year, I compiled a little collage of all our monthly issue covers published in @natmicrobiol.nature.com Another year full of new discoveries, stunning advances and marvelous #microbiology. Thanks to all our authors for all their hard work in pushing the field of microbiology forward.

Our December issue is out!

www.nature.com/nmicrobiol/v...

The image shows a female Asian tiger mosquito cadaver covered by mycelium (white) following infection with spores of an engineered Metarhizium strain. Parts of the mycelium produce spores (green) that can again attract and kill mosquitoes.

Our final issue of 2025 has gone live!

🫁pertussis prevention
🏭pollutants and gut bacteria
🕳️porins and resistance in E. coli
🧬many flavours of CRISPR
🦟fatal fungal attraction

...and more 👇
www.nature.com/nmicrobiol/v...

🚀 New journal alert!
We are Communications AI and Computing: an open access space from @natureportfolio.nature.com for research in AI, ML, and computational science.

Now open for submissions!
www.nature.com/commsaicomp/

#AI #ML #OpenAccess #ComputationalScience #NaturePortfolio #Research

Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus - Nature Microbiology Florfenicol amine hijacks intrinsic resistance in Mycobacterium abscessus, highlighting that antimicrobial resistance mechanisms can be harnessed for antibiotic activation.

Out now in Nature Microbiology 👀

www.nature.com/articles/s41...

Genetic population structure of Haemophilus influenzae at local and global scales - Nature Microbiology Large-scale sequencing and population genomic analyses reveal frequent transmission, a highly admixed global population structure and evidence of pervasive negative selection in Haemophilus influenzae...

Out recently in Nature Microbiology👇

www.nature.com/articles/s41...

Our November issue is out now:

www.nature.com/nmicrobiol/v...

Engineered Metarhizium fungi produce longifolene to attract and kill mosquitoes - Nature Microbiology Insects colonized with Metarhizium fungi emit longifolene to lure new hosts for infection to disperse spores. A fungal strain was engineered to emit longifolene to attract and eliminate mosquitoes.

OUT NOW! - Engineered Metarhizium fungi produce longifolene to attract and kill mosquitoes 🍄🧲🦟☠️

By Dan Tang, Jun Cao, Raymond Leger, Jianhua Huang, Weiguo Fang & colleagues.

www.nature.com/articles/s41...

Isolation, engineering and ecology of temperate phages from the human gut - Nature Human host-associated cellular products may act as induction agents for bacteriophages.

Very excited to share the latest work from our lab, which was published today in Nature!
nature.com/articles/s41...

PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.

Isolation, engineering and ecology of temperate phages from the human gut - Nature Human host-associated cellular products may act as induction agents for bacteriophages.

Isolation, engineering and ecology of temperate phages from the human gut

Out now in Nature, by Sofia Dahlman, Jeremy Barr & colleagues. @jeremyjbarr.bsky.social

#microsky

www.nature.com/articles/s41...

Discovery and artificial intelligence-guided mechanistic elucidation of a narrow-spectrum antibiotic - Nature Microbiology Enterololin is a narrow-spectrum antibiotic that selectively kills Enterobacteriaceae in vitro and in a mouse model of adherent-invasive Escherichia coli gut infection. AI-guided mechanism-of-action s...

Discovery and artificial intelligence-guided mechanistic elucidation of a narrow-spectrum antibiotic

By Denise Catacutan, Jon Stokes & colleagues.

#microsky

www.nature.com/articles/s41...

A generative artificial intelligence approach for the discovery of antimicrobial peptides against multidrug-resistant bacteria - Nature Microbiology This study presents a generative artificial intelligence approach for the high-throughput discovery of antimicrobials against multidrug-resistant bacteria.

A generative artificial intelligence approach for the discovery of antimicrobial peptides against multidrug-resistant bacteria

By Yihui Wang, Guoping Zhao, Lei Zhang & colleagues.

#microsky

www.nature.com/articles/s41...

Toxoplasma gondii VIP1 mediates parasitophorous vacuole–host endoplasmic reticulum interactions to facilitate parasite development - Nature Microbiology Toxoplasma gondii forms membrane contact sites with the endoplasmic reticulum of the host cell to facilitate the transfer of biomolecules to its vacuole.

Toxoplasma gondii VIP1 mediates parasitophorous vacuole–host endoplasmic reticulum interactions to facilitate parasite development

By Julia Romano, Isabelle Coppens & colleagues.

#microsky

www.nature.com/articles/s41...

Our October issue is out now!

The images are negatively stained electron micrographs taken from archaella bundles isolated from the archaeon Sulfolobus acidocaldarius.

Check the issue out here:
www.nature.com/nmicrobiol/v...

Rational design of a hospital-specific phage cocktail to treat Enterobacter cloacae complex infections - Nature Microbiology The Entelli-02 phage product containing five phages has frontline potential to address infections caused by the multidrug-resistant Enterobacter cloacae complex.

OUT NOW: Rational design of a hospital-specific phage cocktail to treat Enterobacter cloacae complex infections

By Dinesh Subedi, Jeremy Barr & colleagues @jeremyjbarr.bsky.social

www.nature.com/articles/s41...

Rational design of a hospital-specific phage cocktail to treat Enterobacter cloacae complex infections - Nature Microbiology The Entelli-02 phage product containing five phages has frontline potential to address infections caused by the multidrug-resistant Enterobacter cloacae complex.

Excited to annouce the latest research published by our lab, which is led by Dinesh Subedi and is out today in Nature Microbiology.

www.nature.com/articles/s41...

Deep-mining the archaeal proteome for antibiotics Nature Microbiology - A deep-learning algorithm unravels a collection of archaeasins, peptides from the archaeal proteome with potential antimicrobial activity and implications for the development...

Deep-mining the archaeal proteome for antibiotics

News & Views by Rafael Laso-Pérez

@gecko1990.bsky.social @delafuentelab.bsky.social

Read it here: rdcu.be/eHNwa

Delighted to review the latest findings on how malaria parasites get into our blood cells and how we might stop it!

September issue out now:

Read it here:
www.nature.com/nmicrobiol/v...