white silk scarf with blood cells

Blood fans check these out #sciart artologica.etsy.com/listing/2091...

Royal College of Pathologists essay prize, open to Vet / Medic undergraduates and Foundation doctors.

www.rcpath.org/discover-pat...

Always like a truism....

Warfarin never causes bleeding unless fired from a cannon.

Expected spleen size | QxMD Provides upper limit of normal for spleen length and volume by ultrasound relative to body height and gender.

Bigger people have bigger spleens.

Proper tear drops those!
🩸

Figure 1. Evaluation of Suspected Polycythemia Vera

Polycythemia vera is a clonal myeloproliferative neoplasm that causes erythrocytosis and is typically associated with a JAK2 gene variant.

This narrative review investigates the diagnosis, symptoms, and management of polycythemia vera.

ja.ma/3PC77Ou

Lots of neutropenia around associated with #flu.
A common complication of viral illness but just seeing it a bit more than usual and a bit more marked than usual.

Holy moley

🩸 How to manage severe #bleeding in patients on oral #anticoagulant? ⤵️

📖 Mithoowani and colleagues provide multidisciplinary expert guidance for managing bleeding during #OAC

🆓 on TH 👉 www.thieme-connect.de/products/ejo...

#HemeSky #MedSky #CardioSky #IMSky

🩸Hematopoietic stem cell differentiation with cytokine regulation #hemesky #hemeonc #medsky #IMsky #internalmedicine #hemepath #pathsky #stemcells

A bit like the NEQAS slides!

#MedTwitter #MedSky #MedEd

RCT (N=199): age 65+ w/ nighttime leg cramps (see 📸 for eligibility)

💊 Vitamin K2 (menaquinone 7) 180 mcg/d vs placebo x 8 wks

🏆 Vit K2 sig decreased frequency of leg cramps!

Also ⬇️ duration/severity. Excellent safety.

buff.ly/4granrk

The answer is in the medical history nearly every time.

Our old Prof used to say we should all keep a slide showing ring sideroblasts by our microscopes at all times

In my eosinophil era #ASH24 #fASHion

Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial There is insufficient evidence to support routine use of tranexamic acid to reduce bleeding in patients with haematological malignancies undergoing intensive chemotherapy.

www.thelancet.com/journals/lan...

Presenting our vision on the future of the @isth-official.bsky.social Guidelines & Guidance committee:

✔️Advancing knowledge translation
✔️Promoting collaboration
✔️Ensuring diversity, equity, and inclusion. #Thrombosis #Hemostasis #Medsky @jthjournal.bsky.social www.jthjournal.org/article/S153...

D-dimer song A song written and performed by the Mashed Potato Man about the perils of requesting a d-dimer in the emergency department I saw a woman in ED and she said she's breathless Her peak flow is low, her chest is full of a wheeze She's clearly asthmatic So why did they ever consider she might have PEs Why, Why, Why D-dimer Why, Why, Why D-dimer Can't you see its low specificity Means you get a false positive and a pointless CT I saw a man with cancer and he said he's breathless He took to his bed then suddenly collapsed to the floor It's clearly an embolus With a false negative d-dimer I had to ignore Why, Why, Why D-dimer Why, Why, Why D-dimer I implore of you see someone breathless just pause Don't send a d-dimer with an obvious alternative cause And remember to work out your pretest probability score.

Evening!

It's much better now but for a while nearly everyone was getting them checked for very non-specific reasons ranging from vague chest pain, sore legs and all sorts.
Then we would get the call... what do we do about the raised D Dimer?

Ever seen the video?
www.google.com/url?sa=t&sou...

Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy - Gafter‐Gvili, A - 2012 | Cochrane Library

Lots of sensible people opt against antibiotic prophylaxis in afebrile neutropaenic patients post chemo/SCT, etc

The Cochrane Review found a strong mortality benefit, so I am interested in the logic

#TxID #IDSky

That sounds too risky for CLL

It is great to see the organisations and journals I closely work with joining BlueSky.
@isth-official.bsky.social
@eahad.bsky.social
@rpth.bsky.social
@jthjournal.bsky.social
If you are involved in thrombosis and hemostasis or hemophilia, consider following them.

ICUS/CCUS/CHIP: basics & beyond - PubMed Patients presenting with idiopathic cytopenia with non-diagnostic marrow morphology and a normal karyotype pose a diagnostic and therapeutic challenge. Additional diagnostic information from mutation ...

🩸 CHIP, CCUS, & ICUS quick definitions:

CHIP
- leukemia-associated gene mutation w/ VAF ≥ 2%
- normal blood counts
- no dx of another hematologic malignancy

CCUS = CHIP with ≥ 1 cytopenias

ICUS
≥ 1 cytopenias + 🚫 identifiable mutation
#hemesky #MedSky #IMsky

A graph showing the exponential recovery of platelets after treatment

Graphs or numbers?

What do you prefer and why.

Female carriers of hemophilia may experience bleeding symptoms. This study reviews discrepancies of FVIII:C levels by one-stage vs. chromogenic assay and their correlation with bleeding phenotype and genetic mutation in females with hemophilia A.

www.jthjournal.org/article/S153...

#MedSky #HemeSky

In the UK, PNH is managed by the very helpful national PNH service. Such a rare disease needs this kind of expertise.

pnhserviceuk.co.uk

Quick #ASH24 quip: pooled OS estimates from initial ibrutinib RCTs suggest survival approaches that of age-matched general population controls, with 9-year OS of 81.2% with ibrutinib and 82% in age-matched population (and 15-year OS 78.4% vs 72% in age-matched population). #lymsm #leusm

One unifying diagnosis?
Eek

This account is following every haematology linked person I can find..

How do I turn it into a starter pack other than manually clicking a whole heap of boxes?

Nice outline!