🎉 lab’s first data paper 🎉

TL;DR: we found profound changes in vocal calls produced by mice with early-onset dystonia caused by cerebellar dysfunction. Thus, vocal impairments in people with dystonia may, in part, be driven by cerebellar dysfunction.

www.frontierspartnerships.org/journals/dys...

Modulating alternative splicing of MECP2 is a potential therapeutic strategy for Rett syndrome Switching of MECP2-e2 to the more efficiently translated e1 isoform up-regulates MeCP2 protein and rescues deficits in RTT iPSC-derived neurons.

New Zoghbi lab MECP2 paper out 🎉: Modulating alternative splicing of MECP2 is a potential therapeutic strategy for Rett syndrome | Science Translational Medicine www.science.org/doi/10.1126/...

Congrats Marissa🤩!!! So incredibly proud of you and your stellar research!!

Guadalupe River flood: How to help and how to find help Several groups have mobilized to offer assistance to people affected by the Guadalupe River floods.

Several groups have mobilized to offer assistance to people affected by the Guadalupe River floods. via @texaspublicradio.bsky.social

Medical Research Funding — Unbreaking How the administration is breaking the government, and what that means for all of us.

I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding.

It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job.

unbreaking.org/issues/medic...

Cutting the NIH—The $8 Trillion Health Care Catastrophe This JAMA Forum discusses the recent budget cuts to National Institutes of Health (NIH), the effects of these cuts on scientific research and health of individuals in the US, and the prospects for cha...

Two Harvard economists forecast the impact of the administration’s proposed NIH budget cuts- stunning losses in new therapies, life expectancy, and economic output with a “social cost 16 times greater than the savings the administration is attempting to achieve."

jamanetwork.com/journals/jam...

Thank you Julian!! So great to hear from you!

Thanks Rebecca 😊!!

Text reads "Congratulations to the 2025 Leading Edge Fellows" followed by the Leading Edge logo and www.leadingedgesymposium.org. Below are the headshots and names of the 40 new Leading Edge Fellows. They are Cel Welch Lianna Wat Maria Toro Moreno Sarah Talley Xulu Sun Ines Sturmlechner Virginia Savy Amelie Raz Kali Pruss Caterina Profaci Sarah Pierce Melissa Pamula Kehinde Odufowora Patricia Nano Ariana Musa de Aquino Nour El Houda Mimouni Kathleen Martin Brea Manuel Mable Lam Miri Krupkin Elaine Kouame Megan Kirchgessner Sumin Kim Shubhangini Kataruka Geraldine Jowett Andrea Jones Leanne Iannucci Emily Heckman Allison Girasole Florencia Fernandez Chiappe Tonie Farris Hannah Elam Erin Doherty Xiaoyun Ding Maria Bustillo Julia Brunner Debadrita Bhattacharya Lorena Benedetti Ashley Anderson Krisha Aghi

We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines.

Learn more about these exceptional scientists:

www.leadingedgesymposium.org/fellows

Evolution of the cellular landscape in mammalian striatum The dorsal striatum is important for highly specialized functions including movement, learning, and habit formation. However, it is not known if species-specialized behaviors are associated with cellu...

We are super excited to share our latest pre-print in collaboration with @sonjavernes.bsky.social lab! www.biorxiv.org/content/10.1... : Evolution of the cellular landscape in mammalian striatum 🧠🧬🧵