#eNeuro | Parvalbumin Neuron–Targeted Loss of Alzheimer’s Disease Risk Gene BIN1 Is Insufficient to Drive Cognitive or Network Excitability Changes
https://doi.org/10.1523/ENEURO.0304-25.2026

Parvalbumin Neuron–Targeted Loss of Alzheimer’s Disease Risk Gene BIN1 Is Insufficient to Drive Cognitive or Network Excitability Changes Bridging integrator 1 ( BIN1 ) is one of the strongest genetic risk factors for Alzheimer’s disease (AD), yet its function in the brain and role in AD remain unclear. Neuronal BIN1 isoform levels are ...

PV or not PV? That was the question.

BIN1 is a leading AD risk factor and critical in inhibitory neurons. However, BIN1 loss from PV INs is not enough to disrupt the system.

Check out some of my graduate work recently published in #eNeuro @sfnjournals.bsky.social
www.eneuro.org/content/13/3...

Great work sharing methods for successful science communication by an awesome group at @uabneuro.bsky.social | featured in #JNeurosci @sfnjournals.bsky.social

www.jneurosci.org/content/46/1...