The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects - Molecular Psychiatry Molecular Psychiatry - The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects

50 years ago, Alexander Shulgin showed that 4-alkylated 2,5-dimethoxyamphetamines peak in potency with 2–3 carbon chains. We suggest longer chains reduce psychedelic-like effects mainly due to poor brain penetration, not reduced receptor activity. doi.org/10.1038/s413...

#psychedelics

Acute Effects and Pharmacokinetics of LSD after Paroxetine or Placebo Pre‐Administration in a Randomized, Double‐Blind, Cross‐Over Phase I Trial Psychedelics, such as psilocybin and lysergic acid diethylamide (LSD), are being investigated for the treatment of depressive and anxiety disorders, for which concomitant treatment with selective ser...

A recent study suggests that no dose adjustment of #LSD is necessary in the presence of an SSRI that inhibits CYP2D6. #psychedelics ascpt.onlinelibrary.wiley.com/doi/10.1002/...

Thanks :)

Dino Luethi ‪University Hospital Basel‬ - ‪‪Cited by 1,530‬‬ - ‪Neuropharmacology‬

Hi Monica, I would love to be added. I’m doing research in the field pf neuropharmacology & clinical pharmacology: scholar.google.com/citations?us...

Acute dose-dependent effects and self-guided titration of continuous N,N-dimethyltryptamine infusions in a double-blind placebo-controlled study in healthy participants - Neuropsychopharmacology Neuropsychopharmacology - Acute dose-dependent effects and self-guided titration of continuous N,N-dimethyltryptamine infusions in a double-blind placebo-controlled study in healthy participants

Acute dose-dependent effects and self-guided titration of continuous #DMT infusions. www.nature.com/articles/s41...

Nice to meet you all here!

1) I began with characterizing designer drugs and later transitioned to bioanalysis of psychedelics

2) I'm mostly setting up methods for the bioanalysis of upcoming phase I studies

3) Arrested Development is my favorite TV show—I should watch it once again soon

Here is a starter pack I put together featuring all the psychedelic science researchers and journalists I could find on here. Let me know who I'm missing. It'd be great to get the conversation going on this platform go.bsky.app/NPvFX41

Thrilled to share the final product for an excellent collaboration with A. Sherwood & co at Usona Institute 😎.

Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below:

pubs.acs.org/doi/10.1021/...

It contains images of a few pages of Hofmann’s lab book and some other things related to the LSD discovery. However, it is not a reproduction of the entier lab book.

Very nice early Christmas gift from our research group. Some insights into Albert Hofmann's work at Sandoz from the Novartis archives. A very nice read while waiting for the mass spec to measure our latest LSD plasma samples. #psychedelics #neuroskyence