Intestinal low-dose RT promotes the enrichment of beneficial bacteria in the gut and increases circulating cholesterol, α-tocopherol and distinct bile salts, thus mobilizing DCs towards mesenteric LN and tumour-draining nodes, culminating in tumour
infiltration by activated effector CD8+ T cells.
A very interesting and enjoyable article to read on @NatRevClinOncol (doi.org/10.1038/s41571…) which takes stock of the complex mechanisms of interaction between the microbiota and radiotherapy #radonc.
Maybe we could reduce volumes in radiotherapy as well. Post neo-adjuvant chemo volumes are based on what is seen at time 0. In light of this, the paradigm could change. Maybe it's time to shift towards involved volumes also in H&N. #radonc
"MDs embody the archetype of the "just" who does not dwell in the ivory tower, standing from afar as an unattainable model, but who is immersed in the contradictions of the world also making mistakes, however contributing actively, creature among creatures, to give solidity and future to humans"
An editorial in #IJROBP that gives much food for thought. It attempts to answer the question of questions : whats is the sweet spot of true synergy between local and systemic treatment to optimize the intensity of local or systemic therapy depending on the clinical situation ? #radonc
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Non ci salverà nemmeno il blocco della Legge sull'Autonomia differenziata. Servirebbero investimenti intelligenti in personale ( fattore più importante) ed in tecnologie. Così facendo si attutirebbe il vero virus dentro il sistema: la migrazione sanitaria. A quel punto saremmo davvero autonomi.🇮🇹
“La macchina che non è solo più esecutrice ma in qualche modo «partner cognitivo» dell’uomo è l’autrice della rivoluzione dei nostri giorni.” @pbenanti.bsky.social
Thanks for creating a #radonc community on @bsky.app .
"L’artefatto oggi si fa dispositivo informatico, si fa machina sapiens – almeno nelle versioni più avanzate che oggi mostrano smartphone e computer – cioè dispositivo che imita parti di quelle capacità uniche che ci fanno umani".
