Congratulations @belindaparker.bsky.social and collaborators on the new @natrevcancer.nature.com release! 🤩

They summarize the regulation and function of type I IFNs in cancer, with a focus on tumor-intrinsic mechanisms controlling canonical and chronic signaling.

🔗 https://go.nature.com/3PqzXVh

Our immune system has a powerful role fighting cancer — but it’s all about balance.

New research led by @belindaparker.bsky.social's lab at Peter Mac shows interferons can boost treatment when just right, but too little or too much can help cancer evade or resist treatment.
More: lnkd.in/gvYQhqJF

Striking the right balance with type I interferon signalling in cancer - Nature Reviews Cancer Type I interferons (IFNs) critically influence cancer development, progression and therapeutic response. In this Review, Parker, Haynes and colleagues explore the complexity of IFN signalling, with a ...

Review @natrevcancer.nature.com @petermaccc.bsky.social
Striking the right balance with type I interferon signalling in cancer
www.nature.com/articles/s41...

Hope you enjoy and please share around if you did, free link to access is here -> rdcu.be/e9zVt Thank you to everyone who helped get this over the line! 🧬📷👨‍🔬

@petermaccc.bsky.social @unimelb.edu.au

We covered a range of topics including therapeutic modulation of IFNs, genomic and epigenetic regulation, influences of age and hormones and functional consequence of both the loss and chronic activation of this pathway in cancer.

This review article was a huge effort over the last 18 months from a team of myself, Joan So, Paul Hertzog, Nicole Haynes and Belinda Parker and I'm extremely grateful to the editors of Nature Reviews Cancer for helping us through many many revisions and edits before the final piece was written.

Very pleased to announce we have published a new review in @natureportfolio.nature.com this morning titled "Striking the right balance with type I interferon signalling in cancer"

-> t.co/q2XHWYFyLL

Peter Mac has been named Australia's leading #cancer research institute in The Australian newspaper's Research 2025 Magazine, and four of our researchers were named as leader in their field.

Read more: www.petermac.org/about-us/new...

The hallmarks of cancer immune evasion Cancer cells often evade the host immune system, challenging the effectiveness of immunotherapy. In this comprehensive review, Galassi et al. summarize key mechanisms of immune evasion within the “thr...

The hallmarks of cancer immune evasion
www.cell.com/cancer-cell/...

The complexity of immune evasion mechanisms throughout the metastatic cascade - Nature Immunology This Review on the interplay between the immune system and metastasis is part of our wider Series of Reviews on Cancer Immunology and Immunotherapy.

Just sharing to my new BlueSky followers the review we published a couple of months ago. I think it summarises the topics we look at in our lab well and highlights the complexity of immune evasion in the metastatic cascade
🦴🧠🫁🧬

➡️ www.nature.com/articles/s41...

Peter Mac is excited to join BlueSky! 🦋 We look forward to sharing ideas, fostering positivity, and connecting with you all as we work together to advance cancer care and research. Let’s inspire, collaborate, and make a difference!

For ECRs going to Lorne Cancer 2025 - Rego & abstract submission is now open for the 2025 OzMRS ECR Symposium on Feb 12 - Join us for a day of extraordinary metastasis research!
Talks, flash talks and poster presentations are available. Abstract deadline is Dec 6. www.ozmrs.com/2025-ecr-sym...