Huge congratulations to Ed and co on this! Once you are a part of the HD research community you never really leave and this news is just so amazing 🥲

I’ll always be an acdc hater #aushottest100

Blasting the Triple J Hottest 100 Australian songs for my Danish neighbours at 10am so they can learn more about their queens culture 😌 #aushottest100

Welcome to Trump Tracker: Probationary workers at health agencies being fired today Follow President Donald Trump’s impact on U.S. research and science globally

Major U.S. health agencies, including the NIH and the CDC, are firing thousands of probationary employees this afternoon.

Follow Science’s coverage of President Donald Trump’s impact on U.S. research and science globally. ⬇️ scim.ag/40XtSSi

Truly a Berlin snowman

I think my main marketable skill is being able to tell whether Trent Reznor made the soundtrack without having to look it up

Smarter Copenhagen commuters chose to wfh today

A nice write up on the paper and our findings in Chemistry World, thank you @gomobel.bsky.social!

Protein Chirality and the Origin of Life | Carlsbergfondet.dk

So excited that the work on protein chirality and the origins of life on this planet will continue with this grant awarded to @bbkrage.bsky.social - huge news! Stort tillykke!!! www.carlsbergfondet.dk/det-har-vi-s...

Thanks for the write up Derek!

Yes that is very cool! I think that nucleotide chirality might be one of the natural pressures leading to our world with predominantly L-proteins. Fun to speculate, hard to test 😅

No just with the peptides. I think quite hard (or expensive!) to obtain a full protein in D-amino acids, but it would be sooooo cool to do and really a dream experiment especially if it could be 15N labelled too!

Thanks Kresten!

I’ve been so thrilled and honoured to be a part of this work alongside Amanda and @bbkrage.bsky.social as well as all of the other authors. And so thankful for funding of course from MSC Actions 🇪🇺

It seems there is a grey zone in which interactions with some disorder can still occur regardless of chirality. What does this mean for biochemical ancient history? Why did we end up in a world that is strictly made up of left handed proteins when these interactions can occur???

Turns out, chirality doesn’t matter at all in a completely disordered interaction. What about interactions that are a little bit disordered? Even so, a weaker interaction still occurs. This shocked us because it seems common sense that ANY structure would preclude interaction

Stereochemistry in the disorder–order continuum of protein interactions - Nature Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.

We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered???

www.nature.com/articles/s41...

More followers on here in the last week than the last 6 months, I wonder what could have changed 😅😬

A labor of love - our review on why IDRs matter for cellular function is live in Nat. Rev. Mol. Cell. Biol:
www.nature.com/articles/s41...

Working with Birthe Kraglund on this was such a pleasure, and we hope this review will be helpful to a broad audience!

Feeling vulnerable (writing a research proposal)

@danirabaiotti.bsky.social hello could i be added to the feed 🧪 biochem/neuroscience person over here 🧠

i research neurodegenerative proteins (& other idps!) & how their interactions lead to pathology. have bounced between huntington's, alzheimer's & parkinson's, & from structural biology to mouse models & human tissues, so v much a jack-of-all-trades when it comes to neurodegenerative diseases

migrating to a new platform feels harder than moving internationally in my 30s honestly