Electroencephalography, pupillometry, and behavioral evidence for locus coeruleus-noradrenaline system related tonic hyperactivity in older adults Neuroimaging studies have shown that age-related dysregulation of the locus coeruleus-noradrenaline (LC-NA) system is associated with cognitive declin…

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Evidence of locus coeruleus-noradrenaline (LC-NA) hyperactivity in older adults using behavioral, pupil and EEG data

@maramather.bsky.social

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Excess iron may accelerate amyloid beta accumulation in the brains of older mice Aging is a natural physiological process that may be accompanied by pathological changes, particularly in the brain. Iron is an essential trace elemen…

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Iron overload in the aging mouse brain was linked to higher amyloid beta (Aβ) plaque aggregation and worse working memory

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Articles cover white matter hyperintensities in relation to cognitive reserve and amyloid burden, light sensitivity in AD, oligodendrogenesis in the aging brain, and more.

www.sciencedirect.com/journal/neur...

Regional growth rates of white matter hyperintensities are associated with beta-amyloid burden There is increasing evidence for an association between white matter hyperintensities (WMH) and brain beta-amyloid deposition. How WMH are longitudina…

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Longitudinal growth rate of white matter hyperintensities (WMH) increases with baseline beta-amyloid burden, but decreased with anti-hypertensive medications

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White matter hyperintensity regression: Fact or artifact? White matter hyperintensities (WMH) are an MRI-based biomarker associated with aging, Alzheimer’s disease, and vascular dementia. Although the volume …

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Whereas the volume of white matter hyperintensities (WMH) typically increases with age and disease, WMH volume can also decrease

@wilcocklab.bsky.social

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New paper! Out now in Neuropsychologia: “Sparsity and memory constraints interact with training sequence to bias learning of associative maps” with @dalezhou.bsky.social*, @kwcooper.bsky.social, @lovecrabmeat.bsky.social, and @aaronbornstein.bsky.social. authors.elsevier.com/a/1mipv6TBG9...
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Time-restricted feeding rescues sociability deficits and reduces neuroinflammation in aged mice The aging brain exhibits an increased inflammatory potential which in turn elicits behavioral changes e.g., social withdrawal. Social isolation is a r…

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Time-restricted feeding in mice reduced age-related hippocampal inflammation and social withdrawal, but had no effect on weight

@louise-ince.bsky.social @fonken.bsky.social

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From cradle to cortex: An exposome‐ and equity‐centered perspective of neurocognitive aging and dementia risk in the era of climate change The convergence of climate change, adverse environmental exposures, and rapid population aging necessitates an equity-based paradigm shift in safeguarding brain health across the life course. Older .....

In this new piece that I had the privilege of working on with Kelly Perry, we discuss the implications of the rising population of older adults alongside increasing intensity of environmental exposures. doi.org/10.1002/alz....

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Articles cover effects of time-restricted eating on inflammation, locus coeruleus hyperactivity, and iron-related amyloid accumulation in aging, and more.

www.sciencedirect.com/journal/neur...

Childhood maltreatment alters associations between age and neurocognitive health metrics in community-dwelling adults To further understand whether childhood maltreatment (CM) is associated with indicators of accelerated cognitive aging, this study investigated whethe…

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Childhood maltreatment modulates (increases and decreases) the effect of age on gray matter volume and moderates the association between age and executive function

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Depressive symptoms and plasma AT(N) biomarkers among cognitively healthy and mild cognitively impaired in a diverse cohort Depression is a known risk factor for dementia and MCI, but its associations with AT(N) biomarkers remain inconsistent and may differ by cognitive sta…

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High depressive symptoms in a diverse cohort of healthy control and MCI participants were linked to higher plasma NfL and p-tau181 levels, but not Aβ42/40

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1H-MR spectroscopy biomarkers are associated with plasma-derived biomarkers of amyloid-β and tau in the early phase of AD continuum The objective of the study was to evaluate the relationship of plasma biomarkers of Alzheimer’s disease (AD) with in vivo proton magnetic resonance sp…

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Lower tNAA/mIns in hipocampus and posterior cingulate was associated with higher p-tau181/Aβ42 and p-tau181 and lower Aβ42/40

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Logo: Center for Vital Longevity Meet the Expert, Dr. Mustapha Bouhrara, National Institute of Aging

Next Monday, Dr. Mustapha Bouhrara will join us for a #ScienceLuncheon on Progress in Understanding Aging and Dementia: MRI Physics, Biomarkers, and White Matter Health.

Event Details: tinyurl.com/5n6cbrvj

🍽️ RSVP required for in-person attendance only!

#CVL #UTDallas

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Articles cover optimized atlases for tau-PET staging, depressive symptoms and MR spectroscopy biomarkers of early AD, and more.

www.sciencedirect.com/journal/neur...

Optimized atlas for early tau-PET staging via native space segmentations Positron Emission Tomography (PET) early Braak staging might be susceptible to anatomical variability and atrophy in the medial temporal lobe (MTL) st…

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Atlases for tau-PET staging can be optimized by segmenting in native space and smoothing at 6mm

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Identifying a proteomics signature of cognitive impairment and dementia in blood and cerebrospinal fluid through a mediation analysis framework This study aimed to identify CSF and plasma proteins that mediate the association between age and mild cognitive impairment (MCI) and Alzheimer’s dise…

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Across 3 datasets (3000+ participants), GFAP in both CSF and plasma consistently mediated the effect of age on cognitive impairment and dementia (MCI/AD incidence)

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Targeting neuronal activity and neuroinflammation for the treatment of Alzheimer’s disease in a mouse model Alzheimer’s disease (AD) is characterized by progressive cognitive decline driven by complex pathological processes, including tau hyperphosphorylatio…

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Treatments targeting inflammation (DHCA) and neuronal activity (Mal-gluc) significantly improved recognition memory in 3xTg-AD mice, but did not reduce p-Tau or Aβ burden

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Hippocampal 1H-MR spectroscopy metabolites are linked to CSF tau pathology in cognitively unimpaired older adults along the Alzheimer’s continuum Relationships between Alzheimer’s disease (AD) pathologies in cognitively unimpaired adults and in vivo neurometabolic properties measured directly fr…

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Tau relates to MR spectroscopy estimates of N-acetylaspartate and myo-inositol in cognitively-unimpaired amyloid-positive adults

@elizabethhead.bsky.social

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Most Alzheimer’s cases linked to variants in a single gene Potentially more than 90% of Alzheimer’s disease cases would not occur without the contribution of a single gene (APOE), according to a new analysis led by UCL researchers.

Most Alzheimer’s cases linked to variants in a single gene ucl.ac.uk/news/2026/ja... by @ucl.ac.uk

#Alzheimers #dementia #science #neuroscience #NeuroSkyence

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Articles cover age-related structural differences in the fischer brown Norway rat and bonnet macaques, apraxis deficis in Alzheimer's Disease, proteomic markers of aging, and more.

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Microstructural changes in locus coeruleus-cortical projections in aged bonnet macaques are independent of myelin loss The locus coeruleus (LC) is a brainstem nucleus best known for being the primary site of noradrenaline production for the forebrain and is involved in…

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MRI-based diffusion metrics are higher in aged macaques in the central tegmental tract, an ascending projection from the locus coeruleus

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Cerebral small-vessel disease severity, hypertension, and body mass index forecast striatal dopamine D2-receptor decline rates in aging Normal aging is associated with decline in dopamine function. Factors associated with individual differences in dopamine decline rates remain unclear …

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Markers of cerebral small-vessel disease (white-matter lesions, lacunes) and vascular risk (e.g., hypertension, BMI) relate to faster 5-year decline in striatal dopamine (DRD2)

@lipmpib.bsky.social

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High estimated pulse-wave velocity is associated with lower brain white matter microstructural integrity twelve years later High pulse wave velocity (PWV), a measure of increased arterial stiffness, is a risk factor for cerebrovascular disease. PWV can be estimated (ePWV) f…

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Higher pulse wave velocity is associated with white matter microstructural damage in older adults 12 years later

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Repeated brain MRI utility in identifying neurodegenerative disorders at the pre-dementia stage Despite the increasing availability of biomarkers in clinical settings, diagnosing individuals with subtle cognitive/behavioral symptoms and normal st…

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Repeated MRI measures of brain volume can help detect later conversion to AD/FTD

www.sciencedirect.com/science/article/pii/S0197458025001265

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Articles cover pulse-wave velocity, cerebral small vessel disease, choroid plexus volume, hearing loss, and racial discrimination in aging, and more.

www.sciencedirect.com/journal/neurobiology-of-aging/vol/156/suppl/C

Integrating plasma, MRI, and cognitive biomarkers for personalized prediction of decline across cognitive domains Plasma biomarkers are associated with cognitive performance and decline in Alzheimer’s disease, making them promising for early detection. This study …

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MRI-derived regional volume and thickness are stronger predictors of cognitive decline, especially for memory, but plasma biomarkers do add predictive value

www.sciencedirect.com/science/article/pii/S0197458025001137

White matter hyperintensities contribute to early cortical thinning in addition to tau in aging White matter hyperintensities (WMH) are associated with cortical thinning in distant brain regions. However, it is currently unclear how WMH affect ne…

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WMH in the temporal lobe relate to early cortical thinning in AD, beyond what is expected due to amyloid and tau

@leoriki3.bsky.social @compneurology.bsky.social

www.sciencedirect.com/science/article/pii/S0197458025001216

Blood oxygenation level-dependent responses in neuromodulatory nuclei and their associations with attention and memory across age groups Using multi-echo blood oxygenation level-dependent (BOLD) neuroimaging, we examined lifespan differences in three subcortical nuclei important to the …

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BOLD in LC related to subsequent memory performance in adults across the lifespan, possibly due to attentional boosting of memory

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Comparison of CSF neurofilament light chain and total tau as neurodegeneration markers: Associations with synaptic markers and cognitive outcomes Clinically, Alzheimer's disease (AD) is characterized by progressive cognitive decline due to neuronal and synaptic degeneration. Neurofilament light …

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T-tau, a marker or gray matter degeneration, is more strongly correlated with synaptic biomarkers (neurogranin and BACE1) than NfL

www.sciencedirect.com/science/article/pii/S0197458025001198

New paper in Imaging Neuroscience by Adam Kimbler & Craig E.L. Stark:

Advanced diffusion imaging in grey matter reflects individual differences in cognitive ability in older adults

doi.org/10.1162/IMAG...