Psychedelic 5-MeO-DMT induces dissociated state in mice A new study published in Communications Biology shows how an injection of the psychedelic compound 5-MeO-DMT induces a dissociated brain state in mice, combining elements of sleep and wakefulness.

A new "behind the paper" blogpost from @benbreant.bsky.social at @psl-univ.bsky.social on their recent publication dealing with the effects of the psychedelic 5-methoxy-N,N-dimethyltryptamine on mice brain:
communities.springernature.com/posts/psyche...

Vigilance state dissociation induced by 5-MeO-DMT in mice - Communications Biology Administration of 5-MeO-DMT produces a dissociated brain state in mice, characterized by global slow-wave activity alongside behavioral wakefulness and marked pupil dilation.

Our paper with @vyazovskiy.bsky.social showcasing research conducted at @ox.ac.uk @oxforddpag.bsky.social is out!

We describe the effects of the psychedelic 5-MeO-DMT on brain states and sleep via EEG, LFP & freely moving oculometry.
Read more: www.nature.com/articles/s42...

#EEG #neuroskyence

I passed my DPhil viva yesterday 🎉 A huge thanks to my examiner, Stuart Peirson and Matt Jones who've done an exceptional job, and a bigger thanks to my Dphil supervisors Vlad Vyazovskiy, David Bannerman and Trevor Sharp!

Sleep-like state during wakefulness induced by psychedelic 5-MeO-DMT in mice Psychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms rather than corresponding to an altered brain state or a distinc...

"Paradoxical wake" archive paper update, with new content & new prospects 🧪🧠
We show global slow waves after psychedelic administration + eye monitoring of freely-moving mice! A thrilling project with @vyazovskiy.bsky.social & @oxforddpag.bsky.social
#EEG #sleep

www.biorxiv.org/content/10.1...

The Paris Brain Institute has its start pack!
go.bsky.app/Km2Qe2D

Courtesy of @nikolaskaralis.bsky.social !
If you are from ICM and want to join, let him know!

If you don't know ICM, you can find more info here:
parisbraininstitute.org

Hey Nikolas! Can you add me as well? Thanks! 😄

How animals learned to hibernate and why we can’t do it (yet) | Aeon Essays Hibernation allows many animals to time-travel from difficult times to plenty. Could humans learn how to do it too?

An excellent read on hibernation from Vlad Vyazovskiy, and thoughts provoking as per usual!
aeon.co/essays/how-a...

Science & Academic peeps: You work with psychedelic? You know someone who work on psychedelics? Come my way! Let's expand our footprint on this network 🍄🧠🧪

We (S Sarasso, A Tzovara & K Peller) guest-edited a special issue for the Eur J of Neuroscience

Measures & Mechanisms of Consciousness
onlinelibrary.wiley.com/doi/toc/10.1...
🧠🧪💤

12 articles on sleep, dreams, mind blanking, disorders of consciousness & more!

With a great cover from Nicolas Decat

Hey Tony, great thing!
I'd love to join if you'll have me 🙂

“Paradoxical wakefulness” induced by psychedelic 5-methoxy-N,N-dimethyltryptamine in mice Vigilance states – waking, slow-wave sleep (SWS) and paradoxical sleep, are thought to be controlled by several cortical and subcortical neuromodulatory circuits, among which the serotonergic (5-HT) s...

Before working on dreams and human, I was studying psychedelic & sleep in rodents!
In this preprint from my DPhil thesis, we show the occurence of an altered state with features of both sleep and wake in mice injected with 5-MeO-DMT. Stay tune, there is more to come!

www.biorxiv.org/content/10.1...