Interested in #Mechanobiology? Join us for the Mechanobiology Symposium, hosted by the new Cornell Mechanobiology Hub @weillinstitute.bsky.social in Ithaca, NY, this summer. More information at mechanobiology.wicmb.cornell.edu/events-progr...
Deadline for abstract submission is April 15, 2026
Ready for Halloween 👻
Postdoc position available!!! We are looking for a creative postdoc to develop independent research directions in tissue morphogenesis using embryos, stem cell/organoid systems, and quantitative imaging and/or biophysics. Here are the details: livejohnshopkins-my.sharepoint.com/:b:/g/person...
Tenure-track faculty position at all levels in Data Science and Artificial Intelligence for Mechanical Engineering at Hopkins. APPLY :) apply.interfolio.com/175773
Last chance to tell the NIH if you think animal models are important for biomedical research! 👇👇👇👇
Excited to grow our team! The Tissue Morpho and Mechanics Lab at Hopkins is seeking a full-time Lab Technologist (50% lab tech + 20% lab manager + 30% scientist) to support our research in developmental biology and biomechanics 🐸🖖🔬🧪🫵. Great opportunity to be part of a vibrant and curious group.
What a fantastic essay by last year's @mblscience.bsky.social Embryology students! A perfect paean to the most wonderful science: "It's exhausting; it's exhilarating; it's Embryology."
journals.biologists.com/dev/article/...
Hi everyone! I'm offering a new course, Introduction to Mechanobiology, for upper-level undergraduates and new graduate students in engineering. I'm seeking a textbook and resources for teaching. If you've taught a similar course or have recommendations, I'd love to hear your suggestions. Thank you!
MSK's Dr. Alexandra Joyner is hanging up her lab coat following an illustrious 40-plus-year career. When asked what advice she has for new scientists, she shares: "You have to decide: Why are you going into this career? And then you have to stay true to that." Learn more about her legacy & impact ⬇️
Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...
Interaction between two cells is necessary and sufficient to initiate PCP sorting😀, as shown by Lena P. Basta, Bradley W. Joyce, Dr. Eszter Posfai @eposfai.bsky.social , and Dr. Danelle Devenport. Here is the article. www.science.org/doi/10.1126/...
R.I.P.... Dr. Michael Sheetz was a pioneer in mechanobiology. The review paper by Dr. Viola Vogel and Dr. Sheetz, published in 2006, was one of the first review articles I read when I started my Ph.D.
Are they bicoid and caudal? How did the 17th Century Tibet get this????AMAZING!
X. Mess Party fires on to celebrate the end of the first semester! Thank you all for your commitments to do the hard work!!!
Applications open for a new cohort of @dev-journal.bsky.social *Pathway to Independence* fellows
Know a #devbio post-doc about to enter the academic job market?
Would they benefit from a little support & mentoring?
Spread the word
Deadline 31 Jan 2025
journals.biologists.com/dev/pages/pi...
Our IOS Virtual Office Hour this month is on what to do post-review with your individual reviews, panel summary & Program Officer comments. December 19th from 1-2pm ET. We'll share valuable info for anyone about the merit review process. See you there!
iosblog.nsfbio.com/2024/12/04/d...
😅Please add me to both "morphogenesis" and "collective cell migration". Thank you, Maik!
If you're searching for the Mechanobiology community and starter pack, here it is:
Thought this would be a great opportunity to gather the #mechanobiology community. Please feel free to spread the word.
go.bsky.app/G5cQqYT
Even though there are great #devbio and #biophysics starter packs, I felt #morphogenesis & #organogenesis was missing as a subfield :D
Far from complete or full. Tell me if you want to be added!
go.bsky.app/PB6s8PQ
Hi Maik, Thanks very much for creating the starter packs. Could you please add me?
Hopkins faculty: Need editorial assistance for a proposal or an article? Make use of our services at no charge.
Contact my office here: research.jhu.edu/rdt/easi/
Happy writing!
Follow and spread the word please🐸🪰🐟🐭🪱🦋🐙🏄♀️🔬🌱🦠🥣🐣
Last but not least, huge thanks to all co-authors, Dr. Yasuhiro Inoue, Masaya Hayashi, and Dr. John Wallingford @jbwallingford.bsky.social . Special thanks to the editor, Dr. Deborah Taylor, for her guidance, and the reviewers for their invaluable feedback.
Figure 6: When scaling up to tissues, CE spreading and propagation are essential. In Arvcf-deficient tissue, disrupted t-junction rotation is correlated to localized and discontinuous convergence, showcasing an impaired multiscale mechanical synergy at play.
Figure 5: Using a dynamic vertex model, we found that a single t-junction rotation can trigger cascading cell intercalations, spreading CE across the tissues. A biomechanical domino effect!
Figure 4: Our static toy models reveal how perpendicular t-junctions block force coupling and propagation, demonstrating how microscale defects escalate to large-scale abnormalities.
Figure 3: Our previous work on Arvcf revealed its role in maintaining cell cortex tension. Interestingly, Arvcf depletion delays t-junction rotation, leading to many more perpendicular t-junctions. This subtle change in cell packing is indeed akin to a “traffic jam”.
Figure 2: T-junction rotation is driven by a “four-way tug-of-war” between tensions on connected v-junctions. We employed a non-invasive image-based analysis to confirm this tension-based mechanism. Please stay tuned for more details on this method.
Figure 1: Here we focused on the overlooked resolution phase of cell intercalation—highlighting t-junction extension and rotation, described in vertebrates for the first time.
Key takeaway: Our study shows how force-dependent vertex resolution affects cell packing and polarized force propagation, facilitating the propagation of CE. This bridges the gap between cellular mechanics and tissue shaping. Let’s walk through the key findings! 👇
