Neuron (@cp-neuron) Bsky

Dentate gyrus interneurons modulate winner-take-all network dynamics in freely behaving mice Hainmueller, Heynold, et al. studied the activity and synaptic interactions of different excitatory and inhibitory neuron types in the dentate gyrus of freely behaving mice. Bidirectional optogenetic manipulations revealed roles for interneurons in selecting cell assemblies through winner-take-all dynamics that go beyond simple circuit suppression.

18 hours ago 10 4 0 0

Astrocyte cell volume dynamics across cortical states and transitions Deng et al. used in vivo two-photon imaging to characterize sleep-wake-dependent changes in astrocyte volume. Using chemogenetic and optogenetic activation of locus coeruleus tyrosine hydroxylase-positive neurons, they show that norepinephrine drives these volume changes, in part via α1-adrenergic receptors.

21 hours ago 4 1 0 0

Movement-stabilized three-dimensional optical recordings of membrane potential changes and calcium dynamics in hippocampal CA1 dendrites (Neuron 114, ◼◼◼–◼◼◼; May 20, 2026)

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A bone-derived hormone permits rapid visual escape via GPR37 receptor in a subpopulation of VTA GABAergic neurons (Neuron 114, ◼◼◼–◼◼◼; May 6, 2026)

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Interpreting human sleep activity through neural contrastive learning Chen et al. collect a large human sleep dataset and develop Sleep Interpreter, a cross-domain neural decoder trained with contrastive learning to align waking and sleeping activity and read out semantic memory reactivation. It generalizes across experiments, peaks during slow oscillation-spindle coupling, predicts later memory, and supports real-time sleep decoding.

3 days ago 1 0 0 0

Risk reshapes amygdala representation of choice Piantadosi et al. show mice flexibly adjust choices between reward options based on the punishment potential in a BLA-dependent manner. They find that BLA neuronal representation of punishment reactivates during risk-related behaviors. Additionally, they demonstrate that risk sensitivity versus tolerance is predictable from the risk-related recruitment of newly encoding neurons into the choice representation.

4 days ago 2 0 0 0

SARM1 executes neuronal parthanatos and promotes excitotoxic cell death Wu et al. show that PARP1 hyperactivation activates the NAD⁺ hydrolase SARM1 to execute neuronal parthanatos. SARM1 drives mitochondrial depolarization, AIF translocation, and neuronal death following DNA damage and other parthanatos-associated insults. These findings expand the therapeutic potential of SARM1 inhibitors to additional common neurodegenerative diseases.

4 days ago 2 0 0 0

A bidirectional brain-fat body axis for pathogen avoidance How immune tissues influence brain function remains unclear. Wang et al. show that pathogen sensing recruits neuromodulatory input to the fat body, triggering fat body-derived dopamine release that modulates mushroom body output neurons to drive pathogen avoidance.

4 days ago 5 2 0 0

Top-down control of the descending pain modulatory system drives multimodal placebo analgesia Livrizzi, Chang-Weinberg, et al. identify a cortical-brainstem circuit that mediates top-down control of pain during placebo analgesia and find that pain relief is gated by endogenous opioids in the vlPAG. They find that the placebo effect extends to multiple forms of pain and that pre-conditioning promotes pain resilience after injury.

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This @cp-neuron.bsky.social neuroview paper of the brilliant @ji-joan-lin.bsky.social on the neural basis of aesthetics provides a conceptual cornerstone for an ongoing series of impressive empirical studies in which we unveil the multidimensional nature of aesthetic experience.

6 days ago 8 4 0 0

The new issue of Neuron is now online. The cover features work from Abbas Rizvi, Tom Maniatis and colleagues use STAB-seq to characterize cellular identities in the adult human spinal cord. The authors identify masked enhancers—regulatory elements that activate transcription.

5 days ago 2 0 0 0

A reciprocal glial circuit calibrates injury information and governs the tissue response balance Brain injury responses must be carefully balanced to limit damage while enabling repair. Luan et al. show that astrocytes and microglia form a reciprocal signaling circuit and achieve balanced ATP release through microglial IL-1β-mediated negative feedback, allowing the brain to calibrate injury responses and initiate balanced tissue responses.

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Dual-engram architecture within a single striatal cell type distinctly controls alcohol relapse and extinction Xie et al. reveal that opposing alcohol memories are stored in distinct groups of engram ensembles within the same striatal cell type in mice. One ensemble promotes relapse, while another supports extinction. Strengthening of cortical inputs onto relapse-driving ensembles encodes alcohol memory and can be artificially recreated to trigger relapse-like behavior.

6 days ago 1 0 0 0

Infant learning forms lasting memory schemas that influence adult behavior Bessières, Prikas, et al. report that episodic-like learning in infant mice establishes enduring memory schemas that guide adult behavior. The schema facilitates relearning and the formation of new, congruent memories in adulthood. Infantile schemas undergo hippocampus-dependent systems consolidation. While adult relearning relies on the PFC, the facilitation of new congruent memories requires PFC and top-down PFC-to-hippocampus neural projections.

1 week ago 1 0 0 0

A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina Shen et al. combine a genome-wide CRISPR screen in mice with an adult human retina model to identify broadly protective gene therapies for retinitis pigmentosa. They show that boosting UFD1 or UXT preserves photoreceptors and vision by helping the retina withstand stress from misfolded proteins.

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Human hippocampal ripples prioritize model-based learning Zhou et al. show how the human brain learns efficiently from sparse experience. Hippocampal ripples coordinate with the frontopolar cortex, a region at the apex of the frontal brain, to transform direct experience into learning that generalizes to related situations.

1 week ago 6 2 0 0

Tau seeds induce neurofibrillary tangle formation across brain regions via individual-specific connectivity Weber and Ng et al. measured tau seed bioactivity of synaptosomes from 256 postmortem samples and integrated these data with genotype and antemortem fMRI measurements from the same individuals. Multimodal analysis revealed that tau seeds drive neurofibrillary tangle formation both locally and across distal brain regions via individual-specific brain connectivity.

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Astrocytic glucose metabolism regulates the survival of newborn hippocampal neurons in the adult brain Environmental exploration prompts astrocytes to convert glucose into lactate, which supports the survival of newborn neurons in the adult hippocampus. This study identifies a metabolic partnership that links experience-driven brain activity to the survival of new neurons in the adult brain.

2 weeks ago 4 0 0 0

2P-NucTag: On-demand phototagging for molecular analysis of functionally identified cortical neurons 2P-NucTag enables on-demand and stable two-photon phototagging of single neurons following in vivo functional imaging in behaving mice. It reveals unexpected gene expression differences between hippocampal “place” and “silent” cells, connecting functional identity to molecular and physiological mechanisms.

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Presynaptic P/Q calcium channel deficit promotes postsynaptic excitability remodeling and neurogenesis in developing thalamic circuitry Thompson, Miao et al. trace developmental changes in thalamocortical excitability due to P/Q calcium channel dysfunction in a mouse model of childhood absence epilepsy. Coordinate elevations in downstream ion channel and WNT-signaling genes regulating rebound bursting and thalamic neurogenesis that begin in utero disrupt circuit homeostasis related to epilepsy and attention.

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Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion Plitt and Kaganovsky et al. examine how postsynaptic membrane fusion controls hippocampal computations during behavior. By performing in vivo calcium imaging after deleting Syntaxin3 in CA1, they show that novelty-associated activity and the formation of stable reward-relative representations require Syntaxin3, but core spatial and contextual place coding remain intact.

2 weeks ago 7 0 0 0

New work from our team, led by the incredible
@emily-hill.bsky.social out today
@cp-neuron.bsky.social. Including some exciting additions from our prepint. Thread below! authors.elsevier.com/a/1ms0u3BtfH...

3 weeks ago 22 11 1 0

New paper out in @cp-neuron.bsky.social 🎉

What determines contextual modulation in V1? Why does the visual surround sometimes facilitate and sometimes suppress a neuron's response to its preferred stimulus?

3 weeks ago 67 31 2 0

New issue of Neuron is out! The cover features work from Eunji Cheong, Jaewon Ko and colleagues and identify LRRTM3 as a molecular gatekeeper of synaptic remodeling in the mouse thalamic reticular nucleus, highlighting an understudied area in development.

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