The Pain Research Forum is launching a new monthly Webinar Series. The first event is this Wednesday Jan 14th, 2026 at 12 PM ET. Register using the QR code or visit painresearchforum.org @usasp.bsky.social @dimacd.bsky.social @psalmotoxin.bsky.social @iasp.bsky.social @dimacd.bsky.social
Your annual reminder that the most revealing difference between Irish and Scottish Gaelic is definitely in the words for December: Mí na Nollag (Month of Christmas) in Ireland, and An Dubhlachd (the Blackness) in Scotland. So once again may I wish you all a lovely Blackness.
Still amazing that a specific language impairment can be mapped to a mendelian single gene mutation. Reading about this discovery of a "language gene" is what first got me interested in biology, genetics and ultimately neuroscience!
Enjoyed this gig. Or as they're known in the UK: Maudlin-a Bay...
Congrats Ewan, very interesting and not necessarily what I would have expected. It would be interesting to sequence these DRGs!
ATV catching big air, labelled "neuropeptides."
"The connectome is like a road map."
Really enjoyed this great book telling the story (and experiments) behind our understanding of the hypothalamus, neuron coding, and 'wireless' neurochemical signaling (oxytocin, prolactin etc)... mitpress.mit.edu/978026255193...
Thank you, that makes sense!
This is a great and interesting paper, congrats! I had one question re the heat map in Fig 2C. How should we interpret the channels that are not found in the peripheral terminal, but are present in the other compartments e.g. Scn9a. Is it really absent or just not detected or hidden by the scaling?
Congratulations, this is a phenomenal paper and one to which I referred many times starting out in the field as a phd student!
Some very nice 50 year old immunostaining that showed for the first time that Substance P was in sensory neurons and their central terminals. Only three pictures, published in Science! www.science.org/doi/abs/10.1...
different coloured mice on a white background
Turns out, two of pain’s most famous messengers — Substance P and CGRPα — might not be so essential after all. Mice missing both still felt pain just fine, challenging decades of assumptions about how pain signals travel.
buff.ly/ypISrtx
In science, we don’t give negative data nearly enough love. Showing with genetic precision that CGRP and Substance P aren’t needed for different kinds of acute and chronic pain? That’s huge.
Its very exciting. I think we still lack fundamental understanding of how these local efferent effects work. What drives release of the peptide? Is it always spike dependent? Can this happen without APs propagating up to DRG and dorsal root to cause sensation/pain? Can the signals go in reverse?
Come join our lab as Postdoctoral Fellow! The project will investigate the maturation of spinal circuits and their plasticity within chronic widespread pain states.
Apply here: www.ucl.ac.uk/work-at-ucl/... until 11th April.
@ucllifesciences.bsky.social @uclnpp.bsky.social @jobrxiv.bsky.social
I think the amazing thing about patch clamp is it hasn't really ever been superseded as the gold standard to study ion channel function. I think people will still patch 50 years from now !
That's one way to tarnish the Ramon y Cajal name!
This is very interesting. These neurons seem highly similar to the SST/NPPB/OSMR neurons whose activation can drive itch pubmed.ncbi.nlm.nih.gov/34757808/
Thank you for sharing our updated preprint, the results surprised me as much as everyone else!
This study challenges traditional views of pain biology by showing that deleting Substance P and CGRPα does not affect acute or chronic pain in mice, underscoring the complexity of finding effective pain targets.
www.biorxiv.org/content/10.1...
What I really admire about LeDoux's books is that he changed his mind about whether his pioneering rat fear conditioning studies were actually studying fear at all! And then criticized the field he basically started to highlight the differences between animal instinctual behaviours and human emotion
The book is great. I was amazed at the crazy hours and single minded dedication at the rig it took to make some of his early discoveries...And I just clocked the forward is by the also remarkable Nancy hopkins, really recommend The Exceptions about her campaign at MIT!
Very excited to read this once it comes out!
Quite a find! Need to order this one!
