Each publication in a #Microbio26 journal helps fund 4 student travel grants. Please publish with us if you can!

Hope for control of a centuries-old epidemic After decades of stagnation, a renewed push in tuberculosis research is expanding the drug and vaccine pipeline to bring one of humanity’s oldest and deadliest infectious diseases under control.

Hope for control of a centuries-old epidemic www.nature.com/articles/d41...

Recombinant Mycobacterium smegmatis producing a functional M. tuberculosis ESX-1 system is protective in the murine model of bovine TB without sensitization to tuberculin Bovine tuberculosis (bTB) is a chronic, productivity-limiting infection in livestock with significant zoonotic potential that is caused by members of …

www.sciencedirect.com/science/arti...

I am delighted to share the latest study on our bTB vaccine. Grateful to Beef Cattle Research Council for the support 🙏

Joe Humphreys: Four stories that Albert Camus might choose to tell if he were alive today Author’s speech 80 years ago, on how ideology is used to excuse or celebrate death, feels suddenly current

Four stories that Albert Camus might choose to tell if he were alive today

www.irishtimes.com/opinion/2026...

The #BirdOfTheDay theme is #BestOfTheMonth

Love how this little guy turned out

#Robin
#photography #photographic #photographers #Birds #Wildlife #Ireland
#blueskybirds
#birdsofbluesky #nature
#EastCoastKin

Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair - The EMBO Journal Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitm...

💥Our latest @embojournal.org on membrane damage and repair. Di @dichen02.bsky.social @crick.ac.uk found that calcium is a conserved signal for ATG8/LC3 lipidation on membranes using novel probes to record calcium leakage. Congratulations Di et al!
link.springer.com/article/10.1...

One of the deadliest diseases in history is still here. TB kills 1.3M people every year.

On #WorldTBDay, VIDO researchers are advancing vaccines, drug targets, and new models to help stop TB.

Read more: www.vido.org/news/2026/ad...

@usask.ca @jeffchenmycolab.bsky.social

#WorldTBDay #TB

All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy?

Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation.

www.nature.com/articles/s41...

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Bert W. O’Malley (1936–2025): A great scientist, mentor, and proud Irishman | PNAS Bert W. O’Malley, the “father/grandfather” of the field of molecular endocrinology passed away on November 11, 2025, at the age of 88. In a disting...

Bert W. O’Malley (1936–2025): A great scientist, mentor, and proud Irishman | PNAS www.pnas.org/doi/10.1073/...

The #BirdOfTheDay theme is #tricolour
#starling
#photography #photographic #photographers #Birds #Wildlife #Ireland
#blueskybirds
#birdsofbluesky #nature
#EastCoastKin

You could say that Rock n Roll was born 111 years ago today in Arkansas, but probably not where you'd think. Before there was a Chuck Berry or Little Richard, there was those who wanted to be like her.

Rosetta Nubin better known as Sister Rosetta Tharpe, the godmother of Rock was born on this day

“Measures to strengthen international biosafety and biosecurity practices”

There is an absolute necessity for research on ‘pandemic-prone pathogens’. Studies must, however, be conducted responsibly & according to strict principles of safety & security

This outlines steps for global accountability

Acidic pH Restricts Non‐Tuberculous Mycobacteria Replication Different nontuberculous mycobacteria (NTM) species display unique replication profiles in acidic pH in vitro which correlates to their replication within human macrophages. Inhibition of the acidic ...

Very happy to see this out! Great work by @lockwop.bsky.social @crick.ac.uk and first paper on NTMs from the lab! Parise made a set of 12 fluorescently labelled NTMs covering environmental and opportunistic mycobacteria...
onlinelibrary.wiley.com/doi/10.1111/...

I’m pleased 🤗 to share our new preprint exploring the mode of action and resistance of the antitubercular drug pyrazinamide (PZA) 💊 Thanks to everyone who have participated 🙌
We hope these findings will help the fight against drug resistance in tuberculosis.
www.biorxiv.org/content/10.6...

#OnThisDay in 1938, American evolutionary biologist Lynn Margulis was born. Margulis is most known for developing and popularising the endosymbiotic theory, which explains how eukaryotic cells evolved organelles from simpler prokaryotic organisms that resided within another and became incorporated.

The #BirdOfTheDay theme today is #SideView

The elusive jay.

#photography #photographic #photographers #Birds #Wildlife #Ireland
#blueskybirds
#birdsofbluesky #nature
#EastCoastKin

The human right to a healthy, clean & sustainable environment could be a game changer for tackling #AMR's environmental drivers. But how could this work? Wendy Boucrot, Sheila Varadan & I review how the new right could be applied to #antimicrobial pollution.

doi.org/10.1017/pub....

#STS #HistMed

I'll swim the seas inside with you
And like the waves, without a sound
I'll never let you down

#Ireland #Mayo #WildAtlanticWay
#photography #photographie #photographers
#EastCoastKin

On #RareDiseaseDay, we recognise the leadership of Dr Cormac McCarthy, whose voice continues to raise research impact & awareness of Lymphangioleiomyomatosis (LAM). . #clinicaltrials

Patient partnership drives progress.

@ucdmedicine.bsky.social @ucddublin.bsky.social

Unrooted phylogeny indicating the major clades of Mycobacterium bovis found in Ireland.

The genomic diversity and spatial patterns of Mycobacterium bovis in Ireland revealed by whole genome sequencing rdcu.be/e50zT

Recovering Mycobacterium tuberculosis 🦠 from ancient samples is notoriously difficult. But, in this new study, the elusive M. tuberculosis DNA was detected in five individuals from medieval Ireland.
doi.org/10.1016/j.tu...
#MetagenomicsMonday #SPAAM #aDNA #paleogenomics #tuberculosis #TB #pathogen

Can safely way this is the craziest and coolest study I have led. We chart the evolution of sheeppox virus, finding it in the Eurasian steppe ~3700 years ago, and also in a LOT of parchment from medieval Europe (made from a range of animals skins!) #aDNA

Bacterial defense systems and host ecology drive the evolution of intra-species lineages Staphylococcus aureus lineages vary widely in the frequency of gene exchange and the diversity of genome content. Gorzynski and Harling-Lee et al. show that both host ecology and the horizontal acquis...

Great work by Jamie Gorzynski and Josh-Harling-Lee from the group providing insights into the evolutionary origins of bacterial lineages. A collaboration with @jrpenades.bsky.social @wfigueroac3.bsky.social. #Staph Cell Reports www.cell.com/cell-reports...

Beautiful and solid work on trehalose monomycolate synthesis in mycobacteria by @figlegend.bsky.social lab. Check it out folks. Also, for the non-enzymologists, product inhibition is a thing, and actually does matter. 😜

www.pnas.org/doi/10.1073/...

Myeloid core of TB granulomas is partitioned into two distinct metabolic environments, one of which is hypoxic & associated with pathological immune cell states that subvert immunity to TB @natimmunol.nature.com @erin-mccaffrey.bsky.social
www.nature.com/articles/s41...

Good god Ireland are great

Bacterial metabolic remodeling by convergent evolution unlocks nutrient availability after a host switch Staphylococcus aureus has undergone metabolic remodeling to adapt to the dairy niche.

Insights into how #Staph aureus adapts to the bovine host by unlocking nutrients from the dairy niche. Great work by Amy Pickering, Jamie Gorzynski and others in the group. Bacterial metabolic remodeling by convergent evolution after a host switch.|Science Advances www.science.org/doi/10.1126/...

In the largest study of its kind, scientists in the Bork Group at EMBL have found that a small subset of microbes can carry and transfer genes across disparate habitats, creating a planet-wide, interconnected network of microbiomes 🌍 🦠

🔗 Read more here: www.embl.org/news/science...

Congrats to @aschwalbc.bsky.social for bringing this work to the finish line!

Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature Communications Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...

We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.

www.nature.com/articles/s41...

A thread.