Acetylhistidine in our blood can prevent kidney disease and is produced by the HisAT (NAT16) enzyme displaying a rare double-GNAT structure. Great efforts by Matti Myllykoski and the rest of the team at @unibergen.bsky.social to get this published. #acetyltransferase www.nature.com/articles/s41...

Thanks Sjon! Unfortunately not! I wish I could join, it sounds like a great meeting, but I’ve moved away from plant work for the time being. Hopefully we can catch up soon!

An mRNA-display derived cyclic peptide scaffold reveals the substrate binding interactions of an N-terminal cysteine oxidase - Nature Communications This work identified cyclic peptide inhibitors of a mammalian N-terminal cysteine oxidase, ADO, through mRNA display, one of which was used as a scaffold to graft substrate moieties, allowing key inte...

Oxygen sensors structurally defined. The substrate binding of N-terminal cysteine oxidases uncovered by the White lab @drmdwhite.bsky.social in @natcomms.nature.com www.nature.com/articles/s41...

A huge thank you to my amazing team and collaborators from @sydney.edu.au

These findings will facilitate the discovery of chemical tools to manipulate the N-degron pathway in the context hypoxic disease and crop flood tolerance.

We identified cyclic peptide inhibitors of the mammalian NCO, ADO, through mRNA display, one of which was used as a scaffold to graft substrate moieties, allowing key interactions to be assessed through structural and biochemical approaches.

An mRNA-display derived cyclic peptide scaffold reveals the substrate binding interactions of an N-terminal cysteine oxidase - Nature Communications This work identified cyclic peptide inhibitors of a mammalian N-terminal cysteine oxidase, ADO, through mRNA display, one of which was used as a scaffold to graft substrate moieties, allowing key inte...

I’m very excited to share our latest publication characterising the substrate binding interactions of an N-terminal cysteine oxidase (NCO), out now in @natcomms.nature.com!

doi.org/10.1038/s414...