Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.

#medicalresearch #pain #arthritis | Teodora Trendafilova, PhD I am very happy to be advertising the position below for a post-doc to join me and Franziska Denk at King’s College London, Wolfson SPaRC (Sensory, Pain and Regeneration Centre). It’s a very exciting...

We are hiring! www.linkedin.com/posts/teodor...

Years ago @mikeduncan.bsky.social told me "you can rewrite shit but you can't rewrite nothing" and it's made every draft easier since.

Annette Dolphin obituary Other lives: Neuroscientist whose research showed how individual molecules can affect neurological disorders

Obituary of Annette Dolphin @annieneuro.bsky.social written by her sister in The Guardian. www.theguardian.com/science/2026...

Hebb, is that you?

Wow, browsing through this paper, it looks like a massive game changer! Congratulations to Felix and the team!

Curious too! Voltage-gated sodium/calcium channels have 24 TM segments, but not sure if they’re considered grouped as 4 repeat TM domains?

We are looking for a postdoctoral scientist to work on challenging and exciting neuroproteomics problems. Close collaboration with @coscialab.bsky.social Apply: jobs.helmholtz-hzi.de/job/Braunsch...

Deep visual proteomics uncovers nociceptor diversity and pain targets - Nature Communications Sensory neuron subtypes are defined by transcriptomics, but their proteomic identities remain unclear. Here, authors show distinct protein signatures of electrophysiologically defined nociceptors and ...

Excited to share our new @natcomms.nature.com study with the @garyrlewin.bsky.social lab and @amapruns.bsky.social. Using deep visual proteomics, we created the first neuronal subset-resolved proteomic map of sensory neurons with potential implications for pain treatment.
go.nature.com/481nr4R

Screenshot of article

Where are the women’s health drugs?
www.nature.com/articles/d41...

Wendy Young, an advisor at Google Ventures and former head of small-molecule drug discovery at Genentech, discusses the dearth of women’s health drug discovery programmes

Are you curious about “pain resilience” genes and how to become a successful scientist in the pain field? Listen to the newest episode of the IASP-PRF podcast, featuring Stephen Waxman bit.ly/4sZYorv #PRF #podcast #neuroscience #pain

Three-year funded postdoctoral fellowship for scientists returning after a 12-month career break, deadline May 17, 2026.

The LMB is proud to launch the Career Returner Fellowship, a three-year, fully funded postdoc placement for scientists who have had a career break of over 1 year.

Applications are open now!

More details: mrclmb.ac.uk/careers-and-...

Please share this post with anyone who may be interested!

Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons BDNF promotes axon-regenerative gene expression, RNA metabolism, and kinase signaling in motor neurons.

Congrats to Jobert, Anna-Leigh, and Kai on showing how #BDNF amplifies #transcription, coordinates #RNA dynamics, and spatially regulates the #phosphoproteome.

Beautiful cover art too!

@jamessleigh.bsky.social @frattalab.bsky.social @uclqsion.bsky.social

Mapping nerves in a whole embryos.

We find that across species and development stages, embryonic nerves display (beautiful) fractal geometry.

More here: www.biorxiv.org/content/10.6...

Postdoctoral Research Associate (PDRA) | King's College London

We have an exciting opportunity at Wolfson SPaRC for a Postdoctoral Research Associate to join our work on the neurobiology of arthritis pain. A great role for researchers interested in neuroscience, advanced imaging, and collaborative science!
www.kcl.ac.uk/jobs/142825-...

Don’t Perish! A Step-by-Step Guide to Writing a Scientific Paper (2026 edition) Great science deserves to be read — not buried under unclear writing. This is the updated 2026 edition of your favorite guide to writing…

I just published Don’t Perish! A Step-by-Step Guide to Writing a Scientific Paper (2026 edition)

Great science deserves to be read—not buried under unclear writing. This is the updated 2026 edition of your favorite guide to writing scientific papers.

medium.com/p/dont-peris...

How important do you feel discovery research and ‘basic’ science is for understanding disease? Well, I have a little bit of a biased view on the topic, since I'm a basic scientist myself. The lab has made more and more discoveries with very strong therapeutic implications, and often people ask me why we are not pursuing these further ourselves. Part of it is that I think about this very much as an ecosystem. People have different skills – I have colleagues who are very good at the application side of things and I have other colleagues, including people in my lab, who are very good at the basic science. There are a lot of very smart people at every stage in the ecosystem and, sometimes, we have to acknowledge that we can't all be experts in every step. A lot of basic science discoveries will end up having profound implications in the clinic – if you don't have the full imagination about how to get it there, that's okay, because you're still a very important piece of the jigsaw puzzle and other people can help. If the basic science discoveries didn't exist, then it's quite possible that the well would run dry. We cannot simply rely on the idea that the therapies currently in clinical trials are going to be enough because we already know that – for diseases, such as cancer, and with rapidly evolving viruses – there needs to be a constant influx of new ideas to stay ahead of the arms race. I'd also make a plug for the fact that, ultimately, we are all interested in human disease, but disease research in humans is not ethical or possible. This is why creating and studying model organisms in a high-throughput, low-investment context is incredibly important. We cannot just say ‘okay, we're going to stop work on anything that is not related to human research’, because – actually – it's all relevant to humans.

Do you think basic science is particularly threatened by cuts to funding? Science itself is quite uncertain. We do experiments wondering if they will even work. It's discovery, and you don't know where it's going to lead. It could lead to a billion-dollar company, something like mRNA vaccines or CRISPR-Cas9 gene editing, or it could simply be something that interests you. Sometimes it might appear esoteric from the outside, but there are very smart people dedicated to this work. We shouldn't lose sight of the fact that most of this work is paid for by taxpayers, but funding uncertainty creates a very unstable foundation. If the foundations are weak, people are going to get much more conservative about the science that they're doing and worry that ‘blue-skies research’ is not worth pursuing because it won't get funded. And that would be a mistake because all innovation in science really originates from blue-skies, basic research. The second thing that uncertainty does is send a message to our young trainees – who are our future – that this is not a career option that will provide professional and personal stability. I worry that this kind of uncertainty will mean we lose an entire generation of people, and that would be a loss we might not be able to overcome.

I was interviewed by @katiepickup.bsky.social recently for @dmmjournal.bsky.social. This has a little bit of my background, a little bit on science and mentoring, and a little bit (ok, more than a little bit) on funding in science.

Check it out at: journals.biologists.com/dmm/article/...

IN THIS ECONOMY???

Point of View: An easy way to improve lab meetings Sharing positive and negative experiences at lab meetings can make a career in science a little less hard, a little more pleasant, and a little more human.

Point of View: An easy way to improve lab meetings doi.org/10.7554/eLif...

I'm really happy to see this one out @elife.bsky.social. Awesome Cara Glynn and I describe and reflect on a year-long, low-cost practice that transformed our group meetings.

#researchculture #ECR #labmeetings

"Carrot in a Box" Jimmy Carr IN TEARS After Game with Sean Lock & Jon Richardson! | 8 Out of 10 Cats YouTube video by E4

Blinding samples for a collaborator will always make me think of this 🥕🎁🤔

m.youtube.com/watch?v=0UGu...

A great #PaimResearch listen for all voltage-gated sodium channel fans 😃👇

In Figure 2 we describe how we would propose triaging non-coding variants (NCVs), as a step towards generating evidence supporting pathogenicity and disease causation, currently not addressed in clinical genomic diagnostics.

🔎 Browse extensive libraries of protein structures in Jalview using the 3D Beacons Network. Once imported, these can be colored, superimposed and viewed in 3D in conjunction with alignments.

👓 Synced views provide precision and clarity, allowing you to hone in on regions of importance.

🦴 Living with arthritis pain?

We’re starting a new project on arthritis pain and want to learn from your experience.

👉 Which movements trigger or worsen your pain?

Please take a few minutes to complete our short survey:
forms.office.com/e/qv0tx9LJ1L

Your input will help guide our research.

Actually, what is a gain-of-function mutation? Abstract. For more than a century, scientists have worked to characterize, understand, and predict the consequences of mutations. For almost as long, scien

academic.oup.com/genetics/adv...

Also thanks to Lyndall & @psarkies.bsky.social, @ahocher.bsky.social, and members of the lab for their comments and Francis Barr @oxfordbiochemistry.bsky.social for encouraging me to write down my thoughts. 2/2

9pm Switzerland time, y'all! I'll be talking about how neurons are like onions. Tiny onions.

Sort of. Look, you'll have to be there 🧪🧅🐟

MRC: research grant: applicant-led Apply for funding to support exciting and ambitious research within the remit of the Medical Research Council, to transform our understanding of human health and disease

A welcome and much needed reopening of pplicant-led grants today at MRC, with no closing date.
It brings massive changes to assessment, with more details now available. Focus is on evaluation by a "college of experts" but its composition is still not clear. 1/6

www.ukri.org/opportunity/...

You have more in common with the people of Iran than you do with anyone in this administration, any member of the technocracy, anyone who is profiting from this war, or any billionaire. When you see Iranians forming human chains outside key infrastructure sites, you should feel a sense of kinship.

The root of pan-adaptationism? There’s been a fair bit of recent discussion about why most biologists are (uncritically) adaptationists. I don’t dispute this but think it’s worth reconsidering why. Some have argued that this is bec...

We should all do our part to join Brian in ending genetics essentialism. I give a lecture at Pitt to the new PhD students entitled "There is no such thing as wild-type."

I blogged about this years ago and it's part of my teaching statement.

Long road, team effort✊🏻
micropopbio.org/blog/2018-07...

Missed this part of SciTwitter discussions that led to getting a fuller view of genetics - thanks for sharing, this is a great point!