“Emerging roles of tRNA modification-mediated codon-specific translational reprogramming in cancer biology”
This review dissects 18 tRNA-modifying enzymes and their role in regulating codon-biased translation in cancer ⤵️
www.nature.com/articles/s41...
“Transcriptome analysis of the prefrontal cortex identifies inflammatory genes associated with cognitive impairment in a model of multiple sclerosis”
Study from Prof. Sette’s lab identifies potential markers for MS-related CI ⤵️
www.nature.com/articles/s41...
“Mitofusin-2 suppresses tumor immune escape through EGFR/STAT3-mediated PD-L1 transcription”
Explore this emerging link between mitochondrial dynamics and tumor immune evasion ⤵️
www.nature.com/articles/s41...
“FAAH initiates a positive feedback loop to promote lung adenocarcinoma progression through inhibition of ferroptosis”
Read more about FAAH as a prognostic biomarker and a potential therapeutic target for lipid metabolism-related malignancies ⤵️
www.nature.com/articles/s41...
"Targeting CAFs-derived PCSK6 inhibits redistribution of PD-L1 and restores response of CD8+T cells against colorectal cancer"
Read more about this specific subtype of CAFs involved in immune suppression and CRC progression ⤵️
www.nature.com/articles/s41...
“p63 in skin homeostasis and disease: molecular mechanisms and therapeutic potentials”
A comprehensive overview of p63 and its core functions in skin biology:
www.nature.com/articles/s41...
“HECT ubiquitin ligases as regulators of inflammatory signalling”
In this timely and well-organised review, Prof. Sharad Kumar and colleagues provide insights into how ubiquitin signalling shapes inflammation and disease. ⤵️
www.nature.com/articles/s41...
“Signaling scaffold Shoc2 regulates lymphangiogenesis by suppressing mTORC1-mediated IFN responses”
Find out more about this novel mechanistic link between the Shoc2 scaffold, mitochondrial function, mTOR signalling, and innate immune response ⤵️
www.nature.com/articles/s41...
New paper from the lab out in Cell Death & Disease
@cddpress.bsky.social @cbm-csic-uam.bsky.social
"Transcription-dependent and -independent functions of Drosophila p53 isoforms in the induction of apoptosis and senescence-associated tumorigenesis.” #p53 #Drosophila Thread 1/9👇👇👇
“The cGAS-STING pathway in cancer: friend or foe”
Check out this review in CDDIS:
www.nature.com/articles/s41...
“PINK1 and STUB1 pathway orchestrates peroxisomal selective autophagy by PEX13 depletion”
Read this fascinating work highlighting how the ATM-PINK1-STUB1-ABCD3-SQSTM1 axis modulates pexophagy and peroxisomal quality control ⤵️
www.nature.com/articles/s41...
"STING is the scaffold protein for stress granule pre-condensation at the ER"
Read more about this novel and non-canonical function of STING here:
www.nature.com/articles/s41...
Novel insights for GBA1-PD treatment strategies:
“GBA1 F213I mutation increases the expression of LCN2 promoting neurodegeneration” ⤵️
nature.com/articles/s41...
Join us at the 32nd ECDO Conference
“Death on the Beach: Cell Death & Disease” 🌊
📍 Favignana, Italy
📅 Sept 16–19, 2026
3 Nobel Laurates, 4 days of science, networking & Mediterranean vibes 🇮🇹
Don’t miss it!
#ECDO2026 #CellDeath #ScienceSA
ecdo2026.com
"Extracellular GPX4 functions as an immunosuppressive DAMP in ferroptosis”
Read this comment on CDD ⤵️
www.nature.com/articles/s41...
“Targeting the PSMD14-BCKDK pathway overcomes immune suppression and enhances CAR-NK infiltration in glioblastoma” ⤵️
www.nature.com/articles/s41...
“DR5/WDR12 balances p65 stability promoting sunitinib resistance in renal cell carcinoma” ⤵️
www.nature.com/articles/s41...
“Znhit3 regulates p53/p21 signaling and governs cerebellar granule cell development”
Online in CDD: www.nature.com/articles/s41...
“Targeting WIP1 reprograms immunosuppressive tumor microenvironment to potentiate immunotherapy response in colorectal cancer” ⤵️
www.nature.com/articles/s41...
“Caspase-8-mediated CYLD cleavage boosts LPS-induced endotoxic shock” by Prof Haibing Zhang and colleagues ⤵️
www.nature.com/articles/s41...
And do not miss its Editorial, written by Prof Douglas R. Green
“Caspase-8 comes in from the CYLD” ⤵️
www.nature.com/articles/s41...
"Targeting the C/EBPβ-PRAME-EZH2 complex modulates the Netrin-4/AKT axis to inhibit renal cancer tumorigenesis and metastasis" ⤵️
www.nature.com/articles/s41...
Along with its Editorial, written by Prof. Salomoni ⤵️
www.nature.com/articles/s41...
“Modulation of immune cells and metabolic reprogramming in efferocytosis”
Check out this review on CDDIS: www.nature.com/articles/s41...
“Ubiquitination of MEIS1 by MDM2 serves as a switch for p53 stabilization and DNA damage response activation“ by Gang Yin and colleagues
Now on CDD: www.nature.com/articles/s41...
“Amyloid-β and Tau in Alzheimer’s disease: pathogenesis, mechanisms, and interplay”
Find this timely review by Dr Domenico Praticò et al. here: www.nature.com/articles/s41...
“Gut-derived hyodeoxycholate reprograms the spleen–eye immunometabolic axis to suppress autoimmune uveitis”
Check out our latest work on CDD, the result of a great collaboration between Wei Jia, Xiaolu Yang, Aiping Lu, and Gerry Melino.
www.nature.com/articles/s41...
“Phagocytosis of necroptotic cells optimizes type 1 conventional dendritic cells for induction of a cytotoxic T-cell response” from Dr. Jannie Borst’s lab
Read here: www.nature.com/articles/s41...
“HIF2α-induced lysyl oxidase safeguards successful pregnancy by remodelling collagens at the feto-maternal interface”
Read this new paper by Yasushi Hirota et al. now on CDDIS: www.nature.com/articles/s41...
“Functional genomic screens uncover FERMT2 as a critical regulator of YAP/TAZ-driven tumorigenicity”
Check out this new paper by Campaner et al. www.nature.com/articles/s41...
