A quadratic paradigm describes the relationship between phenotype severity and variation - Nature Communications Phenotype variation is higher in mutants than wild types. Examining a range of mutant severities, this study unexpectedly found that variation decreases in severe conditions. A quadratic trend best fi...

Lots of great discussion about developmental variability here at #GastrulationReloaded! Super important to consider, and current tools have the power for this.

Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...

Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

This preprint is now out after peer review! Check it out: www.cell.com/cell-genomic.... Huge congrats (and thanks!) to the whole team that contributed!

#zebrafish | Kevin Thiessen, Ph.D. A while back, I put together a Bioinformatics Bootcamp for #zebrafish researchers. Here are some of the helpful links & resources that I've come across in my search: Disclaimer: This is not a...

Cross-posting from LinkedIn: www.linkedin.com/posts/kevin-...

These are useful (and free!) websites that I found in my search for all things #zebrafish as part of my Bioinformatics Bootcamp. If there’s enough interest, I may do a blog post on the Node. Enjoy!

Mice grow bigger brains when given this stretch of human DNA Finding adds to the bigger picture of how humans developed such large brains.

Taking a snippet of genetic code that is unique to humans and inserting it into mice helps them grow bigger brains than usual

https://go.nature.com/3GOTQkz

A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

Our review describes the landscape of human-specific loci and the recent methods developed to probe their function in brain development. It was a pleasure to work with
@debbysilver.bsky.social and PhD student Missy Lollis to explore the current status of this rapidly evolving field!

Excited to see this collection in print! www.sciencedirect.com/special-issu...
Check out our most recent review from the Silver Lab - "How our brains are built: emerging approaches to understand human-specific features".