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Posts by Derek Lowe

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Cancel the White House Correspondents’ Dinner Trump will be guest of honor at the “nerd prom,” with journalists serving as suck-ups

Journalists planning to honor Trump at the White House Correspondents’ Dinner have a choice:
A. Party with the dictator, wear fancy clothes and network to boost their careers.
B. Stand up for democracy by staying home.
They’re going to choose A. It looks terrible now. It will look worse to history.

2 hours ago 545 149 33 9
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Why Are People Injecting Themselves with Peptides? Health and wellness influencers are hawking unapproved treatments on the gray market. The future of the F.D.A.—and the health of consumers—is at stake.

Top notch and terrifying piece about this in the @newyorker.com Unbelievable what was allowed BEFORE MAHA
www.newyorker.com/magazine/202...

4 hours ago 10 4 0 0

this is an important report. MAHA political advocacy is ineffectual and largely irrelevant in its biggest election fight.

this is why some of us have been saying MAHA isn't really a political movement with coherent beliefs as much as it is a brand for marketing what everyone's selling.

14 hours ago 47 8 2 0

Spared me the trouble there

16 hours ago 3 0 1 0
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Ah, Peptides. Where to Begin?

Like most drug discovery researchers, I’ve been watching the “peptides for everything” craze with a mixture of amusement and alarm:

17 hours ago 59 22 5 5

Likewise. I think it should be legal, but I hate the smell and will never be a customer.

18 hours ago 3 0 0 0

Hey, UC Berkeley chemistry department: C&EN would like to hear from you. DM, or signal Laurel_Oldach.07

(amplification appreciated!)

20 hours ago 12 22 2 1

1 year ago today I was terminated by DOGE from USAID where I worked to get humanitarian aid into Gaza. Everyone I knew across almost 10 years of my career across 3 prior jobs became unemployed as well. My entire LinkedIn network suddenly became "open to work"

I'm a one issue voter. Punishment.

23 hours ago 1973 349 1 12

This is a reminder that you can still ask real people for advice and recommendations. You don't have to ask the robot for everything. In fact there are some things you definitely should not be asking the robot about.

21 hours ago 100 32 1 0
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Agree completely. This looks like a variation on good ol' staurosporine, which hits half the kinases known to man. This compound is great news, but surely not because it's some sort of selective inhibitor.

1 day ago 38 4 4 0

My wife and I ended up seeing the 2024 eclipse just outside of Llano, TX, which I was not prepared to hear called “Lawn-o”

2 days ago 7 0 2 0
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Federal judge unloads on ‘unserious’ RFK Jr., says anti-trans policy showed his ‘cruelty’ Judge Mustafa T. Kasubhai vacated the “Kennedy Declaration,” finding it unlawfully attempted to override medical standards and restrict care for transgender youth.

Breaking: HHS’s ban on gender-affirming care is struck down. Rarely have I read a ruling this sharply worded.

“This case is one of a long list of examples of how a leader’s wanton disregard for the rule of law causes very real harm to very real people.”

www.advocate.com/politics/nat...

2 days ago 11248 3934 6 231
A fair-skinned red-head person who has discovered he has a predisposition for melanoma only after unleashing AI agents on his genome.

A fair-skinned red-head person who has discovered he has a predisposition for melanoma only after unleashing AI agents on his genome.

2 days ago 197 29 18 17

If this actually happens, it may rank as the single most corrupt act in the history of American politics. I cannot believe this is even under discussion.

3 days ago 3978 1087 68 22
Science | AAAS

Derek once again equivocating on anti-amyloid antibodies as an Alzheimer's therapy:

"I do not see why these antibodies should be on the market."

"Do something else! For God's sake, do something else."

www.science.org/content/blog...

3 days ago 41 11 4 0
A neurosciencenews.com (real site? Who knows? I immediately wrote them off as garbage) article about a nasal spray that might reduce dementia illustrated with a profile of a nose with smoke emanating from the tip.

A neurosciencenews.com (real site? Who knows? I immediately wrote them off as garbage) article about a nasal spray that might reduce dementia illustrated with a profile of a nose with smoke emanating from the tip.

Pro tip to all the science publications out there: I will probably begin to think about taking you seriously when you quit using AI to illustrate - and apparently edit - your articles. No human thinks this depicts a nasal spray.

3 days ago 220 42 11 3

this is about as devastating sound bytes can get for both rfk jr. and trump — and on the day the cdc nomination is supposed to dominate the news cycle. rfk jr. might get in serious trouble with the white house for this one

4 days ago 101 23 3 0
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I’m looking for an automated way to read others’s scientific data without giving credit or acknowledgement, and also claim full credit for insights from it. And I want it to have a fitting name

OAI: say no more

4 days ago 829 322 10 6

Looks like the Dark-Eyed Junco birds have finally left the neighborhood here in Eastern MA. They show up in the fall from Canada; this is their Florida, the little weirdos.

I've been watching every day. Tuesday they were around. Yesterday I saw only one. And today none. Au revoir until October!

4 days ago 28 0 7 0

I don't have access myself! But I am not optimistic. . .

4 days ago 2 0 0 0
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A New Opioid Agonist?

The possibility of an opioid pain-relief compound with fewer side effects and lower addiction potential. Let’s hope it pans out:

4 days ago 29 5 1 1

This is the horrible secret sauce behind some of Trump’s public supporters, not to mention his enemies. If you turn against him, the death threats start.

It’s no way to run a country.

4 days ago 42 15 1 2

But you can’t always read the references it quotes, because some of those references are not even real.

5 days ago 8 0 1 0

Weirdly enough, I have worked with aqueous hydrofluoric acid, albeit carefully. What I won’t touch is its anhydrous gaseous form, HF. Nasty stuff!

5 days ago 5 1 1 0
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Many egs of impt drug effects discovered by "happy accident"-but not everything! GLP-1/wt loss, despite what an otherwise good science writer says in NYT op-ed, NOT an eg. known from earliest days. I discussed in 2024 -> timmermanreport.com/2024/05/the-... @dereklowe.bsky.social @thgoetz.bsky.social

5 days ago 6 1 1 0

I wear the most boring clothes imaginable, TBH.

5 days ago 1 0 0 0

This is the tricky part for me. Even if I study up on them, the small changes you describe are not things that I’ve ever tended to notice much. I also wonder how many other people pick up on them themselves? Admittedly they’re not all as oblivious as me!

5 days ago 9 0 1 0

www.semafor.com/newsletter/0... (scroll down)

5 days ago 2 1 0 0

It’s pretty much Craig Claiborne’s, but he’s generally a reliable source. Actual Hungarians have told me it’s pretty sound.

5 days ago 1 0 0 0

First time I heard “Surf’s Up”, I thought yeah, Brian Wilson was indeed losing his mind. But that ending/coda hit me out of the blue and raised the hair on the back of my neck!

5 days ago 6 0 0 0