My wife and I ended up seeing the 2024 eclipse just outside of Llano, TX, which I was not prepared to hear called “Lawn-o”

Federal judge unloads on ‘unserious’ RFK Jr., says anti-trans policy showed his ‘cruelty’ Judge Mustafa T. Kasubhai vacated the “Kennedy Declaration,” finding it unlawfully attempted to override medical standards and restrict care for transgender youth.

Breaking: HHS’s ban on gender-affirming care is struck down. Rarely have I read a ruling this sharply worded.

“This case is one of a long list of examples of how a leader’s wanton disregard for the rule of law causes very real harm to very real people.”

www.advocate.com/politics/nat...

A fair-skinned red-head person who has discovered he has a predisposition for melanoma only after unleashing AI agents on his genome.

If this actually happens, it may rank as the single most corrupt act in the history of American politics. I cannot believe this is even under discussion.

Derek once again equivocating on anti-amyloid antibodies as an Alzheimer's therapy:

"I do not see why these antibodies should be on the market."

"Do something else! For God's sake, do something else."

www.science.org/content/blog...

A neurosciencenews.com (real site? Who knows? I immediately wrote them off as garbage) article about a nasal spray that might reduce dementia illustrated with a profile of a nose with smoke emanating from the tip.

Pro tip to all the science publications out there: I will probably begin to think about taking you seriously when you quit using AI to illustrate - and apparently edit - your articles. No human thinks this depicts a nasal spray.

this is about as devastating sound bytes can get for both rfk jr. and trump — and on the day the cdc nomination is supposed to dominate the news cycle. rfk jr. might get in serious trouble with the white house for this one

I’m looking for an automated way to read others’s scientific data without giving credit or acknowledgement, and also claim full credit for insights from it. And I want it to have a fitting name

OAI: say no more

Looks like the Dark-Eyed Junco birds have finally left the neighborhood here in Eastern MA. They show up in the fall from Canada; this is their Florida, the little weirdos.

I've been watching every day. Tuesday they were around. Yesterday I saw only one. And today none. Au revoir until October!

I don't have access myself! But I am not optimistic. . .

A New Opioid Agonist?

The possibility of an opioid pain-relief compound with fewer side effects and lower addiction potential. Let’s hope it pans out:

This is the horrible secret sauce behind some of Trump’s public supporters, not to mention his enemies. If you turn against him, the death threats start.

It’s no way to run a country.

But you can’t always read the references it quotes, because some of those references are not even real.

Weirdly enough, I have worked with aqueous hydrofluoric acid, albeit carefully. What I won’t touch is its anhydrous gaseous form, HF. Nasty stuff!

Many egs of impt drug effects discovered by "happy accident"-but not everything! GLP-1/wt loss, despite what an otherwise good science writer says in NYT op-ed, NOT an eg. known from earliest days. I discussed in 2024 -> timmermanreport.com/2024/05/the-... @dereklowe.bsky.social @thgoetz.bsky.social

I wear the most boring clothes imaginable, TBH.

This is the tricky part for me. Even if I study up on them, the small changes you describe are not things that I’ve ever tended to notice much. I also wonder how many other people pick up on them themselves? Admittedly they’re not all as oblivious as me!

www.semafor.com/newsletter/0... (scroll down)

It’s pretty much Craig Claiborne’s, but he’s generally a reliable source. Actual Hungarians have told me it’s pretty sound.

First time I heard “Surf’s Up”, I thought yeah, Brian Wilson was indeed losing his mind. But that ending/coda hit me out of the blue and raised the hair on the back of my neck!

Just double-check stuff that’s being offered for sale. Native plants have become popular, so some places extend that category rather broadly!

www.mass.gov/info-details...

www.nativeplanttrust.org

New England Native Plants & Seeds | Blue Stem Natives Shop locally grown New England native plants, seeds, and garden goods in Massachusetts at Blue Stem Natives. Women-owned business. Supporting pollinators, birds, and healthy ecosystems.

Some possibilities:

www.bluestemnatives.com

Checking with my native plant gurus for you!

I guarantee that you have not considered this method of CNS drug delivery!

I think Vought's NIH/NSF impoundment is going to immiserate us

if I had all the money in the world, I would pepper Vought's commute into DC with billboards

RUSSELL VOUGHT LOVES CANCER

RUSSELL VOUGHT WANTS TO MAKE YOUR GRANDCHILDREN SICK

Nearly 80F here today in MA, but we have snow showers forecast on Monday. . .

Man, I sure hope this goes according to plan!

Revving Up LNP Delivery

Evidence that you can make lipid nanoparticle delivery work much better by giving the dose along with amino acid supplements. Who knew?