We are excited to welcome Dr Carlson Tsui to the Garvan Faculty.
A rising leader in cellular immunology, Dr Tsui will establish his lab within our Precision Immunology Program, focusing on unlocking the regenerative potential of the immune system.
https://ow.ly/cpiw50YAtec
Does it come with a pouch and a joey?
Only Down Under.
Pick your challenge. Go4Garvan. Power life-changing medical research.
Find out how you can Go4Garvan here: bit.ly/Go4Garvan
Ok this is next level insane! Molecular recording with minimal impact on transcript abundance and gene function!
www.science.org/doi/epdf/10....
...the Macro category left me feeling attacked...😅
If in Sydney don't miss the #free 2025 Australian Geographic Nature Photographer of the Year exhibit at the Australian Museum! The photos are breathtaking & Ross Gudgeon’s Fractal Forest inside-out macro of a soft cauliflower coral was mind blowing! Though...
@ausgeo.newsmast.social.ap.brid.gy
Yes but play it backwards.
Congrats Kelly and everyone involved! Lovely work really enjoyed reading it.
The Szilard Point is not some theoretical event horizon. It is where we are at right now. When the total cost of competing for a grant exceeds the value of available funding the system is seriously broken. We need innovative granting schemes and solutions not more of the same hunger games.
Beautiful work congrats everyone!
These 2 landmark papers came out at the start of my PhD. Science and clinic. Literally back to back. It has been an enduring inspiration ever since to be a part of this wonderful experiment called immunology.
AID's role in class switch recombination & somatic hypermutation was published in @cellpress.bsky.social 25 years ago, a tour de force combo of mouse gene discovery & mechanistic work (Honjo lab) and human genetics (Durandy, Fischer et al).
What a privilege to write this with Sidonia & Masamichi
This is next level out of this world! Disease agnostic in vivo prime editing!
www.nature.com/articles/s41...
Looking forward to this see you there Deepta!
Yea but how big was the photon? 😅
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
Nice one congrats John et al!
Out @nature.com led by @jdegregori.bsky.social Mercedes Rincon @roelvermeulen.bsky.social @jaguirreghisolab.bsky.social et al. in vivo mouse models & human data show resp. infections drive IL-6 dependent re-awakening of dormant cancer cells in lung.
So much to like about this paper! Congrats all!
Very excited at the chance to work with new people with new ideas in immunology! Really keen to hear from people from diverse backgrounds with different ways of thinking. International applicants seeking freedom to pursue BlueSky projects welcome. Come for the science. Stay for the vibe!
#immunosky
Now online in Cancer Discovery: AAnet Resolves a Continuum of Spatially-Localized Cell States to Unveil Intratumoral Heterogeneity - by Aarthi Venkat, Scott Youlten, Beatriz San Juan, Smita Krishnaswamy, Christine Chaffer, and colleagues doi.org/10.1158/2159...
Much obliged will do. 😊
😅
Yes please!
But sc data is noisy and nonlinear. AAnet takes archetype analysis to the next level by using an autoencoder to transform the data into a simplicial latent space. AAnet more accurately defines heterogeneity within cellular clusters & druggable transcriptional programs that drive heterogeneity. 3/3
Cells exist in discrete cell states (clusters) but also cells show a continuum of gene expression (trajectory). @urialonlab.bsky.social first used archetype analysis to reconcile this paradox - the bioinformatic equivalent of wave-particle duality. This works if the ambient data space is linear. 2/3
Christine Chaffer, @skummerf.bsky.social at @garvaninstitute.bsky.social, Smita Krishnaswamy at Yale et al present AAnet a neural network for nonlinear archetype analysis that more accurately captures cell plasticity & learns the spatial organisation of the archetypes. What is the advance? 1/3
Very pleased to co-write this review with Bruce Cree and Steve Hauser on the future of #multiplesclerosis treatment
onlinelibrary.wiley.com/doi/10.1002/...
It was wonderful to meet with the #OCCAMS Consortium today on #WorldMSDay for an update on our study progress, as well as reviewing recent literature on the role of EBV in multiple sclerosis. Thanks to all participants for joining in the great discussions!
@garvaninstitute.bsky.social
What have the National Institutes of Health ever done for us?