Diffusion MRI (dMRI) is a powerful tool to study white matter maturation. In our new preprint, we process and distribute a new resource of >24,000 ABCD dMRI scans using open source tools! We then evaluate how methods shape inferences about development.
🔗 www.biorxiv.org/content/10.6...
this is amazing 🤣
Incredible work by the absolutely stellar @bsevchik.bsky.social and @parkersingleton.bsky.social — the second installment of our open-science living meta-analysis of psychedelics for mental health.
And here's our second installment of sypres.io, co-led by the brilliant @bsevchik.bsky.social !!
This paper has been a long time coming. Instead of reanalyzing the same old resting-state fMRI datasets, we combined nearly all datasets around the world. Note that we didn't exactly find indisputable evidence for "default mode network disintegration."
www.nature.com/articles/s41...
Beyond delighted to see this paper -- our first from the SYPRES initiative -- now out at @natmentalhealth.nature.com. Check out Parker's awesome thread below, w/ links to dashboard + all code + data.
Excited that this is officially out there in the world. Check out the dashboard and visualizations! Huge shout out to Parker and Brooke, who led this herculean effort. More to come!
Huge shout out to co-first author @bsevchik.bsky.social, Analiese Lahey, @pimcuijpers.bsky.social, @mathiasharrer.bsky.social, @mntj21.bsky.social, Sandeep Nayak, Eric Strain, @vandyatvandy.bsky.social, Bob Dworkin, @jcobbscott.bsky.social, @ted-satterthwaite.bsky.social,
@pennlinc.bsky.social
In partnership with metapsy.org we built an interactive dashboard for exploring the data. Users can:
• Filter studies by characteristics
• Test different analysis parameters
• Test moderators
• Download figures and reports
Dashboard: metapsy.org/sypres/psilo...
Our database includes 200+ effect sizes, encompassing all depression outcomes and timepoints reported by arm in each of the 15 RCTs included. This database can be downloaded from our website (sypres.io) or imported directly into R environments using the metapsyData package.
Forrest plot of main meta-analytic model.
Here, in our first SYPRES review, psilocybin showed a greater reduction in depression scores compared to control conditions, with a pooled Hedges’ g = -0.90. But important caveats—small studies, blinding challenges, risk of bias, and design heterogeneity, which we discuss in the paper.
Screen shot of psilocybin for depression study page on sypres.io
sypres.io is our new initiative featuring:
📊 Regularly updated meta-analyses
🔍 User-guided sensitivity and moderation analysis
🕵️ Transparent study quality & risk-of-bias assessments
⚙️ Open code & data
Image of Gartner Hype Cycle
Psychedelic science has experienced the benefits and drawbacks of hype. However, new results are rarely contextualized in the historical body of evidence in an accessible manner. We need more robust, living, evidence synthesis that is visible and accessible to all stakeholders.
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out now in Nature Mental Health. Here's what we found and the open science infrastructure we built to support it 🧵
Open-Access Link: rdcu.be/fbU5V
hello
boop
What makes brains (un)conscious? We provide new answers—and a universal mammalian blueprint for information processing—in a cross-species study of humans, macaques, marmosets & mice. Exploring convergent breakdown of integration in:
www.nature.com/articles/s41...
Led by @loopyluppi.bsky.social
Happy to have been a part of yet another tour de force led by the one and only @loopyluppi.bsky.social !
The 6x US memory champion – Nelson Dellis – can memorize a deck of cards in 40 seconds and knows the first 10K digits of pi.
To figure out how, he let us peak inside his brain. Here is what we learned in our precision brain mapping study www.biorxiv.org/content/10.6...
youtube.com/shorts/MryMq...
Very happy that this paper from our lab is now out in @pnas.org! What happens when the *same* person experiences the *same* information with a *different* interpretation? Nearly the whole 🧠—well, at least nearly all association cortex—changes how it represents that information! tinyurl.com/p8chj2j7
🧠 Resting-state fMRI is often treated as the gold standard for studying the brain’s intrinsic organization.
But is it actually the best way to estimate functional architecture?
We tested this directly.
🧵1/8
We think of white matter as the highways of the brain. But when we followed development along those highways, we were surprised. The journey is more complex than we thought. My final PhD paper, “Two Axes of White Matter Development”, is now out in @natcomms.nature.com! 🛣️🧠✨
🔗 bit.ly/wm2axes
Every participant had a MEQ-30 score of 150: youtu.be/-c9-poC5HGw?...
My first preprint is out! Thank you to my brilliant collaborators & mentors for making this possible @vmarchman.bsky.social @arokem.org @jyeatman.bsky.social, as well as everyone behind the awesome open source software that we use @pennlinc.bsky.social @cieslakmatt.bsky.social (& many not on bsky)
My Neighbour Totoro is I think the only movie I can think of that has a compelling plot for kids that does not involve a villain.
hahahah
Come join an amazing team where you're guaranteed to set yourself up for future success!
💊 🍸 Risk for substance use disorder (SUD) rises in adolescence. Family history and biological sex play major roles in a person's level of SUD risk. New evidence suggests neural markers of SUD may exist before substance use starts - yet how these markers differ across sexes is not understood.
🧠I am excited to announce that our manuscript introducing a new data resource – PennLEAD (Penn Longitudinal Executive functioning in Adolescent Development) – is now available on bioRxiv. Below are some details highlighting our data resource🧵funded by NIMH R01MH113550
www.biorxiv.org/content/10.1...
