🧬 How do immune disease-relevant variants affect gene regulatory networks in CD4+ T cells?
🧪🖥️ We coupled two large-scale CRISPRi screens (>4M cells) to map the downstream cascades of thousands of SNPs
More details in the thread below 👇 or in the article 📖 on biorxiv tinyurl.com/CD4screens
Very proud to see this work out on bioRxiv. Using genome-scale TAP/Perturb-seq we mapped the function of immune-disease variants to target genes and regulatory cascades. Have a look at the 🧵from @anniquec.bsky.social for more info!
A new lab preprint is up: Work led by our MSc student Jan Sprengel comparing Interventional Causal Structure Learning Algorithms for Gene Regulatory Network Inference from single cell CRISPR perturbation screens 👇 www.biorxiv.org/content/10.6...
Take a look at the data yourself in our interactive browser www.sanger.ac.uk/tool/crispri... and read our paper for lessons learnt on the design of population- and genome scale CRISPR screens
With @leopoldparts.bsky.social and @oliverstegle.bsky.social we comprehensively mapped CRISPRi responses in iPSCs identifying protein complexes as nexus for transcriptional changes and made a first step towards population-scale CRISPR screens to dissect genetic modulation of perturbation responses
Happy to see this out now in Cell Genomics: A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines: www.cell.com/cell-genomic...
Yes, this is where you would work (the round building, not the boat)
We are looking for a postdoc to join our team! If you're interested in translating a cutting edge genomics technology (www.nature.com/articles/s41...) to real-life applications in hematology, this is for you. We offer a unique working environment ON THE BEACH: recruitment.crg.eu/content/jobs...
Auszeichnung für Heidelberger Datenwissenschaftlerin: Britta Velten wird für innovative Verfahren für die Analyse von komplexen Datensätzen aus den Lebenswissenschaften mit dem Early Excellence in Science Award ausgezeichnet www.uni-heidelberg.de/de/newsroom/...
#uniheidelberg #lifescience
Extremely honoured to receive the Bayer foundation early excellence in science award. Thanks to all my team, colleagues, collaborators and mentors for making this possible!
Was fun to be part of this!
Very nice framework to handle missing values in proteomics data by combining probabilistic factor models (alike MOFA) and suitable likelihood functions to account for values missing not at random. Take a look 👇
Do you like theoretical biology, mathematical&conceptual modelling and want to apply yourself to cutting-edge research at all levels of biology, from molecules to ecosystems?
Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Are you an AI expert who wants to stay in academia and change the world by understanding the most complex things we know - living organisms? Want to lead your own group, based in Heidelberg DE, working language English? @embl.org is hiring in AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Welcome to day 4 of #EMBOBioImage 🖥️
👉Happening right now: practical session 5, spatial statistics and omics integration, led by @brittavelten.bsky.social, assisted by Anna Klemm.
Anna Klemm presents Britta Velten (from Heidelberg University) before Practical session 5 (Spatial statistics and omics integration) in the presence of Nikolai Köhler and Wangjun Hu.
Britta Velten on stage addressing the course students.
Panoramic view of the classroom full of students attending the practical session by Britta Velten, Nikolai Köhler and Wangjun Hu.
And here we go again with Day 4️⃣ of the @embo.org course on "Advanced methods in bioimage analysis"! 🔬🖥️📊
We just started "Pratical session 5: Spatial statistics and omics integration" with @brittavelten.bsky.social and her team 💪 from @uniheidelberg.bsky.social ...
🔬 PhD Position in Bioinformatics!
Join my group at Heidelberg University (lu-group-ukhd.github.io) to study AML dormancy & therapy resistance using multi-omics & single-cell data.
👉Apply or share: www.jobvector.de/job/bioinfor...
Exciting kick-off meeting for our spatial omics seminar in and around Heidelberg organised with @tanevski.bsky.social and @denisschapiro.bsky.social. Was fun to see all the cool research happening here and connect. Reach out to us if you missed out and would like to join the next meetings!
🚀 Job opportunity: Bioinformatics Software Engineer
Join a young and passionate team at Heidelberg University to advance bioinformatics software that drive biological discovery.
Learn more & apply 👉 shorturl.at/GCpg7
Looking forward to meeting up with the spatial biology community in October! Join us in Heidelberg :-)
Do you want to advance scientific software for the life sciences? Join us now in Heidelberg as a scientific software developer. Details can be found here: shorturl.at/vqpEA
JOB OPPORTUNITY: Join us as a scientific programmer to advance tools for multi-omics data at Heidelberg University. Details can be found at shorturl.at/OcnOa and please spread the word!
CompBio method developers: software that only runs on your computer and is not available via a repository like CRAN, PyPI, Bioconductor, is not a proper research output —
just like a set of scribbled notes on your desktop is not the same as a preprint or a paper.
Finish the job.
My first post here on BlueSky to share our recent work with Claudia Feng and @leopoldparts.bsky.social - a large-scale single cell CRISPR screen to chart out gene regulation and the role of genomic background in iPSCs. Check out the data here: www.sanger.ac.uk/tool/crispri...