Torque teno virus is predictive for malignancies after kidney transplantation AbstractBackground and hypothesis. Malignancy, driven by the effects of immunosuppression, is a major complication following kidney transplantation. The wi

New publication: the Vienna group at @meduniwien.ac.at demonstrates the predictive value of #TTV load during months 4 to 12 post-transplant for the incidence of malignancy during years 2 to 5 post-transplant. academic.oup.com/ndt/advance-...

Pleased to share this study by Nabil Sweis et al. in
AJP-Renal where we report for the first time a comparison of Tolvaptan vs hypertonic saline to increase plasma sodium in normal volunteers
doi.org/10.1152/ajpr...
@feinberg.northwestern.edu @nu-nephrology.bsky.social

NephJC Short: The Push Trial — NephJC Water, water everywhere. Can a wink, a nudge and a push increase water intake to decrease kidney stone formation?

🚨 #NephJC short 🩳from @kidneyboy.bsky.social
The PUSH trial!
😉Can a wink, a nudge & a push encourage kidney stone formers to drink more fluid to prevent recurrence 🪨?
(Hint: have 💦 behavioral trials worked in CHF or PCKD?)
#NephSky #MedSky
www.nephjc.com/news/2026/4/2/nephjc-short-the-push-trial

Viren können Superheroes sein oder wie kann man das Immunsystem messen? - #LNF26 Lange Nacht der Forschung Wir erforschen wie man die Stärke des Immunsystems messen kann. Zuerst erklären wir Ihnen, anhand eines Posters und eines Animationsfilms wie das funktioniert und warum uns das TT Virus dabei hilft. D...

If you are a Vienna resident or plan a spring visit to the most liveable city in the World: come join us at our booth at the Researchers Night at @meduniwien.ac.at and learn about the superhero-virus #TTV: langenachtderforschung.at/station/6326

Function 🔙 Throw Back Thursday: Eaton at al. demonstrated that kidney-specific knockout of #Dmxl1 disrupted V1–V0 assembly, reduced proton pumping, and raised urine pH, supporting it as a mammalian #V-ATPase assembly factor. Read the full article doi.org/10.1093/func...

Proactive vs Reactive DDAVP: The Clamp Finally Faces an RCT

Thank you Thai Air Force for doing the trials that need to be done!

pbfluids.com/2026/03/proa...

Saline Doesn’t Ruin Hyponatremia Labs (It Might Help) A study by Dr. Chienwichai highlights challenges in diagnosing hyponatremia due to undisclosed intravenous saline administration. While saline infusion does not obscure urine biochemical tests, it …

Saline Doesn’t Ruin Hyponatremia Labs (and it might help)

How many times have you been evaluating a patient in the ED and bemoaned the sneaky liter of saline they got before anyone sent some urine for analysis. Turns out it doesn't ruin the labs at all.

pbfluids.com/2026/03/sali...

A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients Chronic hyponatremia is associated with adverse outcomes, including falls, neurocognitive disorders, and mortality, but whether hyponatremia itself increases morbidity and mortality, or is simply a...

The HIT (Hyponatremia Intervention Trial) is finally out!
#hyponatremia #nephrology

evidence.nejm.org/doi/10.1056/...

We advance the understanding and importance of Ca/PO4/FGF23 in Dent disease
journals.lww.com/cjasn/abstra...

This #ASNKidney360 study explored the relationship between arterial and venous blood gas parameters to develop formulas for estimating arterial values from venous samples. Read more: kidney.pub/KID1113

Thank you @asnpublications.bsky.social for posting our paper on the transformation of venous to arterial blood gas. To facilitate calculations, I developed an App “Venous to Arterial Blood Gas” available for free (apps.apple.com/us/app/venou...)
@nu-nephrology.bsky.social @feinberg.northwestern.edu

Parathyroid hormone suppression profiles following oral calcium challenge in kidney transplant recipients

doi.org/10.1016/j.kint.2025.11.019

#NephSky #MedSky #OpenAccess

-Early calcium–PTH dynamics could define PT-HPT subtypes & 🔓 personalized treatment

Potential confounders in studies identifying associations between plasma sodium correction rates and mortality. Na = sodium, AVP = arginine vasopressin A) A perceived causal relationship between an exposure and an outcome can be distorted by a third variable, known as a confounder. B) The serum sodium correction rate is the exposure, mortality is the outcome, and certain comorbidities and their severity act as confounders influencing both variables. C) Advanced stages cirrhosis, heart failure, and cancer are linked to higher mortality risk, sustained AVP release, and reduced kidney function, leading to impaired water excretion and slow serum sodium correction. D) In early stages of these conditions—or in their absence—patients exhibit better survival and, because hyponatremia is usually the result of reversible conditions with relatively preserved kidney function, serum sodium can rise rapidly through large-volume water diuresis.

Perspective by Richard H. Sterns and Helbert Rondon-Berrios:

Revisiting New Data on the Mortality Benefit of Rapid Correction of Hyponatremia: Déjà vu All Over Again

bit.ly/42Sl41K

FF 88 BICARICU-2, Bicarbonate in the ICU. Helpful or just a number fixer? Podcast Episode · Freely Filtered, a NephJC Podcast · 2025-12-27 · 1h 25m

Wow - excellent discussion of the totally underwhelming BICAR-ICU2 trial

podcasts.apple.com/ca/podcast/f...

@nephcrit.bsky.social fighting a line fight against the unimpressed nephrons with guest @weddellite.bsky.social

#NephSky #EMIMCC

Nice way to end the year being part of this paper in Cell showing that PIEZO2 is an essential regulator of renin by @rose-hill.bsky.social and top scientists including @ardemp.bskyverified.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social @nu-nephrology.bsky.social@nufeinbergmed.bsky.social

Now out @jclinicalinvest led by Christine_Behm with fantastic team of collaborators👇

We discover a corticomedullary gradient for Ca in kidney and show a critical role for claudin-2, with implications for kidney stone disease.
@kumedcenter.bsky.social

www.jci.org/articles/vie...

What to do with key cardiovascular drugs when kidney function worsens? Abstract. Patients with advanced cardiovascular kidney metabolic syndrome generally face a high risk of cardiovascular complications. Guideline-directed me

What to do with key cardiovascular drugs when kidney function worsens?

doi.org/10.1093/ckj/...

Immune Monitoring Goes Viral 🦠 Torque Teno Virus
for Immunologic Risk Stratification After Kidney Transplantation

⏩️ new review in TI 🔥

doi.org/10.3389/ti.2...
#ttvguide

The fundamental difference between water and salt water (volume) was better known at the time of Homer Smith, where they wondered how the salmon can start and end life in fresh water while spending most of life in salt water

I'm super proud of this work detailing the results of genetic testing in hundreds of kidney stone formers. We identified genetic causes for stones in 34% of those tested (47% if < 16 y.o.). So thankful for such great collaborators & patients! journals.lww.com/cjasn/fullte... #nephrology #mayoclinic

Potential confounders in studies identifying associations between plasma sodium correction rates and mortality. Na = sodium, AVP = arginine vasopressin A) A perceived causal relationship between an exposure and an outcome can be distorted by a third variable, known as a confounder. B) The serum sodium correction rate is the exposure, mortality is the outcome, and certain comorbidities and their severity act as confounders influencing both variables. C) Advanced stages cirrhosis, heart failure, and cancer are linked to higher mortality risk, sustained AVP release, and reduced kidney function, leading to impaired water excretion and slow serum sodium correction. D) In early stages of these conditions—or in their absence—patients exhibit better survival and, because hyponatremia is usually the result of reversible conditions with relatively preserved kidney function, serum sodium can rise rapidly through large-volume water diuresis.

Perspective by Richard H. Sterns and Helbert Rondon-Berrios:

Revisiting New Data on the Mortality Benefit of Rapid Correction of Hyponatremia: Déjà vu All Over Again

bit.ly/42Sl41K

Thanks to @asnpublications.bsky.social for highlighting our feature on a new syndrome of renal tubular alkalosis! www.kidneynews.org/view/journal... @nu-nephrology.bsky.social @nufeinbergmed.bsky.social

doi.org/10.1172/JCI1....
distal renal tubular alkalosis - I have been waiting for this publication for years😉

New episode of Channel Your Enthusiasm, part 2 of 3 on metabolic acidosis. Episode with chapter art, chapters, and fully referenced

www.rosebook.club/episodes/202...

ENaC expression correlates with the acute furosemide-induced K+ excretion - PubMed Acute furosemide-induced kaliuresis differs greatly and depends on the a priori molecular expression level of ENaC. Remarkably, it can be even absent in animals fed a high Na⁺ diet, despite...

....at least in animals with high potassium intake furosemide works better to induce kaliuresis
pubmed.ncbi.nlm.nih.gov/33410279/

I can't this question, but it gives me a good excuse to mention the 1970s study by Oliver et al demonstrating that high levels of renin / aldosterone alone don't drive blood pressure. It's some combination of salt+RAAS+(?). pubmed.ncbi.nlm.nih.gov/1132118/ #NephJC

Now online in @ndt-era.bsky.social

Transition of pts with hereditary nephropathies from pediatric to adult care
from WG Genes&Kidney of ERA and ESPN

🧐To improve health outcomes, pt empowerment, and engagement for young people with CKD.

▶️ academic.oup.com/ndt/article-...

Development of respiratory alkalosis and increased anion gap metabolic acidosis in salicylate poisoning.

Core Curriculum by Biff F. Palmer and Deborah J. Clegg:

Mixed Acid-Base Disturbances: Core Curriculum 2025

bit.ly/Palmer25CC (FREE)

Kidney stone disease: risk factors, pathophysiology and management - Nature Reviews Nephrology This Review discusses the pathophysiology of kidney stone formation and examines the contribution of urinary risk factors and genetic variants. The authors also consider current approaches to the mana...

Kidney stone disease: risk factors, pathophysiology and management go.nature.com/47hmWEe

@danfuster.bsky.social
@sarahhowles.bsky.social

RIP Nicolas Madias

Of the Adrogue-Madias formula and much more

I don’t know he wrote three textbooks as a medical student!

www.kidney-international.org/article/S008...
In @kidneyint.bsky.social

#NephSky