🧵 New preprint!

Whole-pancreas Gαs knockout reveals profound exocrine defects, YAP activation, and attempted β-cell regeneration from ducts in the context of severe diabetes.

GPCR atlas + PGsKO characterization.

👉 doi.org/10.64898/202...

#Gαs #Diabetes #βcells #GPCRs #pancreas

Congratulations Dr. Olszanowski @eve_olsza on the successful defense of your PhD thesis last Friday! 🎓 It was a pleasure to have co-directed you in this exciting project @ifibyne. All the best in your next steps! 👏

AlphaGenome is out in @nature.com today along with model weights! 🧬

📄 Paper: www.nature.com/articles/s41...

💻 Weights: github.com/google-deepm...

Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc

Few days left to join our ambitious and innovative program using human induced pluripotent stem cells derived hepatocytes for cell based therapies against liver diseases.

We are looking for 2 motivated, ambitious and determined technical assistants.

karriere.charite.de/stellenangeb...

Frontiers | Editorial: Advances in β-cell development & regeneration This is a provisional file, not the final article pathogenesis of diabetes mellitus is fundamentally linked to a decline in pancreatic β-31 cell mass (1). Re...

🎉 Our editorial "Advances in β-cell Development & Regeneration" is now published in @frontiersin.bsky.social! We explore restoring functional β-cell mass for diabetes therapy. Thank you to all authors.

Read & share: doi.org/10.3389/fend...

#diabetes #regenerativemedicine #betacells

Great farewell-to-2025 meeting for the lab! It was a challenging year, but we're ready for a great 2026!

Spatially organized cellular communities shape functional tissue architecture in the pancreas Spatial maps reveal dynamic epithelial-mesenchymal niches shaping pancreatic development and function.

🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social

➡️ doi.org/10.1126/scia...

short 🧵 below & more acknowledgments ⤵️

“You are here to learn to ride a bicycle, not to invent a bicycle.” 🚲🧪
Read my story in Science Magazine on how I dealt with my "Mid-PhD Crisis".
www.science.org/content/arti...

@science.org
@sciencecareers.bsky.social
#ScienceWorkingLife
#AcademicChatter
#AcademicTwitter
#ScienceTwitter

A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors - Nature Neuroscience The mechanisms linking neuropsychiatric and metabolic disorders remain unclear. The authors show a pancreas–hippocampus feedback loop whereby metabolic and circadian factors drive behavioral fluctuati...

Neurons and β-cells share many similarities, including the expression of very specific transcription factors. This prompted a long-standing search for connections between diabetes and mental disorders. This amazing discovery finally reveals a mechanistic link!
www.nature.com/articles/s41...

Can amylin-based drugs upstage GLP-1 agonists? Nature Biotechnology - Analogs of the pancreatic peptide hormone amylin are making strides in obesity as developers zoom in on oral drugs that can emulate or even improve on injectable GLP-1...

Can amylin-based drugs upstage GLP-1 agonists? They could avoid muscle loss and gastrointestinal side effects of current obesity therapies. My latest for @natbiotech.nature.com rdcu.be/ezwbM

Hoy sábado a medianoche sale nuestra entrevista en el programa "Desde el Conocimiento" por #C5N ¡Gracias a la producción del canal por la invitación para difundir nuestro trabajo en el #IFIBYNE! Transmisión online: www.c5n.com/vivo

A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics - Nature Communications Here the authors show that human pancreatic islets adapt during pregnancy with increased α-cell area and GLP-1 abundance, while key differences from islet adaptations in mouse pregnancy include unchan...

Analysis of human pancreas indicates that the molecular mechanisms driving #pregnancy induced #islet adaptations in humans differ from those in mice, highlighting the need for human-based studies @natcomms.nature.com www.nature.com/articles/s41...

💥 A single infusion into the portal vein of embryonic stem cell-derived pancreatic islet result in 12/12 patients free of severe hypoglycemic and 83% with insulin independence at one year.
However, one death due to the immunosuppressive treatment.

buff.ly/ZI14m2i

¡Gracias a la Agencia de Difusión de la Universidad Nacional de San Martin por ayudarnos con la difusión de nuestro trabajo en el #IFIBYNE, y de la difícil situación por la que está atravesando el sistema científico-tecnológico de Argentina!

www.agenciatss.com.ar/una-hormona-...

Missed our @eisg2025.bsky.social post? If you study beta cell function using rat islets or INS-1 cells, check out Ri-lnc1! Strongly linked to mature beta cells but missing from current rat genome annotations. Overlooked? Happy to collaborate—just contact us!

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

Stem cell islets for those living with T1D! www.nejm.org/doi/full/10....

Already on my way back to Argentina! Every trip must come to an end, but this one has truly been an amazing experience that will leave a lasting mark. Looking forward to consolidating the exciting new collaborations that will drive future work!

Amazing talks by @diegobalboa.bsky.social, @labspagnoli.bsky.social, Simona Chera and many other colleagues yesterday at @eisg2025.bsky.social ! I'm also really glad for the opportunity to share our recently published work. Looking forward to more exciting talks today!

Frontiers | Transcriptional signature of islet neogenesis-associated protein peptide-treated rat pancreatic islets reveals induction of novel long non-coding RNAs Background: Diabetes mellitus is characterized by chronic hyperglycemia with loss of β-cell function and mass. An attractive therapeutic approach to treat pa...

www.frontiersin.org/journals/end...

Great opening yesterday @eisg2025.bsky.social meeting! Glad to see many interesting talks using INS-1 rat cells to study β-cell function—I couldn’t help but wonder how these treatments might affect Ri-lnc1 expression, our recently reported novel rat long non-coding RNA enriched in mature β-cells 👇

Did you know that the glucocorticoid receptor fine-tunes physiological pancreas development from the earliest progenitor stages? Below, an image worth a thousand words. Want to know more? Visit us at Poster #135 @eisg2025.bsky.social today, Wednesday, at 16:55!

#TCTeAC brought more stickers for day2, find the girl with the lipstick 💄 to get yours! 😉

Thank you, Philip Allan Seymour, for the great meeting today in Copenhagen and for contributing key experiments to our follow-up work on the role of glucocorticoids in pancreas development. Looking forward to getting this continuation story out soon!

Finally! All the pieces are in place for the last stage of an amazing trip. Excited to share our results @eisg2025.bsky.social, showing that endogenous glucocorticoid receptor activation modulates early-stage cell differentiation in pancreatic progenitors of mice and humans!

It was an honor to present our most recent results on the characterization of Procr-like cells in #pancreas #development at the Shanghai Institute of Biochemistry and Cell Biology. Thank you, Dr. Yi Zeng and team, for the warm reception and the engaging perspectives!

Everything is ready for the second stage of my trip. Shanghai awaits—looking forward to interesting discussions on the characterization and role of Procr-like cells in #pancreas #development! @ifibyne @ubaglobal #DiabetesResearch

It was a pleasure discussing our latest results with Prof. Cheng-Ran Xu today at Peking University and learning more about his breakthrough advances in endocrine cell specification in mice and humans. Looking forward to a productive follow-up! #StemCells #DiabetesResearch

‘Scienticide’ in Argentina sparks huge protest by researchers Hundreds of activists wearing gas masks took to the streets to call out their government for slashing science funding.

You can say it louder, but not clearer.
"Scienticide" = the systematic eradication of any possible trace of scientific work in Argentina.

www.nature.com/articles/d41...

¡Gracias @CONICETDialoga y Bruno Geller por esta excelente nota difundiendo los principales resultados de nuestro trabajo
@ifibyne publicado recientemente en Development!

www.conicet.gov.ar/diabetes-tip...

--
Thank you @CONICETDialoga for this excellent note!

Thank you, Jorge! Your support, along with Miguel Angel's expertise with the immunos, was instrumental during the initial steps of this project. Looking forward to exploring potential follow-ups together!