ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

ER remodelling is a feature of ageing and depends on ER-phagy
www.nature.com/articles/s41...

Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice - Nature Communications Modulating the unfolded protein response (UPR) can induce protective dedifferentiation of β-cells in non-obese diabetic mice. Here, the authors show that β-cell deletion of UPR transcription factor XB...

Our new paper is out now in Nature Communications! We uncovered the function of XBP1 in beta cells of a preclinical model of T1D and identified unique and shared gene regulatory networks driven by IRE1 and XBP1.

www.nature.com/articles/s41...

Interesting study!

Grateful for the invitation to speak at Emerging Leaders in Neuroscience Seminar @weillcornell.bsky.social

My talk , “Beyond the Brain: Clues from Platelets in Alzheimer’s Pathology,” explored what platelets can tell us about AD disease progression/prognosis.
#Neuroscience #Alzheimers #platelet

Thrilled to be awarded a 3 yr @ahascience.bsky.social Transformational Project Award to investigate how platelet UPR drives functional fidelity in aging/CVD.
This takes forward my research on platelet protein aggregates in Alzheimer (AHA CDA).❤️↔️🧠
@yaleschoolofmed.bsky.social
@yalecvrc.bsky.social

#micropoetry #ekphrasticpoetry
#backtowriting

#Mantra #Mood #Musings

Congratulations! That’s definitely a cause for celebration 🎉

MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease MEK1/2 inhibitors lowered pathological αsyn in a humanized mouse model, suggesting an oral treatment strategy for Parkinson’s disease.

MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease | Science Translational Medicine www.science.org/doi/10.1126/...

We’re the heroes in our own blockbuster life movies—the genre may be action, drama, comedy or tragedy. Dont judge the music of one with the special effects of another.

Cheer for the effort, not just the award…

We’re the heroes in our own blockbuster life movies—the genre may be action, drama, comedy or tragedy. Dont judge the music of one with the special effects of another.

Cheer for the effort, not just the award…

Kudos to Kathy Martin (Chair) @yalecvrc.bsky.social , ATVB & organizers for this excellent conference bringing together the leaders & colleagues in vascular research for 2 1/2 days of invigorating scientific discussions. Also memorable were the PhD reunions!
@tarunssky.bsky.social

Honored to be a Finalist for the Brinkhous Award recognizing excellence in #Thrombosis research at #Vasculardiscovery25 & an opportunity to share our research on #platelets in #Alzheimer’s Disease.
@yaleschoolofmed.bsky.social
@ahascience.bsky.social
@yalecvrc.bsky.social

Definitely interested!

Choosing the Right Lens: Pf4 vs. Gp1b in Viewing Platelet COX-1.

An ATVB blog article where we discuss the recent ATVB study comparing Pf4-Cre & Gp1ba-Cre models, highlighting how COX-1 depletion affects thrombogenesis & atherogenesis differently.

AHA Blogs www.ahajournals.org/do/10.1161/b...

@tarunssky.bsky.social

Biomarkers of aging: functional aspects still trump molecular parameters - npj Aging Biomarkers of aging are indispensable for testing interventions. While promising, the recent focus on molecular aspects should not detract from the functional parameters for which excellent correlatio...

Interesting review!
www.nature.com/articles/s41...

These are testing times for all scientists ...Let's keep doing what we can, keeping fingers crossed ...
#Hibluesky #research #platelets

💊 Thrombocytopenia + antiplatelet therapy = a tricky balance. New study from Wolfgang Bergmeier team shows clopidogrel increases bleeding risk, while aspirin may be safer.

What does this mean for patients? Find out: www.rpthjournal.org/article/S247...

Cartoon showing mechanosensing at ER contacts with the cytoskeleton, the plasma membrane, the nucleus and mitochondria.

In their Review, @jontytownson.bsky.social and Cinzia Progida @biovitenskap.bsky.social discuss the emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction.
journals.biologists.com/jcs/article/...

In the exact same position- hope our love for science and what we do triumphs over all this….gone through all the phases of anger, denial, frustration and now resigned to just give my best shot as and when feasible…

No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis. Leslie Domínguez Cadena and Antje Blumenthal discuss new study from @lbernaleau.bsky.social et al. @@rebsamenlab.bsky.social (https://buff.ly/3ZrE70d in Insights: https://buff.ly/4gwjt5N

Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats - Biology of Sex Differences Background Alzheimer’s disease (AD) disproportionately and uniquely affects females, and these sex differences are further exacerbated by the presence of Apolipoprotein (APOE) ε4 alleles, the top gene...

New publication from my PhD research looking at influences of sex on brain health outcomes in a rodent model of Alzheimer’s disease (AD) risk 🎉: link.springer.com/article/10.1...

Big thank you to the best co-authors, @liisagalea.bsky.social, Melike Cevizci, and Stephanie Lieblich 🙏

This is an amazing work! Congratulations to the team👏🏼👏🏼👏🏼

I don’t think I have felt a month go on for so long…with one stress after another each day…just because I like studying stress responses doesn’t mean I ❤️them ! 🤷🏻‍♀️

So sorry to hear that Frederik - memories with our grandparents live in our hearts forever…

Hello from the Yale Cardiovascular Research Center! We look forward to interacting with the science community on blue sky!

For all new T&H followers, follow the starterpacks (200+ like minded ppl)🧑‍🔬👩‍⚕️🔬

Don’t know if it’s the cold or the weather (IYKYK)…could be the gradual loss of enthusiasm under the constant state of stress, deadlines and uncertainty about the future…or maybe just some internal goals which haven’t been accomplished….with no clear en in sight…
But 2025 till now has been tough…