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Posts by Ryan Gray

New preprint showing Adgrg6 and Sox9 genetically interact, increasing the penetrance and severity of scoliosis in mice and that Adgrg6-Sox9 signaling works through a self-reinforcing feedforward circuit to maintain ECM expression in connective tissues of the spine. www.biorxiv.org/content/10.6...

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I’m all in so damn good

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2026 BDPT Annual Retreat - Join us for the 22nd Lawrence Family Research Scientific Retreat & Award Competition! May 1 , 2026, 12-7:30pm (Starts at…

Alright bone aficionados! The 2026 Lawrence Family Bone Disease Program of Texas program is planned, with keynote:
Dr. Mone Zaidi.
Attendance is free, but registration is mandatory. txbonediseaseprogram.org/index.php/an...

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St. Louis folks I’ll be giving a talk 2:20pm as part of the Diane Sepich Memorial Symposium
At the Fort Neuroscience Auditorium WASHU med campus, on our work to automate the detection and quantification of cilia morphodynamics and implications on scoliosis. @wu-ciliopathygroup.bsky.social

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Protocol for quantifying vertebral column morphology for the statistical analysis of scoliosis severity in zebrafish Here, we present a protocol for quantifying zebrafish vertebral column morphology using micro-computed tomography (microCT) datasets for scoliosis researchers. We describe steps for orientation of ske...

Our newest work on quantification and statistical testing of scoliosis severity using microCT and R. www.cell.com/star-protoco... Thanks to @eceatayeter.bsky.social @brittneyvoigt

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Small molecule inhibition rescues the skeletal dysplasia phenotype of Trpv4 mutant mice - PubMed The TRPV4 skeletal dysplasias are characterized by short stature, short limbs with prominent large joints, and progressive scoliosis. They result from dominant missense mutations that activate the TRPV4 calcium permeable ion channel. As a platform to understand the mechanism of disease and to test t …

Great collaboration with Dan Cohn's group showing that small molecule inhibition of Trpv4 can rescue skeletal dysplasia of Trpv4 mutant mice.
pubmed.ncbi.nlm.nih.gov/41574606/

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20th annual @jbwallingford.bsky.social lab chili cookoff 🌶️ previlaged to be part of a few along the way. Congratulations to the top chili winner Ty Gardner!

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Our new work Cilia.io is out on the Rxiv. Ece Atayeter and Jason Ho trained an ML computer vision transformer for detection and quantification of cilia morphology and dynamics. We will provide a GUI soon. Another great collaboration w/ @jbwallingford.bsky.social

4 months ago 12 1 0 2
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Congratulations to the newly minted Dr. Brittney Voigt! After defending a fantastic thesis spanning work in my lab and the @edwardmarcotte.bsky.social lab.

5 months ago 22 3 2 1
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An a reserve O-4 so even less weight to throw…something, something about hats and cattle.

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The most important element of nucleotide polymer synthesis is a 3’-OH.

6 months ago 1 0 0 0

Greatest hotel eh-va!

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It’s fish sauce all the way down.

7 months ago 1 0 0 0

That real purdee

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As Vice Chair of the GRC Bones and Teeth, I am delighted to invite you to join us for our upcoming meeting, on January 25–30, 2026, at Hotel Galvez in Galveston, TX, a cherished venue for our conference.
We look forward to welcoming you to what is sure to be an exciting and memorable meeting!

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Mr Kevin ‘shiny ribs’ Russell at Wyldwood

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New music Friday. @leifvollebekk.bsky.social is incredible. Highly recommend. Can’t wait to see you in the ATX in November.

7 months ago 2 0 0 0
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Skeet a PERFECT Album from the 90's that isn't Nirvana or Pearl Jam. I wore this goddamn album out.

7 months ago 1 0 0 0
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Fun times with friends

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Beautiful.

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If you offer coffee and cookies he doesn’t throw them as hard. #themoreyouknow

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Slightly diminish a band: the Meh Dead

8 months ago 0 0 0 0

Slightly diminish a band: U1

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No more like ice cube …

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Today was a good day…

8 months ago 4 0 1 0

Cool new paper on the role of cilia in postnatal pituitary development.

9 months ago 4 0 0 0
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EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis - PubMed Idiopathic scoliosis (IS) is the most common form of spinal deformity with unclear pathogenesis. In this study, we first reanalyzed the loci associated with IS, drawing upon previous studies. Subseque...

Great new paper showing that human AIS may be in part modeled as a sub-clinical neuromuscular disorder.
pubmed.ncbi.nlm.nih.gov/40662934/

9 months ago 1 0 0 0

It’s like I always say the best Beatles album is “Exile on Main Street”

9 months ago 3 1 1 0
Interlibrary loan: Borrowing | UVA Library

Use your interlibrary loan service library.virginia.edu/services/ils.... I use mine all the time. The more you know!

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