Thrilled to present our comparative study on the evolution of zygotic genome activation (ZGA)!! 🥚🧬

Amazing PhD work of @campobes.bsky.social together with @fedemantica.bsky.social and many collaborators! @melisupf.bsky.social @crg.eu. Thread below 1/15

www.biorxiv.org/content/10.6...

An information-theoretic argument for the restriction of the current biological alphabets to 4 nucleotides and 20 amino acids - Scientific Reports Life as we know it is based on foldable biopolymers encoded with just 4 nucleotides or 20 amino acids. Evolution of these biopolymers requires effective and fast search of both the conformational spac...

Why are there 20 amino acids and 4 nucleotides?

Combining Energy Landscape and Molecular Information theories provides constraints to the alphabet size of an evolving biopolymer, given its physico-chemical properties...

Read more in our new article:
www.nature.com/articles/s41...

Exon inclusion signatures enable accurate estimation of splicing factor activity - Nature Communications Splicing factors shape how genes are stitched into RNA, but their activity is hard to measure. Here, the authors benchmark network methods and show exon-inclusion signatures infer splicing factor acti...

Many regulatory layers modulate splicing factors at the same time impacting their activity.

How can we quantify it? Apparently "functional" target exons give us a hint and uncover two cancer programs.

Have a look at our solution: www.nature.com/articles/s41...

Transcription start sites experience a high influx of heritable variants fueled by early development - Nature Communications The impact of transcription on germline mutagenesis remains poorly understood. Here, the authors identify a mutational hotspot at transcription start sites in the human germline that is significantly ...

I am very pleased to see our work, in which we describe a mutational hotspot at transcription start sites in the human germline, out:
www.nature.com/articles/s41...
Great work from @castellanoed.bsky.social, @vseplyarskiy.bsky.social, Miguel Cortés Guzmán and Clàudia Serrano Colomé!

Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.

More info: www.crg.eu/en/content/t...

🧬 New review on nanopore basecalling models is out! ✨
Congrats to @soniacruciani.bsky.social (former Novoa Lab PhD, now postdoc at the Deplancke Lab, EPFL) and @evamarianovoa.bsky.social👏
📖 www.nature.com/articles/s41...

Three major trends in comparative transcriptomics

🧬🧬🧬 New review from the lab:

Evolution of comparative transcriptomics: biological scales, phylogenetic spans, and modeling frameworks

authors.elsevier.com/sd/article/S...

By @mattezambon.bsky.social & @fedemantica.bsky.social, together with @jonnyfrazer.bsky.social & Mafalda Dias.

Great time with friends and colleagues in our annual retreat of the Di Croce lab north of Barcelona #CRG

Would like to be in : )