KLF2 is a critical regulator of thymic epithelial cells homeostasis and preventor of autoimmunity
www.sciencedirect.com/science/arti... @cp-iscience.bsky.social

Your Thymus and Your Healthspan New landmark studies using AI to determine thymus health and its link to major outcomes

Your Thymus and Your Healthspan
erictopol.substack.com/p/your-thymu...
Plus: can we rejuvenate our thymus?

Thymus health is a predictor of lifelong well-being and immunotherapy effectiveness It was thought that the thymus serves its purpose for the immune system early in life. Insights about the organ in adults reveal its importance for later well-being.

Wow. Multiple papers showing clinical relevance of thymus function for lifelong health and immunotherapy outcomes. Like music to my ears! www.nature.com/articles/d41...

www.nature.com/articles/s41...

www.nature.com/articles/s41...

www.nature.com/articles/s41...

Extremely proud of our publication in @natcomms.nature.com.
We report a genetic system based on synthetic Notch receptors (Yin&Yang) that we engineered to record and identify cell-to-cell interactions in vivo in the thymus.
Collaboration @mirjana-efremova.bsky.social

Wow. Beautiful if devastating data vis of biomedical research funding in the US right now.

Happy birthday to one of my favourite haters, Charles Darwin

Review @natimmunol.nature.com
The development of innate lymphoid cells
www.nature.com/articles/s41...

@biorxivpreprint.bsky.social immgenT: A Comprehensive Reference of Convergent T-cell States in the Mouse
www.biorxiv.org/content/10.6...

@biorxivpreprint.bsky.social The αβTCR repertoire at scale in the immgenT dataset
www.biorxiv.org/content/10.6...

@biorxivpreprint.bsky.social immgenT Treg: A Reference Landscape of Regulatory T Cell States in Mice
www.biorxiv.org/content/10.6...

Very happy to share our new study defining the ontogeny of Thetis cells and the developmental cues that shape their early-life wave of differentiation. www.nature.com/articles/s41... Beautiful work led by @hhmi-science.bsky.social Gilliam Fellow Yoselin Paucar Iza and postdoc Tyler Park 1/

Brilliant mentorship AND memeship!

Fibroblastic reticular cells direct the initiation of T cell responses via CD44 - Nature CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune r...

Fantastic new paper from @the-de-lab.bsky.social showing how the CMV m11 protein drives immune evasion by blocking CD44-dependent, FRC-mediated DC migration in the spleen, ultimately dampening antiviral CD8⁺ T cell priming @monashuniversity.bsky.social www.nature.com/articles/s41...

Excited to share this work done in collaboration between @mklevings.bsky.social lab and @jonesr18.bsky.social from Peter Zandstra’s lab, on making human CD4 T cells from pluripotent stem cells!

Březina et al. @czechacademy.bsky.social show that #Claudin 1 enables thymic type 1 #DendriticCells to localize in close proximity to medullary thymic epithelial cells, supporting the maturation & tolerogenic function of type 1 dendritic cells rupress.org/jem/article/...

#Tolerance #Autoimmunity

Claudin 1 enables thymic type 1 dendritic cells to localize within proximity to MTECs to prevent disruptions in T-cell tolerance @jem.org @czechacademy.bsky.social
rupress.org/jem/article/...

Transient hepatic reconstitution of trophic factors enhances aged immunity - Nature Using lipid nanoparticle delivery of mRNAs to the liver in aged mice, T cell function and declining immune cues can be restored.

Nature research paper: Transient hepatic reconstitution of trophic factors enhances aged immunity

go.nature.com/4pD0f3H

Unintended consequences of upending global trade. Who would have thought?!

One proposed strategy to promote a youthful immune system and human healthspan is to rejuvenate our thymus gland. Can we learn from this exceptional (and peculiar looking) vertebrate that can do this?
science.org/doi/10.1126/...

The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine A quiet policy change means the government is making fewer bets on long-term science.

In the past decade, the U.S. National Institutes of Health awarded top scientists $9 billion in competitive grants each year, to find cures for diseases and improve public health. Starting in January, the Trump administration will stall that funding.

Fred Hutch's Immunotherapy Integrated Research Center is recruiting an Open Rank Faculty position to lead a laboratory-based program focused on tumor immunology and cancer immunotherapy with a strong vision/path toward clinical translation.

Learn more: https://apply.interfolio.com/176403

We are hiring! We have a postdoc position opened @fredhutch.org to join our team to design next gen cellular therapies for cancer. Heavy focus on T cell signaling and understanding how synthetic receptors instruct T cells to fight cancer.

@natrevimmunol.nature.com Guidelines for T cell nomenclature
www.nature.com/articles/s41...

Intrathymic progenitor cell transplantation restores T cell development through ILC3-TEC crosstalk www.biorxiv.org/content/10.1101/2025.11....

T cell fate is dictated by different antigen presenting cells in response to dietary versus gut epithelial self-antigen www.biorxiv.org/content/10.1101/2025.11....

A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides The T cell receptor (TCR) orchestrates immune responses by binding to foreign peptides presented at the cell surface in the context of major histocomp…

I have been silent on this issue in hand -well here it is #TCR and #crossreactivity A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides. www.sciencedirect.com/science/arti...

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.

Want to get a tough sample, like lung, looking like this? Read more!

www.biorxiv.org/content/10.1...

Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells @jem.org
rupress.org/jem/article-...

A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice Nature Immunology - Grimes and colleagues integrate multiomic features to create a framework that allows the isolation of discrete cell states across hematopoiesis and exploit the underlying gene...

New “discrete state” model of hematopoiesis published in Nature Immunology. rdcu.be/eL8oO
We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.

Coming out of retirement for just one last epic score.