Come together: The BE-TILs—Efficient multiplex base editing of tumor-infiltrating lymphocytes The safe translation of multiplex gene-edited tumor-infiltrating lymphocytes (TILs) into an effective clinical product is like crossing a busy street: tumor excision, TIL isolation, precise gene editi...

🚨Commentary alert!🎵“Come together, right now…” As The Beatles sang: we comment on an approach to Base Editing of tumor-infiltrating lymphocytes (TILs)-the BE-TILs!😉Strategy with hit potential? www.cell.com/molecular-th... ..the earworm: rb.gy/20pxyz @moltherapy.bsky.social @dlwagnerlabs.bsky.social

Review @frontiersin.bsky.social @bextetobias.bsky.social
Engineering with care: safety assessment platforms for CRISPR-modified NK cells
www.frontiersin.org/journals/imm...

Frontiers | Engineering with care: safety assessment platforms for CRISPR-modified natural killer cells CRISPR-based gene editing has become a transformative tool to enhance immune cell therapies. In particular, engineering natural killer (NK) cells with CRISPR...

🚨Paper alert! Happy to share our review on safety assessments for gene-edited #NKcells. A highly timely topic for future multiplex-edited NK cells!
Proud of my first senior authorship together with safety-tool expert Toni Cathomen. Congratulations to Alieh for fantastic work! tinyurl.com/4b4f6383

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

@dlwagnerlabs.bsky.social on tour! 🌍🇩🇪🇺🇸

We had a great time at the Annual Congress of the European Society for Gene and Cell Therapy #ESGCT2025 in Sevilla. 🇪🇸

Super proud of everyone who presented their projects & grateful for working with this amazing team: science and good vibes! 🧬🧪💙

Next-generation multiplex-edited CAR-NK cells: more edits, more power? First clinical trials demonstrated the safety of adoptive cell transfer with allogeneic natural killer (NK) cell products from healthy donors, making them an attractive candidate for ‘off-the-shelf’ c...

🚨 Paper alert!
"Next-gen multiplex-edited CAR-NK cells: more edits, more power?" @jitc @bmj.com
With @dlwagner.bsky.social we discuss Wang et al.’s landmark paper on multiplex base-edited non-viral CAR-NK cells. Promising efficiency but safety challenges! jitc.bmj.com/content/13/9...

Precision targeting of rhabdomyosarcoma by combining primary CAR NK cells and radiotherapy Background: Rhabdomyosarcoma (RMS) is the most common type of soft-tissue sarcoma in children, and it remains a challenging cancer with poor outcomes in high-risk and metastatic patients. This study r...

🥳 #PaperAlert 🚨
Huge congrats to my lab-bestie Lisa Marie Reindl!! 💪🎉 So proud of you!😎🌟
EGFR-tarheting CAR NKcells in combination with radiotherapy showed significant tumor reduction ex vivo and in vivo in hard-to-treat solid tumors of rhabdomyosarcoma!
jitc.bmj.com/content/13/7... @bmj.com