Canada Lives Because…

Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism - Nature Metabolism By developing a method that allows detection of transient, low-abundance acyl-CoA species, Liu et al. provide a thorough characterization of coenzyme A dynamics and subcellular partitioning.

RESEARCH | R Liu, H Shen et al. (Yale):

A new method enables a thorough characterization of coenzyme A dynamics and subcellular partitioning. 🧪

Excited to share our work just published in @natmetabolism.nature.com examining melanoma tumor metabolism in patients and how well this is (and isn’t) conserved in patient-derived xenograft models.

Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression Epithelial serous borderline tumors (SBT) are non-invasive neoplastic ovarian lesions that may recur as chemo-resistant low-grade serous cancer (LGSC)…

Proud to share our latest work in ‪#CancerCell‬ in collaboration with the @mannlab.bsky.social: we map the progression from borderline ovarian tumors to low-grade serous ovarian cancer and propose a promising new therapeutic strategy.
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www.sciencedirect.com/science/arti...

Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells | Molecular Systems Biology imageimagePathway-focused metabolite ratio-based analysis of 49 tumor and 8 normal epithelial cell lines grown in their respective standard conditions reveals common and distinctive metabolic signatur...

Incredibly proud of our latest publication in @molsystbiol.org led by @nancyts.bsky.social in collab w/ Jean Yang and Lake-Ee Quek - www.embopress.org/doi/full/10....
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.

FUR AND INTERFERENCE AND MISINFORMATION

1/My 7th grader's science homework is to learn the elements Memorize atomic masses. She points out that carbon has a mass of 12. My life passes before my eyes. Finally, my chance to explain what I've been doing for 20 yrs. So I say, kind of casually, "you know, sometimes carbon has a mass of 13..."

Pioneering Changes in Patient Advocacy with Kimberly Richardson

Thankful for the opportunity to speak with @shikhajainmd.bsky.social about my patient advocacy journey. Listen here - www.healio.com/news/hematol...

9/Thanks to @rjdlab.bsky.social for all of his support, guidance, and patience over the years.

And finally, to all the patients who joined our study and donated tissue- Thank you. We hope this work accelerates further discoveries in NSCLC

8/A special thanks to Dr. Kemp Kernstine, without him none of this work would have been possible.

In my lab, I'm fortunate to have a fun, hardworking, collaborative team. A special thanks to @niahammond.bsky.social, who has spearheaded all of our metabolic and metastatic mouse work

7/ In my opinion, this project has been a fantastic example of team science, and I'm grateful to have worked with so many great collaborators, clinicians, surgeons, pathologists

6/We found that inhibiting complex I in the mitochondria was able to reduce metastatic dissemination in these models.

We still need to figure out the contexts in which TCA and ETC are needed in supporting metastasis, and how this may change in specific organ environments.

5/A limitation to studying metabolism directly in patients? It’s hard to test hypotheses.

So, we generated patient derived xenografts (PDXs)

These PDXs proved invaluable. They have similar metabolic properties to the patient tumor AND they spontaneously metastasize in NSG mice.

4/This labeling pattern spans across other tumor features like histology and mutation. To borrow a phrase from Ralph and Matt, we think it’s a ‘convergent’ metabolic property.

Metabolite abundance alone did not predict survival. I think this underscores the value of using stable isotopes

3/In this study, we found that most tumors had extensive 13C enrichment in TCA cycle metabolites.

Patients whose tumors had high 13C TCA cycle enrichment had worse survival outcomes than those with less enrichment.

2/ We use intra-operative infusions of 13C-labeled nutrients, like glucose, to study tumors

We’ve learned a lot with this approach. We saw that tumor metabolism can be very heterogeneous and that tumors use a variety of nutrients. Even so-called “waste” products are recycled by lung tumors.

1/For over a decade, we’ve been studying tumor metabolism in patients with non-small cell lung cancer

This long-term commitment allowed us to connect tumor metabolic features to patient outcomes

We found that 13C glucose contribution to the TCA cycle predicts overall survival in NSCLC

I’m really proud to announce the 2025 Cancer Metabolism Showcase and Workshop, May 5th and 6th, 9:30 AM - 3 PM EST. This year, our Keynote Speaker is Dr. Jeffrey Rathmell from VUMC.

I'm excited to come together, talk science, and support researchers in our field.

www.cancermetabolismshowcase.org

Faubert honored at Winter Classic for cancer research | NHL.com University of Chicago professor receives V Scholar Award for work on lung cancer

My lab and I were ecstatic to be funded by the VFoundation and Astrazeneca.

Learning it was also sponsored by Hockey Fights Cancer was extra special to my Canadian, hockey-obsessed self.

Experiencing the Winter Classic? A dream come true.

www.nhl.com/news/univers...

WHAT THE LIBERAL PARTY WISHES THEY COULD SAY
- PART ONE

Quietly renames “interesting papers to read in 2024” folder to “interesting papers to read in 2025” folder

"Nerd-vana". A week of non-stop discussions about isotope tracing with expert faculty and enthusiastic trainees in Nashville.

Come for the 13C-glucose infusions, stay for the mechanical bull ride.