Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇

Delighted to share the latest preprint from the lab led by Janith Seneviratne

We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)

www.biorxiv.org/content/10.1...

Embryonic stem cell factors DPPA2/4 facilitate a unique chromatin state in non-small cell lung cancer Embryonic regulators are often re-expressed in cancers, however the functional and molecular significance of this is not always understood. The epigenetic priming factors Developmental Pluripotency As...

Read the paper here! www.biorxiv.org/content/10.1...

Congrats to Janith and the rest of the lab @petermaccc.bsky.social, and thanks to collaborators Shabih Shakeel @wehi-research.bsky.social, @benparkerlab.bsky.social and @burrlab.bsky.social, and ongoing support from @snowmedical.bsky.social
(6/6)

Congrats Mel and team!