Parliamentlive.tv Science, Innovation and Technology Committee

Some thoughts on the select committee appearance by the boss of UKRI, Ian Chapman yesterday. It’s a long watch but can be seen here: parliamentlive.tv/Event/Index/...
Thread 🧵

Bought this record solely off the back of this post. Just finished playing it and as written in the liner notes, it is achingly beautiful. Great record and great label.

Setd1a Loss-of-function Disrupts Epigenetic Regulation of Ribosomal Genes via Altered DNA Methylation AbstractBackground and Hypothesis. SETD1A, a histone methyltransferase, is implicated in schizophrenia through rare loss-of-function mutations. While SETD1

New paper in @oxfordacademic.bsky.social Schizophrenia Bulletin exploring the effects of Setd1a happloinsufficiency on DNA methylation in the frontal cortex. Strong effects on the regulation of ribosomal genes with implications for understanding the genetics of schizophrenia. doi.org/10.1093/schb...

Really excited, exhausted and relieved to finally be able to share the results from an analysis of the @GenomicsEngland 100,000 Genomes Project dataset.

Here's a link to free access to the manuscript:
authors.elsevier.com/a/1l8iU3vlFV...

see below 🧵for main outcomes

Mojo bar is a cracking blues joint 🤘

Analysis of exome sequencing data implicates rare coding variants in STAG1 and ZNF136 in schizophrenia Rare coding variants across many genes contribute to schizophrenia liability, but they have only been implicated in 12 genes at exome-wide levels of significance. To increase power for gene discovery,...

New preprint from the group! New exome seq data and novel rare variant associations. Led by the brilliant Sophie Chick www.medrxiv.org/content/10.1...