Summary of main findings. Left: Main contributions of the somatosensory inputs to the generation of motor activity in M1. Cortical state generation is independent from somatosensory inputs. Right: Schematic Vm modulations of an M1 neuron in an intact mouse (IT Vm) and in a nerve cut mouse (NC Vm) during a Quiet to Movement transition. The removal of forelimb inputs did not impact the occurrence of quiet/active periods in the membrane potential, but (1, vertical line) reduced pre-movement input; (2, gray box) reduced Vm correlations with ongoing forelimb movement; and (3, horizontal line) disrupted the reach reversal potential.
How does somatosensory input to the #MotorCortex contribute to limb movement? This study shows that loss of #somatosensory inputs disrupts voluntary forelimb movements & motor cortex neuronal dynamics, highlighting the role of somatosensory input in motor control @plosbiology.org 🧪 plos.io/3QcbXph
