Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations.
www.nature.com/articles/s41...
My former bench mate @joellemiere.bsky.social from the @fredchanglab.bsky.social giving a killer talk about nuclear size regulation in fission yeast at #ASCB #CellBio2025
Stay tuned for the paper to come soon !
Beautiful experimental data falling on the mathematical model, no fit needed 🤩
Too fluid, too rigid, no patterning. Garner et al. identify tissue fluidity—how freely cells move within a tissue—as a critical regulator of adhesion-based cell sorting. Read their study to learn how tissues can tune their fluidity to enable patterning.
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj
Our work on Naegleria Myosin 2 is out!
Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.
Read more: www.cell.com/current-biol...
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
Magliozzi, Goode and colleagues @brandeisuniversity.bsky.social report that fungal proteins form a 'composite' #actin nucleator and pointed end capper. rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry
PhD or Master's position available for Fall 2026!
Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!
Allocation of resources among multiple daughter cells. New study from Alison Wirshing, Daniel Lew and colleagues @mit.edu: rupress.org/jcb/article/...
#Cytoskeleton #Development
📢📢Hiring 2 Research Assistants & 2 Postdocs at Emory University in Atlanta to study cytoskeletal biophysics/biochemistry. Please RT.
RAs: great for recent bachelor's/master's in Physics/Bio/Chem/Biochem. Email CV and interests to shekhar@emory.edu.
More info: www.shekharlab.org
The multinucleate, multibudding yeast, A. pullulans delivers nuclei into each daughter bud during #mitosis. Petrucco, @gladfelterlab.bsky.social, Lew et al image #microtubules during mitosis, revealing mechanisms ensuring that most daughters inherit one & only one nucleus rupress.org/jcb/article/...
What could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells?
www.biorxiv.org/content/10.1...
Video by Vittorio Boscaro.
1/n
Lawmakers to NIH: Use it or lose it.
14 Republican Senators—including key appropriators—are urging the White House to release NIH FY25 funds without delay, warning that stalled spending could harm future research budgets.
Read more: www.ascb.org/science-poli...
My fabulous colleague (and ex-postdoc) @inechipurenko.bsky.social and I (mostly Inna!) wrote a review extolling the many virtues of C. elegans for the study of cilia biology. A really interactive and collaborative community of people working in this field too.
www.sciencedirect.com/science/arti...
1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬
www.science.org/doi/full/10....
Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage www.biorxiv.org/content/10.1101/2025.05....
Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhavdhar.bsky.social in collaboration with Sudarshan and Deepak Nair. www.biorxiv.org/content/10.1...
In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...
Our PhD student Louis Romette is optimizing long-term live-cell imaging. He just casually dropped this 65-hour movie of a growing neuron (div 3 to 6) with knocked-in actin 🔥🕶️ #realtimemicroscopy
I’m excited and honored to be giving a talk at The New England Society for Microscopy Spring Symposium! Thanks for the invitation, @andystoneimaging.bsky.social
How is mitochondrial volume maintained across successive generations of dividing cells? In our new preprint, we show how fission yeast cells use mitochondrial activity to control division timing and maintain mitochondrial homeostasis! (1/n)
📖 www.biorxiv.org/content/10.1...
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
📢Excited to share our new paper in Nature Physics
@naturephysics.bsky.social: Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular Stentor!
How do single-celled organisms benefit from teamwork? Let’s dive in! #Multicellularity nature.com/articles/s41...?
Alex Long, the last postdoc from my lab at Stanford, is starting her own lab, continuing her beautiful work on evolutionary cell biology using chytrid fungi as a model. Check it out! alonglab.org
Many of these grants are fellowships and training grants supporting smart young people interested in bettering the world through their research. It is sad to see NIH funding used as an indiscriminate tool of retribution.
I have confirmation from several sources now that all T32s, many F30s and F31s, and most or all Center awards (P30, P50) have been terminated at Columbia.
This is quite damaging to research and to individuals.
This is pure terrorism and cannot be legal. But litigation will take time...
The Das lab is hiring! We are looking for a postdoctoral associate interested in investigating the fundamentals of cell polarization. Prior yeast experience not needed.
bc.csod.com/ux/ats/caree...
We propose a model where the new flagellum grows in a linear manner while the old one is locked but shrinks slightly, hence requiring unlocking and compensation after cell division, leading to such multicoloured flagella following induction/deinduction/reinduction of tagged tubulin 😉
A flyer for the MBL's 2025 Physiology course
🔔Upcoming deadline!🔔
January 27 is the last day to submit applications to the MBL's 2025 Physiology Course. This seven-week lab course has educated generations of leading biologists and fostered groundbreaking discoveries.
Learn more: bit.ly/3BZSj9c
#ScienceStartsHere
