Decatur is awesome. I always tell prospective students that Atlanta / Decatur is a fantastic place to be a broke grad student / postdoc

Nitrogen, Ammonia, and the Strait of Hormuz

Chemistry in current events: the connections between fertilizer, the Haber-Bosch process, and the Persian Gulf. Read this and your knowledge will exceed that of most of our current political leadership after only a few minutes of light work:

which brand of prescription safety goggles did you get? I’ve heard good things about stoggles but don’t NEED a new pair quite yet.

Solution to job rejection blues. Onward and upward! :)

yeah I figured, bummed I cant make it this year, looks like a blast.

Check out antico’s pizza! Should be ~10 min from the venue.

Woahhh I’m (sorta) on a paper with Scott Bagley!

P.s. I’m sure you’ll be plenty busy with ACS, but if you somehow end up around Emory can we take a pic with my heptanes bottle for #TeamHeptanes

I also love that they emphasized Kyle’s favorite word: —Cryptic— (coined by Brad Moore)

I know I literally just saw this!!! I literally did the like cartoon *spits drink, wipes glasses, eyes pop out of the socket* emote whe I saw it!

Made Sophia Kyle and I’s day :)

Just curious, do you buy this or make it with the prep im seeing in org lett (🐐 journal)

This is a really cool transformation, congrats to all involved. Can say from firsthand experience that a lot of those existing 2-H indazole synthesis don’t work as well as advertised (at least in my hands…)

this is such a awesome transformation, congrats to everyone! Kyle and I are real interested in a few of these products in particular 😎

no worries! this one has been haunting me for a bit. thanks for sharing it!

might have missed it but did you post a solution for this one?

Chicago: if you’re around the southside, the point is a beautiful park around the lake. Also Strings is an amazing ramen place in Chinatown - very easily accessible from the train

Lots more on this project that I cant share quite yet, but special thanks to the Sieber lab at TUM for hosting me in Munich to learn and perform these chemoproteomic experiments! Lipoprotein trafficking is clearly an attractive target for gram(-)’s, especially for beta-lactamase expressing bacteria.

We then demonstrated that OXA-23, the beta-lactamase that confers resistance, is itself an outer-membrane lipoprotein. Inhibiting lipoprotein trafficking via LolF thus also causes over-accumulation of OXA-23 to the inner membrane, which exaggerates these inhibitor’s antibiotic properties.

To understand this unique effect, we used a photoaffinity probe of this HTS hit to assign the Lol complex as the protein target of this compound! Resistance selection, Lol overexpression, and CRISPR studies also confirm lipoprotein trafficking as the major MOA.

Also, an awesome collaborative paper I worked on during my PhD is now published in PNAS!

www.pnas.org/doi/10.1073/...

Our collaborators discovered a small molecule that is a BETTER antibiotic against beta-lactam resistant bacteria than beta-lactam sensitive ones. We wanted to understand why.

ATL Roller Derby Pride match! Highly recommend checking out if there’s a team near you :)

nice turnout in ATL!

Free Drug Concepts: A Lingering Problem in Drug Discovery

J Med Chem is on 🔥 with the editorials lately, and I highly recommend giving this one a read. Understanding free drug principles is the gateway to all of pharmacology, and is all too often mangled and misapplied by drug discovery practitioners.

literally just had to do this for all my procedures for an SI… add this to the list of things AI could probably do that would be useful 🥲

A polyene macrolide targeting phospholipids in the fungal cell membrane - Nature Mandimycin, a polyene macrolide, exhibits strong antifungal activity and possesses a mode of action that is distinct from other compounds of this class.

Nature research paper: A polyene macrolide targeting phospholipids in the fungal cell membrane ttps://www.nature.com/articles/s41586-025-08678-9

never used it, but always thought the Beckmann rearrangement was a neat and weird one

Clonal Candida auris and ESKAPE pathogens on the skin of residents of nursing homes - Nature Analyses of strain-resolved metagenomics with isolate sequencing data of skin samples from residents at nursing homes suggest that skin is a reservoir for Candida auris and other multidrug-resistant bacterial species.

Nature research paper: Clonal Candida auris and ESKAPE pathogens on the skin of residents of nursing homes

https://go.nature.com/4igrfC1

The Cation−π Interaction in Chemistry and Biology The cation−π interaction is an important noncovalent binding force that impacts all areas of chemistry and biology. Extensive computational and gas phase experimental studies have established the pote...

Dougherty (Chem Rev 2025 ASAP) The Cation−π Interaction in Chemistry and Biology (currently free to read) #PhysChem #CompChem #cheminformatics #chemsky 🧪
doi.org/10.1021/acs....

Thanks Dr. Rouhier! Hope all is well back on the hill :)

My PhD Defense is tomorrow!! If you’re interested in hearing about some soon-to-be published work on the discovery and synthesis of new gram-negative antibiotic compounds with a unique mechanism of action, DM for a zoom link!

tbh I’m trying to be both at the same time

yikes same, didn’t realize this…