🚨📰Now online in its full form www.nature.com/articles/s41...

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability The ER's continuous tubular network is maintained by ER-shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of ...

🚨📜Our new paper out in @AdvSciNews:
ER shape matters for neuronal health - disrupting ER continuity halts neuro-firing as it slows Ca2+ store refill, explaining selective neuronal vulnerability to ER problems in neurodegeneration 🧠
a thread to follow advanced.onlinelibrary.wiley.com/doi/10.1002/...

Pre-print Alert! Naked mole-rats hold secrets to healthy ageing that may be revealed if we can dissect their cellular mechanisms. Led by Fangze Tong (an amazing MPhil student), we report live-cell findings about NMR autophagy.
@phar.cam.ac.uk @psalmotoxin.bsky.social

biorxiv.org/content/10.6...

Go Lily! Huge congrats - massively deserved!

Postdoctoral Research Assistant - MCDB - UOD2016 Closing date: Thursday 6 November 2025, 23:59

Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.

www.dundee.ac.uk/work-for-us/...

Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome Dravet syndrome (DS) is a severe childhood epilepsy caused by mutations of the sodium channel NaV1.1. These mutations are thought to compromise the ability of inhibitory interneurons to regulate netwo...

I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩
www.biorxiv.org/content/10.1...

Such elegant work, as ever!

Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!!

Make my day and check it out!
www.biorxiv.org/content/10.1...

#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬

Endogenous gene editing of alveolar organoids reveals that expression of pathogenic variant SFTPC-I73T disrupts endosomal function, epithelial polarity and wound healing Background: Idiopathic pulmonary fibrosis is a fatal lung disease of progressive lung parenchymal scarring caused by the aberrant response of an alveolar epithelium repeatedly exposed to injury. Under...

New preprint alert! Endogenous gene editing of alveolar organoids to investigate mechanisms of epithelial dysfunction in familial ILD. Kudos first author @eimearrutherford.bsky.social and thanks @thecimr.bsky.social @labrawlins.bsky.social @profmarciniak.bsky.social
www.biorxiv.org/content/10.1...

Thrilled to collaborate with @zhixingchen2.bsky.social Lab @pku1898.bsky.social !
We tested new PK Mem dyes—gentle, photostable tools to label the plasma membrane in live neurons, making it easier to track growth cone motility & axonal transport. #liveimaging #neuroscience
tiny.cc/3qhp001

Great opportunity!

Fantastic stuff by Sam and team!
3D tracking of individual proteins inside intracellular compartments. An amazing innovation towards understanding cellular environments.

Deep Visual Proteomics maps proteotoxicity in a genetic liver disease - Nature High-resolution spatial proteomics were used to map molecular events during hepatocyte stress in pseudotime across all fibrosis stages, recapitulating known disease progression markers and revealing e...

Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution.
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...

#newPI and time is running.

It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab:

warwick.ac.uk/fac/sci/med/...

Well done Jessy @jessyzhu-jiayi.bsky.social who gave her #biologists100 flash talk today about her new GCN2 activators

@biologists.bsky.social
@thecimr.bsky.social

Fantastic Skytorial!

Congratulations @lily-wu.bsky.social for winning a poster prize at the @biologists.bsky.social #biologists100 conference! What a superstar!
@thecimr.bsky.social @profmarciniak.bsky.social @matthoare20.bsky.social

Great to see this published! Congrats on a really beautiful paper!

I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday

The 16th ER & Redox club meeting ends. THANK YOU to co-organiser @fenech-lab.bsky.social & to everyone for outstanding presentations, discussions, posters and fun over the last 4 days in Namur. Huge thanks to @unamur.bsky.social @biologists.bsky.social @febspress.bsky.social for support and funding!

Fantastic conference! Thanks so much to you and @fenech-lab.bsky.social for bringing us all together! What a great community.

Special congratulations to the first and second authors, Natalia Brzozowska and Lily Wu!

Thanks to The MRC @ukri.org, CRUK, @wellcometrust.bsky.social, and @alpha1foundation.bsky.social for funding

Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...

Delighted to share our latest paper on alpha-1-antitrypsin deficiency, in @naturegenet.bsky.social.

A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell.

@thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute

We present:

Direct-view oblique plane microscopy

www.biorxiv.org/content/10.1...

Amazing Conference Alert!!
Registration is now open for EUROSERPIN2025. Come and join us in beautiful Brescia, Italy, this May to get excited about the wonderful world of serpin proteins!
Visit euroserpin.eu to sign up. Early-bird rates offered until February 28th.

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease | The EMBO Journal imageimageDisorders of surfactant protein biology cause dysfunction of alveolar type 2 cells and can lead to interstitial lung disease. This study describes the development of genetically manipulable, mature human fetal-derived alveolar type 2 ...

Great to see this collaborative effort out! Check out our new alveolar organoid model, ripe for studying disease mechanisms including those involving surfactant proteins:

www.embopress.org/doi/full/10....

Front cover image to follow soon!

@eimearrutherford.bsky.social @profmarciniak.bsky.social

Thanks!

Great list. I would love to join, if there's still space please!

We have a postdoc opportunity at the interface of metabolism and epigenetics! 🔥🧬

The project will investigate novel metabolic factors driving diabetic cardiomyopathy🫀, and test targeted dietary interventions 🍽️

For more detail and to apply:
babrahaminstitute.livevacancies.co.uk#/job/details...

‼️Deadline 16th January 2025‼️Applications are open for the 2025 Experience Postgrad Life Sciences programme. Paid 8-week summer internships aimed to enhance diversity among life scientists of the future!! @cambridgebiosci.bsky.social @corpuscambridge.bsky.social www.exppg.lifesci.cam.ac.uk