Exciting opportunity: we are hiring a postdoctoral fellow for a fully funded 2-year position!

Amazing view from the 24th floor of the Sorbonne tower at the 7th German-French DNA Repair Meeting! Excited to give my talk tomorrow!

open access version here: hal.science/hal-05250217

New paper out! We show that RecBC remodels single-stranded DNA gaps to protect them from ExoI (sbcB) 3′-5′ exonuclease degradation during replication of damaged DNA.

doi.org/10.1073/pnas...

#RésultatScientifique 🔎 Découvrez la dernière publication de Vincent Pagès et de ses collaborateurs !

🤝 @cnrs-dr12.bsky.social @insermpacacorse.bsky.social @univ-amu.fr @paoli-calmettes.bsky.social @pageslab.bsky.social @crcm.bsky.social

👉 @narjournal.bsky.social
buff.ly/rVeGV9B

Thanks Annabel!

Our key findings:
-DNA polymerase η swiftly bypasses UV-induced lesions at the replication fork.
-Post-replicative gaps allow Translesion Synthesis (TLS) to compete with Damage Avoidance (DA), reducing mutagenicity.
-Gap extension by Exo1 nuclease favors DA and reduces TLS

Our latest article, in collaboration with Helle Ulrich, explores how the timing of lesion bypass and gap processing impacts genome stability.
doi.org/10.1093/nar/...

How does Pol IV overcome strong replication blocks in E. coli? Our latest study with @joeloparo.bsky.social uncovers a bipartite clamp interaction that helps Pol IV compete with Pol III, enabling efficient TLS at stalled forks and reducing mutagenesis.
https://buff.ly/3Xbgjxd

Recruiting a postdoc to work on our yeast project