Excited to share our J Med Chem paper led by talented postdoc Stephan👨‍🔬 ! 🔗 pubs.acs.org/doi/10.1021/... We show that sugar-derived carbobicyclic nucleoside analogues are a promising chemotype for antiviral drug discovery 💊Many thanks to all collaborators for their important contributions!

@pubs.acs.org @acsbiol.bsky.social @cuhk-gcni.bsky.social

Proud PI moment: my 2 PhD students are featured @ ACS Chem Biol! lnkd.in/gEW7WDWu
👉New chemically induced proximity tools to dissect O-GlcNAcylation 🍬
1. Covalent, lysine-targeting OGTAC: lnkd.in/g4sqcUZP
2. OGTAC that degrades POI: lnkd.in/gEJQJVBa

Functional analysis of O-GlcNAcylation by networking of OGT interactors and substrates - Nature Chemical Biology Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activiti...

Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activities and tissue-specific functions #glycotime

www.nature.com/articles/s41...

Ligand-Directed Self-Assembling Chimeras for Targeted Protein O-GlcNAcylation Precise control of protein-specific O-GlcNAcylation in cells remains a major challenge. Chemically induced proximity (CIP) offers a promising path forward, but its application to targeted protein O-Gl...

Excited to share our 2nd-gen OGTAC🎯: we turned a potent inhibitor into a non-inhibitory covalent binder, enabling targeted O-GlcNAcylation🍬Congrats to the OGTAC team @CUHK, esp. PhD student Zhihao! also thanks to collaborators at Kyoto Univ. & HKU! Link: pubs.acs.org/doi/10.1021/...

Activation and regulation of cGAS-STING signaling in cancer cells Cancer-intrinsic genomic instability drives cytosolic DNA accumulation, triggering cGAS-STING immune signaling. Shim et al. review recent advances in cancer/cGAS-STING crosstalk, with a molecular-level focus on sources of cytosolic DNA and immunoregulatory mechanisms, including their therapeutic implications.

Activation and regulation of cGAS-STING signaling in cancer cells

@carolynbertozzi.bskyverified.social @stanford-chemh.bsky.social @stanford.edu

@acs.org @pku1898.bsky.social @cuhk-gcni.bsky.social @cuhkmedicine.bsky.social

Great to present our work on chemically induced proximity for modulating glycosylation at the ACS Publications Symposium! 🧪⚗️Inspiring to share the stage with giants such as Profs. Carolyn Bertozzi and Chris Chang😃 Big thanks to Ng Lab @CUHK for driving this!

I got tenure and promotion to Asso. Prof. at CUHK!😃Deeply grateful to my incredible team and collaborators for their dedication and support!💡If you're passionate about drugging the undruggable with chemical-induced proximity tools💊, reach out to us: ngwailung.com

[NEW paper!] Proximity-induced O-GlcNAcylation: we showed that a single sugar modification can act as a molecular switch that triggers protein degradation & more!🍬Huge congrats to the OGTAC team!👏Open-Access Article: pubs.acs.org/doi/10.1021/...