🧵 Our new paper is out today in molecularcell.bsky.social! After 7 years of a truly intriguing discovery journey, we can finally share what controls how molecules move inside living E. coli cells. Spoiler: it's not what the field thought. A thread 👇
📄 doi.org/10.1016/j.molcel.2026.03.018
I just uploaded a video walkthrough of the tutorial I recorded this morning.
youtu.be/C4LYZokS_t4
📢 📢 📢 !!!Come and join us!! 📢 📢 📢
We are looking for a Postdoctoral Researcher with in-depth experience in next- and third-generation sequencing to help us understand the fitness landscapes of complex biomolecules! Please spread the word :)
werkenbij.rug.nl/vacature/pos...
omg omg, huge congrats!!!
Always assumed Michaelis & Menten were two guys; turns out Menten was a badass woman and is my new academic crush! Wikipedia: “She played the clarinet, created paintings worthy of art exhibitions, climbed mountains, went on an Arctic expedition, enjoyed astronomy, […] had mastered several languages”
Beautiful picture looking out of the chemistry building at the University of Freiburg in Freiburg Germany. The old cathedral can be seen in the distance with a backdrop of a blue sky with clouds and distant foothills of the black forrest with fall colors showing through in the trees
picture of the Münster at dawn in the Altstadt of Freiburg, Germany, with a still dark sky in the background and moon over the Münster, in the foreground a well-lit flowers stand can be seen preparing for the daily morning market
I have a PhD position available in my lab at the University of Freiburg!! If you, or someone you know, might be looking for a position using modeling and simulations to uncover secrets in (glyco-)protein structure/function relationships please take a look at our website!
www.kearnslab.org
Figure 3 from the paper with the caption: "Role of machine learning in de novo design of IDRs. (A) Machine-learning models can be trained on diverse data sources, from molecular dynamics simulations to annotations of cellular localization and protein structures from the Protein Data Bank. (B) Often implemented as neural networks using sequence-encoded features as input, these models can initially be trained on a limited region of sequence space as surrogate models. Through active learning, additional simulations are performed during the design campaign to generate new data, and the surrogate model is retrained on the expanded dataset to progressively improve its accuracy. (C) Machine-learning models have been developed to predict biophysical observables, biological annotations, and protein structures. When combined, machine-learning models can be used to identify a set of sequences that strike a trade-off between multiple design objectives, defining a Pareto front."
New review on computational design of intrinsically disordered proteins 🖥️🍝 by @giuliotesei.bsky.social @fpesce.bsky.social & 👴
doi.org/10.48550/arX...
🔬 Looking for a postdoc or scientist position in the Netherlands!
My passion: proteins, especially enzymes, antibodies, and protein engineering.
Hands-on experience in biochemistry & molecular biology.
Open to exciting opportunities! DMs open 📩
#JobSearch #ProteinEngineering #Postdoc #Biotech
excellent work by using ApbE! Well done @wahyuwidodo.bsky.social
4. Still, we try to express these people with 3 pages of words (CV) because we need a job. And tbh these things are extensively pushing me to stay in academia.
2. They ask for managing experience, but do they know how hard to manage bachelor students in the lab? And this doesn't count as managing skills. 3. A person who knows nothing about science can not judge us just by looking at our CV. Because most of the time this is the case.
Now that I am finishing my PhD and looking for a 'real' job (because apparently academia doesn't count as experience), let me complain about HR people. 1. In what world PhD doesn't count as experience? You work 8 hours in the lab, with 'real' projects and people. Sometimes even more than 8 hours...
Check this wonderful new review from our lab on flavin transferases! 🧬✨ Magic behind new covalent attachment and -ofc- flavin fixing. Great job Xiaoman!
www.sciencedirect.com/science/arti...
Happy to be part of this paper👩🏻🔬
🔬 New research by @michielslab.bsky.social @liselotdewachter.bsky.social @vibmicrobes.bsky.social in @naturecomms.bsky.social shows how protein 'clumps' drive bacteria into a state of dormancy, with implications for antibiotic resistance. ➡️ Read here vibbio.tech/40Qxc2M
🙌 FWO Vlaanderen - KU Leuven