Mesmerizing light sheet imaging of neutrophils swarming at a yeast target!
The neutrophils were labeled with SPY650-DNA (yellow) and a calcium dye (blue).

This movie is part of the recent manuscript by @strickland-evelyn.bsky.social that we highly recommend reading!

www.biorxiv.org/content/10.6...

These fuckin chuds

Naming your biology LLM after Rosalind Franklin is… hell is not hot enough

IN THIS ECONOMY???

Our latest publication grapples with how the brain could implement gradient descent by sending learning targets top-down, gating plasticity with dendritic inhibition, and updating synaptic weights with biologically observed learning rules like BTSP.

www.cell.com/cell-reports...

I love this photo of astronaut Christina Koch looking back at Earth from Artemis II.

She's the first woman to see the full sphere of our beautiful planet.

Welcome home to the crew, and thank you for reminding us of all we can discover together.

A transcriptomic microglia taxonomy across mouse and human pathologies - Nature Immunology In this atlas paper, the authors provide a transcriptomic and spatial taxonomy of myeloid cells in the central nervous system of mice and humans in health and pathology.

www.nature.com/articles/s41...

New giant paper from our lab. Here we present:

>>A transcriptomic microglia taxonomy across mouse and human pathologies.<<

Congrats again to Chintan and Marco, and aaaall authors, collaborateurs and friends from around the world.

#microgliaAfficionado

Laser scanning on your equipment entails tradeoffs between speed, resolution, and field-of-view. Pick 2 of those 3.

Now you can get all 3, with this breakthrough.

www.laserfocusworld.com/optics/artic... Thanks @laserfocusworld.bsky.social

GWAS does, in fact, sometimes work, contrary to my deepest held beliefs

🚨🚨🚨JOB ALERT🚨🚨🚨

The Image Analysis Unit at Human Technopole in Milan is recruiting for two positions to join our growing team:

1) Bioimage Analyst
2) Research Software Engineer (RSE)

Read on to learn why one of these two people should be you!

this is so painful to read, i love it github.com/stephenturne...

“Copy Moon joy” #Artemis

Massive wildfires followed oceanic anoxic events during the Late Devonian Frasnian-Famennian mass extinction Wildfire was a consequence — not a cause — of widespread marine anoxia during the Late Devonian mass extinction.

Massive wildfires followed oceanic anoxic events during the Late Devonian Frasnian-Famennian mass extinction | Science Advances www.science.org/doi/10.1126/...

It has come to my attention that not all of you are aware that this exists. So, here it is. It exists. Dozens of channels of randomized music videos and bumpers. Choose your era and return to your childhood. Bookmark it for when you need to escape back.

wantmymtv.vercel.app/player.html

NASA just dropped this image of Artemis II astronaut Christina Koch looking back at us. The first woman to ever see our planet in its entirety. I’m not crying you’re crying 🥹🔭🧪 📸: NASA

a photo of the earth taken from the Artemis mission in space. you can see the traceries of clouds along with the auroras on both poles. the continent of Africa is visible along with the atlantic ocean

look at that you son of a bitch

thats all we have. thats it. that's all there is, this impossibly delicate little egg in the endless black nothing. this water droplet. its our home, its where we all live and hating each other just makes no sense when its this precarious

www.biorxiv.org/content/10.6... Odon, a rust based ome zarr viewer! Seems fast, even if limited to 2D at the moment, goes on the to try list :))

‘Why is publishing so expensive?’ For many of us who work in scientific publishing, the title of this Editorial is a question we hear all the time when we're out talking to academics. And it's a perfectly reasonable one. After all, re...

A question I get asked all the time by @dev-journal.bsky.social authors "Why does it cost so much to publish a paper?"

We break down the finances and explain where the money goes

Spoiler: quality publishing takes a village (people + infrastructure)

journals.biologists.com/dev/article/...

New preprint: our lab’s first Alzheimer’s paper! “Loss of neuronal population organization links pathology to behavior in a model of Alzheimer's disease”
www.biorxiv.org/content/10.6... 🧪🧵1/

MuViT: Multi-Resolution Vision Transformers for Learning Across Scales in Microscopy Modern microscopy routinely produces gigapixel images that contain structures across multiple spatial scales, from fine cellular morphology to broader tissue organization. Many analysis tasks require ...

Very good looking sparse segmentation in this one! arxiv.org/abs/2602.24222 I just wonder if all 12 transformer layers are necessary, for those of us with 3D data and no H100 GPUs

Genetically altered chimeric antigen receptor astrocytes targeting amyloid-β reduce a cardinal pathological feature of Alzheimer’s disease @science.org @washumedicine.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

A cochlea imaged in light-sheet microscopy (right) with staining for spiral ganglion neurons (red) and inner hair cells (blue). You will develop AI-based methods to analyze these structures, for example via segmentation of the individual cells (right) that will support gene therapy development for hearing loss and a better overall understanding of the anatomy of hearing.

Looking for a PhD position at the intersection of AI, imaging, and gene therapy? Apply for this position in my lab: tinyurl.com/2a2v6tvx

Part of sfb1690.uni-goettingen.de to study hearing, vision, and more.

Plus, you can create pretty pictures as the one below :).

🧪🦣🏺 I'm quoted here, and much of what I spoke about with Carl echoes April's comments.
Extra thoughts:
1. nice new piece for extending complexity in how we think about #Neanderthal interactions, though as authors note, multiple mechanisms (not just mate choice) possibly active in X chromo patterns

Intelligent Imaging Innovations - Microscopist Intelligent Imaging Innovations

3i is hiring a Microscopist - repost & tell a friend!
Ideal candidate has experience in fundamental optical theory & familiarity with lightsheet, spinning disk, multiphoton, TIRF etc. Full-time, exempt position (travel to visit customers) offering a competitive salary & comprehensive benefits.

Our latest preprint, led by @lizihegarty.bsky.social & aided by @erinwatson.bsky.social shows that fixation time matters when it comes to visualising #macrophages in #salivarygland & other epithelia.We find 1hr allows detection of mac subsets while preserving architecture. With @bainlab.bsky.social

Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualisation in epithelial tissues www.biorxiv.org/content/10.64898/2026.02...

iconic shot of Lucas Pinheiro Braathen on the podium

no, it simply isnt.
People are talking about capital using gAI as an excuse to conduct mass lay-offs, about students losing learning because theyre being lied to about gAI in education, about the mass theft of the work of artists and authors to train LLMs, about CSAM and nonconsensual sexual images.

How did life arise from simple chemical building blocks?

New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.

Read more: mrclmb.ac.uk/news-events/...

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.

www.science.org/doi/10.1126/...

elodieunderglass I can confirm that most birds have a detectable amount of wiring behind the eyes - blinking lights and buttons and sliders and frizzy things that spark and chirp and beep. They also have a lot of soul that can communicate with ours because the programming is fairly compatible. Vultures are clever and curious, swans are clear and lawful, chickens have a lot of personality, caged parrots are dissociated and disinherited and frankly worrying, falconry-trained birds of prey are tremendously businesslike. And owls are absolutely lovely beasts with their own irreplaceable validity. but they are basically stuffed with polyester fiberfill. They have one button, like a child’s toy dinosaur that opens and closes its mouth when you press the back of its head. And it isn’t even a sophisticated electronic button it’s just a lever that rocks back and forth to make the claws open and close. I think they may have actually evolved independently from sponges. Their skulls simply exist to create holes that funnel sound and light, and as a place to hang a giant hinged beak. An owl is just an empty tube like a windchime that the wind whistles through, and you can drop meat down it. They use the meat to generate feathers, and then emit the bones in pressed little packages like those machines that flatten a penny and stamp it with the logo of a theme park. I think that’s the gist of it - most birds are electronics of varying levels of sophistication, but owls are just a system of levers and pulleys. No elevator music in those skulls, just the wind echoing through empty caverns of slightly irritating design. Absolutely fantastic.

finally found this tumblr post expounding on how stupid owls are piraticoctopus.tumblr.com/post/6741867...