Our work highlights FMg's power to unravel new #AntibioticResistance mechanisms and to get essential phenotypic data for better surveillance #OneHealth.
Huge thanks to all collaborators on the #SEARCHER (formerly #EMBARK) project and the @iame-umr1137.bsky.social team! 3/3

These genes include known and unknown beta-lactamases, and a partial penicillin-binding protein encoding gene, all newly linked to cefiderocol resistance.
Notably, some genes are broadly distributed across all wastewater samples analyzed in our study. 2/3

Our pre-print on #Cefiderocol resistance genes found in the environment is available! www.biorxiv.org/content/10.1...
Using functional metagenomics (FMg), which identifies novel resistance mechanisms, 4 genes were found increasing MIC for this last resort antibiotic.
Check our study design: 1/3