📣 New CLARITY articles by Erin McCreary, PharmD & Ahmad Mourad are out to help us understand the GAMECHANGER trial & #cefiderocol The first notes a mortality signal among metallo-β-lactamase–producing infections... #IDSky #clinmicro https://ow.ly/GAqx50Yq6uh
Second paper from MRes (!!) student Caitlin Duggan; #AMR mechanisms and the challenges of actually measuring and defining what is "resistant", deep dive into #cefiderocol susceptibility testing & resistance mutations
#MicroSky #IDSky 💻🧬 #MicrobiomeSky
www.biorxiv.org/content/10.6...
Our study in #AccessMicrobiology reports the first Irish surveillance of #Cefiderocol vs P. aeruginosa in #CysticFibrosis 💊⚔️🦠 85% of isolates were susceptible, including MDR, XDR, PDR & mucoid phenotypes - highlighting its potential as a salvage option 🛡️🌍 #MicroSky #IDSky
🔗 doi.org/10.1099/acmi...
Our pre-print on #Cefiderocol resistance genes found in the environment is available! www.biorxiv.org/content/10.1...
Using functional metagenomics (FMg), which identifies novel resistance mechanisms, 4 genes were found increasing MIC for this last resort antibiotic.
Check our study design: 1/3
Great interactions of my PhD students with experts in the AMR field about their work! #ESCMIDGlobal #AMR #RIVM #surveillance #cefiderocol #plasmids
JOIN the posters; Nation-wide spread of an outbreak-associated IncFIB-multidrug-resistance plasmid, the Netherlands, 2018-2022", and: "CefiderocolFinder: a pipeline to detect genetic adaptations implicated in cefiderocol resistance #ESCMIDGlobal #plasmids #Cefiderocol #RIVM
Juan Antonio del Castillo nos presenta su estudio de comparación difusión x discos / microdilucion para la determinación de sensibilidad a #Cefiderocol en K. pneumoniae.
Concluye que la difusión x discos podría SOBREESTIMAR la resistencia a cefiderocol.
#25CongresoSEIMC
All you need to know about #Cefiderocol in 10 tweets. BRA VO!
x.com/MayoClinicINFD…
@EASLedu @EASLnews #cefiderocol is an experimental cephalosporin which may be the answer for carbapenem resistant enterobacteriacae (a. Baumanii, p. Aeruginosa) #IlC2019
