I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

Cortical regulation of collective social dynamics during environmental challenge - Nature Neuroscience Raam, Li, Gu and colleagues identify neural mechanisms underlying group huddling in mice during cold exposure. They find that the prefrontal cortex encodes decisions to huddle and that silencing neura...

Excited to share my postdoc work is out in @natneuro.nature.com today!

We examined how the brain enables social groups to collectively coordinate their behavior in the face of environmental challenge ❄️🐭🐭🐭🐭❄️ :

www.nature.com/articles/s41...

Roth Lab Welcome! We study the synaptic and circuit bases for motor control and motor learning. The brain’s ability to learn and form new memories relies on the precise reorganization of neuronal circuits, inv...

Very excited to share that I’m starting my lab at the Krembil Brain Institute @kbi-uhn.bsky.social at UHN and the University of Toronto!

If you’re interested in motor learning and circuit plasticity, please reach out - we are hiring!

www.motor-plasticity.org

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Xin Lab Welcome! We study the cellular interactions between neurons and oligodendrocytes, which produce myelin in the central nervous system. Myelination - the process by which oligodendrocytes ensheath neuro...

Super stoked to share that I’m starting my lab at UHN @dkjei-uhn.bsky.social / @kbi-uhn.bsky.social and the University of Toronto!

If you’re interested in neuron-myelin interactions in circuit maturation and cognition, please reach out - we are hiring!

www.oligodendrocyte.org

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Astrocytes enable amygdala neural representations supporting memory - Nature Astrocytes in the basolateral amygdala dynamically track fear state and support fear memory retrieval and extinction.

Really nice work from the Holmes lab looking at amygdala astrocytes in fear memory and extinction!

www.nature.com/articles/s41...

Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX

Welcome to SFN !!! @julielefebvrelab.bsky.social and I will be hosting the "Bridging the Synapse" networking event on Monday 11/17 at the Marriott at 7 PM! Come hang out with synaptic biologists from all over to talk about the coolest topics in neuroscience with the coolest folk! Spread the word!

I was once called a gliavangelist and it holds true nearly a decade later. Can you blame me?

Astrocytes functionally integrate multiple synapses via specialized leaflet domains Volumetric high-resolution electron microscopy reveals thin astrocyte leaflets form gap-junction-interconnected domains that contain minuscule endoplasmic reticulum saccules and enwrap synapses in clu...

Astrocytes functionally integrate multiple synapses via specialized leaflet domains

Glycopolymers stabilize protein folding and protein-protein interactions via enthalpic interactions Macromolecular crowding is ubiquitous to physiological environments, perturbing the thermodynamics and kinetics of proteins via excluded volume and nonspecific chemical interactions. While crowding ha...

Thrilled to share this manuscript from my lab where we looked at how glycopolymers that compose the glycocalyx influence protein folding and protein-protein interactions via macromolecular crowding.

TLDR: The Glycocalyx stabilizes protein folding and PPIs

www.biorxiv.org/content/10.1...

Congrats, Uri!

Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind - Nature Neuroscience Differences in neuroeconomic decision-making influence nucleus accumbens dopamine dynamics and reflect choice confidence during evaluation, as well as past and future value during re-evaluation, which...

Dopamine dynamics in the nucleus accumbens core reflected decision confidence during evaluation of decisions in an economic foraging task in mice, as well as both past and future value during re-evaluation and change-of-mind

@perothwell.bsky.social

www.nature.com/articles/s41...

A divergent astrocytic response to stress alters activity patterns via distinct mechanisms in male and female mice - Nature Communications Early-life stress has lifelong impacts on neuronal function and behavior. Here, the authors show that astrocytic glucocorticoid receptor signaling drives stress-induced neuronal and behavioral change ...

Absolutely thrilled to share the first half of my PhD work! Super proud to see it finally out!
www.nature.com/articles/s41...

Thread below for a quick (10 point) recap of what we found!
🧵🧪🧠

Systems consolidation reorganizes hippocampal engram circuitry Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.

rdcu.be/el18q

A short thread follows for those interested.

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Inflammasome signaling in astrocytes modulates hippocampal plasticity The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social
All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

Congrats!!!

Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out!
gleichmanlab.com

Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.

Really cool and important work with interferon at the podium composing a glial symphony (alongside a visiting lymphocyte ensemble) geared towards repair!

This paper changed my life: Shane Liddelow on two papers that upended astrocyte research A game-changing cell culture method developed in Ben Barres’ lab completely transformed the way we study astrocytes and helped me build a career studying their reactive substates.

In our latest edition of “This paper changed my life,” @liddelowsa.bsky.social explains how two papers from Ben Barres’ lab completely changed the way the field studies astrocytes and enabled everything discovered in glia research since.

#neuroskyence

www.thetransmitter.org/this-paper-c...

Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasti...

Our new paper is out in Science.

What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.

Congrats Jake!

www.science.org/doi/10.1126/...

Multi-omic analysis reveals the unique glycan landscape of the blood-brain barrier glycocalyx The blood-brain barrier (BBB) glycocalyx is the dense layer of glycans and glycoconjugates that coats the luminal surface of the central nervous system (CNS) vasculature. Despite being the first point...

🚨 A new Daneman Lab preprint!! 🚨

Reid Larsen, one of the brightest scientists I know, studied the BBB glycocalyx, identified its structure, composition, and function and uncovered what makes the CNS glycocalyx unique. It was a true pleasure to be a part of this seminal study!
shorturl.at/Wkhxr

A neuroimmune circuit mediates cancer cachexia-associated apathy Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres...

1/ Why do patients with late-stage cancer lose motivation & sink into apathy?
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...

Refreshing to see @moeneuro.bsky.social deliver a home-run on empathy and compassion in a time that needs more of it.

🚨iGluSnFR4 is finally out!🚨🧪

We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️

www.biorxiv.org/content/10.1...

🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX

#Neuroscience

Aging activates escape of the silent X chromosome in the female mouse hippocampus Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.

this exciting work comes from studying sex differences - reactivation of the silent X chromosome in aging female mice reveals factors that promote cognition in old XX and XY mice. super cool, congrats to all - lets keep studying what makes us different!
www.science.org/doi/10.1126/...

Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 - Nature Neuroscience The authors show that brain inflammation in COVID-19 correlates with viral load, systemic inflammation and virus-sensing pattern recognition receptors. Microglial dysfunction occurs at sites of vascul...

Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 @natureneuro.bsky.social
www.nature.com/articles/s41...

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates Hasel et al. show that molecularly and morphologically specialized astrocytes make up the brain and spinal cord surface, thereby creating the glia limitans superficialis. These astrocytes selectively ...

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates: Cell Reports www.cell.com/cell-reports...

LET’S DO THIS UCSD

#standupforscienceUCSD

Talked for 1+ hour with my Trump-supporting grandma and succeeded in convincing her to call her AL representatives to protect a strong American investment in science and to end the chaos. Have these difficult conversations, provide detail, and you will be surprised of their power.