Genome-wide genealogies reveal deep admixtures forming modern humans www.biorxiv.org/content/10.64898/2026.04...

Benchmarking of shotgun sequencing depth reveals the potential and limitations of shallow metagenomics and strain-level analysis - Nature Microbiology A comparison of sequencing of complex mock communities performed at multiple depths and analysed using different methods establishes minimum standards that can ensure the accuracy of metagenomic analy...

Benchmarking of shotgun sequencing depth reveals the potential and limitations of shallow metagenomics and strain-level analysis www.nature.com/articles/s41... #jcampubs

DNAharvester's workflow.

We present DNAharvester 🎉🦴🚜🧬

A pipeline to process highly degraded ancient DNA data that integrates metagenomic filtering, competitive mapping, multiple alignment strategies, reference bias evaluation and much more.

GitHub: github.com/NBISweden/DN...

Preprint: www.biorxiv.org/content/10.6...

Y’all I don’t even know what to say or do. 😭 What a nightmare.

Votes are powerful and consequential.

a dumpster with the word chicago on it is floating in the water ALT: a dumpster with the word chicago on it is floating in the water

Lab flooded at 4 am. How is your Monday going? 😿

Our review on adaptive introgression in the context of climate adaptation is now published in Mol Ecol:
onlinelibrary.wiley.com/doi/10.1111/...

In a nutshell: often invoked theoretically, rarely unambiguously demonstrated empirically!

Many thanks to everyone who shared feedback on earlier versions

One last Disneyland trip on a beautiful day in sunny California! Living in SoCal has its benefits 🏰

Update - he be back from long read whole genome sequencing! Can't wait to dig in!

And while you're there check out our latest paper led by Erik Funk, "Historical and contemporary genomes of an endangered rodent reveal shifts in environmentally associated genes"! @arynwilder.bsky.social

LAVA: a method for identifying local and global adaptation in structured populations www.biorxiv.org/content/10.64898/2026.04...

Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...

@hhmi-science.bsky.social's
#FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits

Stable, sustained support can transform your career:

Senior Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA

Ancient DNA reveals pervasive directional selection across West Eurasia - Nature Analysis of 15,836 ancient West Eurasian genomes reveals hundreds of instances of directional selection, showing that sustained changes in allele frequency were widespread, rather than being...

Incredibly impressive ancient genome analysis by Akbari et al. in Nature, also looks at selection against psychiatric traits. Amazing science, I personally still struggle with strong selection against smoking in eurasia before Tabaco got to Europe, absolutely amazing data/work though!

Not the prettiest of preps, but the best I could muster at 8 pm after a brutal day. Happy Tamil New Year (Parabava Varusham) to all my fellow Tamils. And my payasam was absolutely divine!

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Any of you sneak a run or two on the head node while the HPC admin isn't watching? 😜

a painting of uncle sam pointing at the viewer with an american flag behind him ALT: a painting of uncle sam pointing at the viewer with an american flag behind him

It's looking increasingly likely that I'll be hiring a 3-year computational pop-gen postdoc/PhD-level scientific programmer to start this Fall (2026). If you or someone you know is defending soon, and looking for a position, please DM/write to me! Thanks!

Spread the word! UChicago BSD is currently searching for an instructional professor (open rank) to help develop and support graduate training in quantitative biology at UChicago. This is an Instructional Professor position (open rank). apply.interfolio.com/183517.

Congratulations, Gina!!! How exciting!!!

Hands-down one of the best lectures I’ve attended in a while. Thank you, @bielleogy.bsky.social for being such an amazing researcher and student advocate!

Aahh! Blanding's turtles are SO photogenic (also with a perpetual smile) <3 Great shot!

❤️❤️❤️❤️❤️

a cartoon of spongebob saying put it in the bag . ALT: a cartoon of spongebob saying put it in the bag .

Umm got ‘selected’ to get early tix for the 2028 LA Olympics, and they run no less than $5000 for horrendous seats at the welcome/closing ceremonies, and no less than $200 for qualifier games. Dafuq kinda robbery is this?!

Estimating the evolutionary fitness of specific synonymous codon changes www.biorxiv.org/content/10.64898/2026.03...

Computing coalescence rates for complex demographies and sampling configurations www.biorxiv.org/content/10.64898/2026.04...

The Genomic Legacy of the Norman Conquest in Rural England www.biorxiv.org/content/10.64898/2026.04...

a cartoon drawing of a spaceship being released by parachutes ALT: a cartoon drawing of a spaceship being released by parachutes

Unabashedly squealed and jumped at the splashdown when I was at the gym - turns out I had company with all the brawny straight guys.

a blue truck is parked in front of a building with the letter r visible ALT: a blue truck is parked in front of a building with the letter r visible

Thought it was a sonic boom from Artemis II! Nope - just our garbage van making the rounds. Gonna be a long few hours here in San Diego!

Whoa—machine learning strikes again (in a good way)

www.pnas.org/doi/10.1073/...

📣New Review!
📄Integrating genetic data with biological insight: A practical guide to cis-Mendelian randomization
🧑‍🤝‍🧑 @vkarhune.bsky.social @stevesphd.bsky.social & co
👉 bit.ly/4tKkY7r

Genetic predictors of GLP1 receptor agonist weight loss and side effects - Nature Identification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision medicine approaches in the treatment of obesity.

Nature research paper: Genetic predictors of GLP1 receptor agonist weight loss and side effects

go.nature.com/4ttoMJY