The Tribeca Film Festival slate was just released and it's absolutely STACKED this year ... so much for being financially responsible this month :p

lol my take that #TheDrama is wildly romantic is going to go over as well as when I argued The Shape of Water was the most beautiful love story of 2017

I really don’t understand how the MTA has no effective systems in place so that minor issues like someone needing help on a train doesn’t snarl rush hour trains for hours … genuinely why are we so much worse at this than everyone else

The audible gasp I gave when Ryan Gosling puts two tubes next to each other in the centrifuge in Project Hail Mary lol

Hollywood studios!! I’m available as a science consultant!! I’ll even show your actors how to use a pipette!

Type 1 Diabetes Funding Opportunities - Breakthrough T1D Explore Breakthrough T1D’s funding opportunities for type 1 diabetes research. Learn how we support innovative projects driving breakthroughs in T1D treatment, prevention, and cures.

Several BreakthroughT1D funding opportunities available

1) Advancing GRS, especially in non-European backgrounds
2) Early detection in adult-onset T1D
3) Tech for scaling manufactured islets

Feel free to reach out with questions. Open to industry and academia

#funding #grants #T1D

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

Are you interested in developing a research programme in cell biology of diabetes? Do you work in pancreatic islets and/or other metabolically relevant cells? We have a Lectureship post opening in our Section @imperialcollegeldn.bsky.social
Apply by 25th March:
www.imperial.ac.uk/jobs/search-...

Listening to my academic friends tell me all about their plans to write and be productive during their sabbaticals knowing full well that if I was ever given one I’d used it to binge watch all 47 seasons of survivor chronologically

Cool advancements! The biggest obstacle for use is still how long it takes to image these things, even using an Operetta it would take me more than a full day to image 96 well plates before with how many stacks were needed for sufficient resolution.

Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages Identification of an LGR5 as a marker for a tripotent stem/progenitor cell of the human fetal pancreas. Organoids derived from single LGR5+ cells are capable of long-term expansion in vitro and genera...

How cool, the Clevers lab able to generate fetal pancreatic organoids with all 3 lineages including insulin+ endocrine cells. Will be a really powerful tool for understanding and modeling pancreatic development and dysfunction.

Effect of Tirzepatide on Body Weight and Diabetes Control in Adults With Type 1 Diabetes and Overweight or Obesity To determine the effect of tirzepatide on weight, diabetes control, and insulin requirements, and its safety profile in adults with type 1 diabetes (T…

Really encouraging results! T1D patients on tirzepatide lost an average of 10% of their bw without an increase in DKA or severe hypoglycemic events … looking forward to future studies with readouts on its effect on CVD

www.sciencedirect.com/science/arti...

Really interesting read! To me, vascularization of grafts is the least developed aspect of islet transplantation and studies like this are helpful for understanding what exactly is it we're trying to build

Stem cell-derived islets engineered to express EGFRt were targeted by CAR-Treg cells to suppress innate and adaptive immune responses, which may prevent immune rejection for #T1D cell therapy. Congrats to the Ferreira and Russ teams! www.cell.com/cell-reports... #regenerativemedicine

Really interesting ... maybe it will help with the shaming (often from medical professionals) of women who struggle to produce enough if there is an additional alternative to formula

Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.

Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social

Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery Pan et al. generate lineage-specific venous endothelial cells with a heterozygous TIE2-mutation from human iPSCs to recapitulate venous malformations in vitro and in vivo. Deep learning combined with ...

Check out this fantastic work by our lab alumnus Kai Wang: Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery. Now out in Cell Stem Cell

www.cell.com/cell-stem-ce...

Diabetes and kidney disease: progress in 2024 - Kidney Research UK From research to workshops with the diabetes community, progress is being made to prevent the progress of diabetes to kidney disease

Great to see this update by Kidney Research UK on all things #Diabetic #Kidneydisease in 2024. Special thanks for highlighting the work of our #PhD student Paige on targetting cell senescence in diabetic nephropathy 👩‍🔬🥼🧪..Full details 👇👇 #NephSky #diabetes

www.kidneyresearchuk.org/2024/10/24/d...

Wow not sure if it was just the gays behind us yas-ing every 15 seconds but the Wicked movie was kind of … incredible?

Also no one sang along!!! I’m sorry I doubted you Times Square AMC, it just felt like you’d be likely to attract people who wouldn’t be able to contain themselves

Actually maybe the sign of mainstreaming is when Greys Anatomy does a CAR T centric episode

Cell therapy manufacturing hubs like the one being built on Long Island are going to be huge for access (and economically) as CAR-T and other treatments expand beyond oncology and become more mainstream, especially as the hypoimmune CAR-T efforts seem to be struggling

Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors

Our new work!

We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).

Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...

Funding Opportunities - Breakthrough T1D Grant handbook A comprehensive collection of Breakthrough T1D’s grant mechanisms and descriptions; application guidelines and checklists; administrative resources; terms and conditions (updated July 2...

⭐💸 Funding Opps 💸⭐

Two new calls from BreakthroughT1D

The first is for advancing technologies that support engraftment of transplants

The second looks at common mechanisms for autoimmune disease

Feel free to reach out with questions

#funding #t1d #grants

www.breakthrought1d.org/explore-rese...

Glucagon-like Peptide-1 Receptor Agonists: New Evidence of Kidney and Cardiovascular Protection From the FLOW and SELECT Trials 👇👇👨‍🔬🧪🥼 #cardiacsky #nephsky #medsky #cardiovascular #kidneydisease #Type2diabetes #semaglutide

www.ajkd.org/article/S027...

One of my favorite things about these early BlueSky days is getting recommended posts like this and discovering entire fields of science I didn’t even know existed/had a name

I set up a calendar reminder to buy I’m Still Here tickets weeks ago but then was too distracted by talks at AHA and forgot to buy them and now they’re sold out 😭😭😭😭

Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity | NEJM Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor...

Another exciting trial result for GLP-1s (tirzepatide), this time for HFpEF

Add that to the growing list of secondary benefits it could have for T1D patients as an adjuvant to insulin

www.nejm.org/doi/full/10....

Looking forward to reconnecting with the science community (and the nice sections of the film community :p ) on this app

I'm also here at #AHA2024 exploring therapies for the T1D community if anyone has insights they'd like to share!