Check out this brand new fellowship from the Simon’s Foundation in Ecology and Evolution. Incoming grad students this year are eligible to apply. No citizenship restrictions. www.simonsfoundation.org/grant/simons...
Itai Yanai is now putting together with Oded Rechavi and others the Woodstock of Biology 2 & Night Science conference to integrate some of Itai's ideas into a scientific meeting. #theconferencetoendallconferences
More info & registration here: woodstock.img.cas.cz
Aneuploidy is the leading cause of pregnancy loss. In work led by @saracarioscia.bsky.social and @aabiddanda.bsky.social, we reanalyzed genetic testing data from 139,416 IVF embryos to discover variants associated with recombination phenotypes and aneuploidy risk. www.medrxiv.org/content/10.1...
A study found junior scientists in large research groups tend to achieve higher academic success but are more likely to quit academia than those in smaller groups.
Successful big-group researchers published more first-author papers with their mentors, via @nature.com
Quite an essay on the basis of cancer entitled "The End of the Genetic Paradigm of Cancer" @plosbiology.org arguing against the primacy of somatic mutations (traditional model) and cells, invoking gene regulatory networks and tissue
journals.plos.org/plosbiology/...
On Science Friday @scifri.bsky.social today, I had the pleasure of chatting with Ira Flatow @heyira.bsky.social about pi, what AI means for the future of math, and whether Einstein was a good math student. Hope you enjoy it! www.sciencefriday.com/segments/pi-...
Congratulations to the new fellows.
I don't write notes in "presenter mode" when I give talks but many use these and that's ok and can calm you down and keep you accurate. However, this often makes the delivery less natural. I wonder why meetings don't have an option to upload presenter notes to a Teleprompter.
A set of three wall shelf sets, in the form of boxplots
📊Looking to re-decorate your #dataviz office?
You need Boxplot Shelves! |----[ ]--|
Today's episode of the Night Science Podcast! Victor Ambros is a 2024 Nobel Prize winner for discovering microRNAs. He talks with us about curiosity-driven research & how a scientist’s unique perspective leads to discoveries others might miss.
open.spotify.com/episode/7jCM... @vambros.bsky.social
Happy to share a new preprint, to which I provided a minor contribution.
Using genetic data from ~100k human embryos, we found ~1k that were haploid or triploid.
We describe a thorough characterization of these embryos, with many interesting findings 🧵
1/9
www.biorxiv.org/content/10.1...
What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX
New year, new beginnings! 🎉
The Aviram Lab will officially open its doors on March 1st @mskcancercenter.bsky.social!
We’ll study microbial immune systems and their connection to fundamental cellular processes like #RNA transcription and #DNA integrity.
#NewPI #AcademicSky #WomenInSTEM
(1/2)
Schematic describing the approximate Bayesian computation approach for inferring rates of meiotic and mitotic error. For each simulation trial, probabilities of meiotic and mitotic error (θ) are each randomly drawn from a uniform distribution ranging from 0 to 1. These values are used to determine the number of cells that will be aneuploid (represented as dark blue in the schematic) versus normal disomic (light blue) in the final embryo. This number is converted to a proportion and then used as input to the Tessera package. For each combination of error parameters (1,000 chosen) and each of three fixed values for dispersal (0, 0.5, 1), 1,000 embryos are generated and biopsied. For each embryo, 8 mitotic divisions are simulated (producing a total of 256 cells), and one 5-cell biopsy is obtained. Using the adaptive method described by Lenormand et al., ABC selects the set of simulations that produce summary statistics (proportions of euploid, mosaic, and aneuploid biopsies) that best reflect the observed biopsy data. The error rates that produced the selected simulations are used to approximate the posterior distributions of these parameters.
Aneuploidy is the leading cause of pregnancy loss. In our latest study (www.biorxiv.org/content/10.1...) led by undergrad Angela Yang, we used a simulation framework to infer rates of both meiotic (39-43%) and mitotic errors (1-3% per division) that best explain data from human IVF embryo biopsies.
Biology of Genomes 2025 is coming up:
- meeting dates: May 6 - 10, 2025
- abstract deadline: Feb 14, 2025
We hope to see you there for another great meeting with a fantastic speaker lineup!
meetings.cshl.edu/meetings.asp...
With Genuity/GMI in Ireland in the rear view mirror, this story current and 23&Me looming, we have to start talking about legislative solutions. When companies go out of business, what should happen with your private data?
www.bbc.com/news/article...
Academia never tells its people 'do something creative and take a risk'. Instead they say:
1. To students: don't be too ambitious
2. To postdocs: work on projects with a high feasibility
3. To assistant professors: play it safe, get tenure
4. To professors: don't lose funding, go with the paradigm.
who knew it would be easier to get everyone to switch social media platforms than getting them to use hg38
Tonight's reading is from Jon Kleinberg and Manish Raghavan.
Elegant mathematical modeling to look at what happens when two decision-makers use the same more accurate algorithm instead of different less-accurate ones.
tl;dr — surprisingly, almost paradoxically, bad things.
In all instances, Israel acted in self-defense against terrorist organizations like Hezbollah and Fatah, which launched attacks from Lebanon. These operations were responses to threats aimed at Israeli civilians. Israel's goal has always been to neutralize these groups, not harm Lebanon itself.
Any military action is aimed at defending civilians from terrorist groups that have repeatedly attacked Israel. The true tragedy is that terrorist organizations like Hezbollah operate within civilian areas, putting innocent lives at risk.
#PeaceForAll #EndTerrorism #DefendInnocents
This accusation is factually false. Israel has not conducted carpet bombing in Beirut or anywhere in Lebanon. Such serious claims should always be backed by credible evidence rather than misinformation. Let’s focus on the truth and avoid spreading unfounded allegations.
#FactCheck #Misinformation
Hello world! 😊
