Football season may be over, but research never stops.
Amid more player deaths, geneticists are asking how else Chronic Traumatic Encephalopathy can be understood and prevented
Learn about the relationship between #CTE, Alz, genetics, and how the NFL is responding
www.penn-ngc.org/beyond-concu...
PNGC says Go Birds!
Genome sequencing results are used to train PRS models but have computation limitations. New portal uses #GWAS summaries and pseudo-training methods to make models more accessible
www.penn-ngc.org/pennprs-a-...
This study from UMASS explores tufts university explores how HSV – 1 might be linked to genetic risk factors for Dementia
#dementia #genesky
This study from UMASS explores tufts university explores how HSV – 1 might be linked to genetic risk factors for Dementia
#dementia #genesky
Investigators from Mass Gen Brigham have conducted a multi-ancestry, whole genome sequencing association study of Alzheimer’s disease and found evidence for 16 NEW susceptibility genes in underrepresented groups
#genesky
Study by Dr. Plotkin identifies distinct microglial protein signatures in cerebrospinal fluid across different stages of Alzheimer's disease, offering potential biomarkers for early-stage detection and highlighting the dynamic role of microglia
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
It is with mixed emotions that we announce the departure of Dr. Kaylyn Clark from our lab.
Dr. Clark has been an integral part of our lab, contributing immensely to our research in her journey from graduate student to postdoc. Her dedication, knowledge, and positive energy will be sorely missed.
(5/5) In October, a preprint was released reintroducing NIAGADS, the National Institute on Aging’s data repository for Alzheimer's Disease research, hosting extensive genetic data and supporting global collaborations to advance research and treatment
www.medrxiv.org/content/10.1...
(4/5) Dr. Kaylyn Clark graduated with a degree in Genomics and Computational Biology from @upenngcb.bsky.social
(3/5) Back in July, our own Dr. Lee , presented his plenary session, "Neuropathology in a Multidisciplinary Age” #AAIC24
(2/5) PNGC researchers presented a bioinformatics strategy for joint-calling 20,504 whole-exome sequencing samples across multiple studies and sequencing centers, successfully accounting for batch effects and generating high-quality variant data
www.nature.com/articles/s41...
(1/5) 2024 was a big year for us! Our scientists produced several preprints, published papers, and attended more than a few conferences
Scroll for some highlights
#genesky #geneticresearch
Find out why Bayesian Tissue Scores are over 100x more efficient in estimating functional annotation effects and context-specific variant fine-mapping compared to existing methods.
See our new preprint
www.biorxiv.org/content/10.1...
#genesky #research
In a recent interview, Pei-Chuan Ho (@pngc.bsky.social/ @pennpathlabmed.bsky.social/ @pennldi.bsky.social) discusses @acadstudy & efforts underway to increase the participation of Asians & Asian Americans in Alzheimer’s Disease research tinyurl.com/4xktvsr4
