So great to see you all and congrats again Benoit on a fantastic keynote!

This thread makes an important point! When talking to Representatives or the media, focus on the health and economic impact. Republican members are usually terrified of China winning — this hands them biomedical supremacy on a platter.

I mis-added earlier, here's corrected post: How many scientists and interior workers were fired today? Between news article estimates and social posts, I count over 10k:

5200 @ NIH
1200-2000 @ DOE
800 @ USDA
2,300 @ Dept. of Interior
1,300 @ CDC
(I haven't heard any FDA, EPA, or NASA numbers)

I feel like this was an unnecessary test to see if I were writing my grant! hahaha. also, if this were old times, you and I would have immediately gone to GNF to get a coffee.....

wait jorg, check now!

unreal

so.... this happening for you all?

Massively parallel characterization of transcriptional regulatory elements - Nature Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements.

Super excited to announce our latest work. On a personal note, it's not an exaggeration to say that blood, sweat, and tears got us to the finish line on this: working w/ an outstanding global team of scientists in Germany, Japan, Russia, and USA responding in >100 pages of complex reviewer comments.

A modified version of the "Pepe Silvia" meme from It's Always Sunny in Philadelphia. A frantic man points at a chaotic evidence board covered with a sketch of a mouse embryo, enhancers, and a gene, connected with tangled lines. He looks intense, as if he's trying to explain a complex, interconnected system. He says "Listen, listen. You don't understand! Those enhancers are everywhere! It's all connected!"

How do 250k regulatory sequences coordinate 15k genes in mammalian development?

Just out: A genomic evidence board to decode the chaos by mapping enhancer-gene interactions across embryonic mouse tissues

New resource with Miao Yu, Ming Hu, Bing Ren, and more.

www.nature.com/articles/s41...

December 10 is the big day for @nobelprize.bsky.social ceremonies—the medals are awarded, and the fabulous banquet takes center stage. Regretting not making it this year, but fondly reminiscing about the 2021 events.

Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart Congenital heart defects (CHD) arise in part due to inherited genetic variants that alter genes and noncoding regulatory elements in the human genome. These variants are thought to act during fetal de...

New work on congenital heart disease genetics from @jengreitz.bsky.social & co

-regulatory mapping from developmental ❤️ tissues

-implication of valvular interstitial cells & epicardial fibroblasts in CHD pathogenesis

Hugely integrative & comprehensive analysis!

www.medrxiv.org/content/10.1...