Thank you @braininspired.bsky.social for a thoughtful journey through neural manifolds, cell types, and brain dynamics. Bridging scales from genes to population activity is where the real story unfolds.
@thetransmitter.bsky.social
#Neuroscience

Post-doctoral Researcher - Sensory and Behavioural Neuroscience Unit Post-doctoral positions are available in the Sensory and Behavioural Neuroscience Unit (https://www.oist.jp/research/research-units/sbn) at Okinawa Institute of Science and Technology Graduate Univers...

We are recruiting a post-doc to study olfactory processing and decision-making in rodents, combining quantitative behavior with neurophysiology.

www.oist.jp/careers/post...

Please share with interested colleagues and trainees 🙏

Transfer to a naturalistic setting restructures fear responses in laboratory mice Zipple et al. show that transferring laboratory mice to naturalistic outdoor enclosures prevents and even reverses a canonical anxiety phenotype in rodents. The findings underscore the value of studyi...

www.cell.com/current-biol...

Expansion microscopy image of perineuronal nets (unpublished).

1/ 97% of cortical PNNs are on PV interneurons. But PNN-positive and PNN-negative PV cells don't split into two groups — they sit at different ends of a transcriptional continuum of fast-spiking specialization. New preprint 🧵

The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states!

Out today in Nature: rdcu.be/fdC2A

@uclbrainscience.bsky.social

Ultra-wide-field, deep, adaptive two-photon microscopy for multi-scale neuronal imaging Light: Science & Applications - ULTRA, an ultra-large-FOV two-photon microscope enabling cellular-resolution imaging across 50 mm² and 900 μm depth, facilitating comprehensive,...

Want to image the activities of many thousands of neurons over an 8mm diameter field of view, in behaving mice? Read our new paper, just published in Light: Science & Applications.

Yang et al, Ultra-wide-field, deep, adaptive two-photon microscopy for multi-scale neuronal imaging. rdcu.be/fc57b

Wanna do neuroscience in Paris but can't find interesting lab?

Want to come do a sabbatical but don't know who to collaborate?

Check this webpage aggregating ~all the neuroscience labs (+200) in Paris.

⚠️only the information of 'verified' profiles is reliable⚠️

Please retweet 🙏

parisneuro.fr

New paper out 🎉

Awake fUSI is powerful, but motion can strongly bias the data, even in head-fixed experiments.

In this paper, we tried to systematically characterize those artifacts, benchmark denoising strategies, and turn that into practical recommendations for awake fUSI of mouse brains.

1/12

a house mouse interacting with a problem-solving setup in a seminatural enclosure

Are innovators born that way, or does solving problems come from experience?🐭

In our recent(ish) paper in @asab.org with @valmazza.bsky.social & Anja Guenther, we show innovation may be inherent in wild house mice and experience makes innovators better!

paper: doi.org/10.1016/j.anbehav.2025.123441

If you are interested in systems neuroscience, learning about data analysis, or understanding how the conceptualization of analyses can influence results, join us for the Brainhack satellite event at #FENS2026!

More info at: pre-fens-brainhack.github.io/brainhack2026/

Dorsoventral hippocampus neural assemblies reactivate during sleep following an aversive experience - Nature Neuroscience Synchronization of sharp-wave ripples across the dorsoventral hippocampus during sleep supports coordinated reactivation that represents negative experiences more faithfully than positive ones.

Our paper is out today!!! (not an April fool's day joke) Congrats to authors @azulsilva.bsky.social, @belalima-paiva.bsky.social, Ele Pronier, and mostly to the amazing scientist and human being who led this project @facuumm.bsky.social
#neuroskyence #hippocampus
www.nature.com/articles/s41...

The new Cajal Center is opening 8 CSIC permanent research positions (CT, IC & PF levels) via national competitive exams. We welcome candidates eager to shape an ambitious 🧠 research hub in Spain.
🔗 sede.csic.gob.es/tramites/con... 📣
#Neuroscience #CNC #CSIC #ScienceJobs 👇🏼

📣 PhD position in computational & systems neuroscience (Marseille, France).

⏰ Deadline 28 Jan.

We are recruiting a PhD student to work on neuromodulatory control of predictive processing in mouse vision, jointly supervised by @ederancz.bsky.social (INMED) and @laurentperrinet.bsky.social (INT).

Dendrite-targeting OLM interneurons regulate the formation of learning-related CA1 place cell representations Spatial learning depends on the rapid formation of hippocampal CA1 place cell representations through behavioral timescale synaptic plasticity (BTSP)[1][1]–[7][2]. BTSP is driven by dendritic Ca²⁺ pla...

www.biorxiv.org/content/10.6...

Deadline is approaching too fast!! Don’t miss it!

Fully funded PhD position between our lab in Göttingen and @tobiasackels.bsky.social in Bonn! Dual-color imaging 🔬🐁 in freely moving mice, behavioral analysis, olfactory 👃 and spatial coding in #hippocampus... It's a cool project in two fantastic labs. Reach out if interested! 🤙 #neuroskyence

Adaptive communication between cell assemblies and “reader” neurons shapes flexible brain dynamics Cell assemblies have been proposed as key units of brain activity, underlying diverse functions, but their basic features are not well understood. This study shows that interactions between cell assem...

Cell assemblies are drawing increasing attention in neuroscience, but one could argue that they are just an epiphenomenon. Is the activity of cell assemblies relevant for the brain?
The short answer is yes. The long answer is in our paper, now online at PLOS Biology. 🧵👇 1/10
doi.org/10.1371/jour...

Great opportunity for junior/mid career neuroscientists in Europe! Do apply!

Excited to share our new preprint! We use advanced models to show how PV+ interneurons can toggle hippocampal rhythms, switching between memory encoding & recall states simply by activating different nonlinear dendritic branches. 🧠⚡️ www.biorxiv.org/content/10.1...

Wow!

A novel, evolutionarily conserved inhibitory circuit selectively regulates dentate gyrus mossy cell function

www.biorxiv.org/content/10.1...

Vargish,Rice,Yuan,Hunt,Hines,Plotnikova,Mohanty,Furlanis, Wang,Dai,Garcia,Cummins,Eldridge,Averbeck,Zaghloul, Dimidschstein,Fishell,Pelkey,McBain

Systems and circuit neuroscience need an evolutionary perspective To identify fundamental neuroscientific principles that generalize across species, neuroscientists must frame their research through an evolutionary lens.

To identify fundamental neuroscientific principles that generalize across species, systems and circuits, neuroscientists must embrace an evolutionary perspective, argue Karl Farrow and @katjareinhard.bsky.social.

#neuroskyence

www.thetransmitter.org/systems-neur...

We are hiring! — Semantic memory Lab

We are hiring! 2 PhD position available on semi-naturalistic behavioral phenotyping and housing projects to increase translation. www.genzellab.com/we-are-hiring

GitHub - Julie-Fabre/bombcell: Automated quality control, curation and neuron classification of spike-sorted electrophysiology data Automated quality control, curation and neuron classification of spike-sorted electrophysiology data - Julie-Fabre/bombcell

🚀 We are excited to share that bombcell is now available in Python! 🐍 Automatically sort your units into good/MUA/noise/non-somatic using quality metrics and interpretable & adjustable classification thresholds.
pip install and play around with our toy dataset:
🔗 github.com/Julie-Fabre/...

Neuroscience methods - YouTube Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...

Announcing two new lectures in our youtube neuroscience methods course:

Lecture 12: experimental design (by Anita Autry)
Lecture 13: neuronal population coding (in which I advocate a viewpoint that is... controversial)

Please repost to help us spread the word!

www.youtube.com/playlist?lis...

I'm pleased to share our new work, “Spatio-temporal organization of network activity patterns in the hippocampus”, out in @cp-cellreports.bsky.social !
With Demi Brizee & David Dupret, we track how oscillations and spiking behaviour map onto hippocampal layers using an LFP-based embedding.

(1/13)

One week left to apply for a poster presentation at the 1st Paris Circuit Dynamics Conference on "Hippocampal–Cortical Circuits", on 28 - 29 April 2025 at the Paris Brain Institute.

www.paris-circuits.eu

Vibrational fiber photometry: label-free and reporter-free minimally invasive Raman spectroscopy deep in the mouse brain - Nature Methods Vibrational fiber photometry enables Raman spectroscopy in the mouse brain with low impact, owing to the use of tapered fibers.

Exciting news from the lab! In collaboration with our #EU-Nanobrigth partners, we’ve developed and tested a new probe for vibrational fiber photometry, enabling minimally invasive Raman spectroscopy deep into the 🧠. www.nature.com/articles/s41... @naturemethods.bsky.social

Pls reskeet! Just five more days to apply for this cool (admittedly, I'm biased) and fully-funded #PhD project in our lab!